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EC number: 218-159-1 | CAS number: 2057-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Non-irritating in in vivo testing
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: US OSHA: 16 CFR 1500.41
- Principles of method if other than guideline:
- Protocol according to U.S. FHSA: occlusive exposure of intact and abraded skin for 4 hours.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals for this test were subjected to no other experimentation prior to the study. Animals selected were obtained from a larger pool of other animals and were examined to ensure that their skin was free from irritation, trauma, and disease.
They were sourced from Eastern Rabbit Breeding Laboratories, Taunton, MA, USA. They weighed 2-3 kg at the start of the study and were 10-12 weeks of age.
Animals were housed individually using suspended stainless steel cages. Hardwood chips were used for non-contact bedding under the cages.
Animal rooms were maintained at 68±3 deg. F, with Humidity maintained at 30-70%. A 12 hour light/dark cycle was used
All animals were supplied with a commerical rabbit ration and municiple tap water ad libitum.
Upon receipt, all animals were housed in quarantine for a period of 4 days under the same conditions as the actual test. - Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- The test material applied was introduced under a guaze pad two layers thick, measuring 2.5cm x 2.5cm, which were held together by an impervious (occlusive) bandage.
- Duration of treatment / exposure:
- Skin was exposed to the test material for a 4 hour period
- Observation period:
- After test material was removed, the test sites were monitered for signs of irritation at 24 and 72 hours.
- Number of animals:
- 3 males and 3 females.
- Details on study design:
- Test and control sites of each rabbit were clipped of all hair around the trunk.
One application site of each animal was abraded by making minor incisions through the stratum corneum, but not sufficient enough to disturb the derma.The second application site was intact skin.
The animals were treated by introducing the test substance to the skin using a gauze pad 2.5 cm x 2.5 cm, and was held together by an impervious bandage.
The test material was held to the skin for a period of four hours before it was removed and cleaned of any excess material.
Each animal served as its own control (untreated site).
At the end of the study (72 h after application), the animals were weighed and euthanised with a barbiturate (Euthanasia-5, Verterinary Labortories Inc., Topeka, KS). - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was found to be non-irritating to the skin of New Zealand Rabbits after occlusive exposure of intact and abraded skin to 4-phenylpropylpyridine for 4 hours.
Reference
None of the test sites of any animal at any time during the study showed signs of erythema or edema, whether the skin was abraded or intact.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: 29 CFR 1910-1200 and 16 CFR 1500.41
- Principles of method if other than guideline:
- The test was conducted based on US OSHA, 29 CFR, 1910.1200 and 16 CFR 1500.41
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Six healthy, young adult, 3 male and 3 female rabbits were used in the study.
Animals were purchased from a registered commercial breeding laboratory (Eastern Rabbit Breeding Laboratory, Taunton, MA)
Animals weighed between 2.0-3.0 kg
Animals were individually housed in seperate suspended cages.
Rooms were maintained at 68 degrees F.
12 hour dark/light periods were provided.
Animals were supplied with commercial rabbit ration and tap water ad libitum. - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- A dose of 0.1 mL was administered to each animal
- Duration of treatment / exposure:
- Animals were checked for signs of irritation 24 hours after the substance was applied to the eye, and the eye was rinsed of any leftover test material.
- Observation period (in vivo):
- Observation occured 24 hours after application of substance
- Duration of post- treatment incubation (in vitro):
- After observation at 24 hours, the eyes were checked again at 48 and 72 hours.
- Number of animals or in vitro replicates:
- 6 total animals were used in the study
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 6
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was tested in an eye irritation assay in rabbits and found to be non-irritating.
Reference
One of the six rabbits was shown to have a positive conjunctival erythema result. The test substance is considered non-irritating to the eyes.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Testing with rabbits using standard protocols for skin irritation and skin corrosion resulted in findings that 4-PPP is not an irritant. It was also found not be an eye irritant in rabbits. This contrasts with observations from the irritation screening of the dermal sensitisation study in guinea pigs that undiluted 4-PPP resulted in mild skin irritation. The irritation testing results in a standard species carry greater weight; hence the substance is evaluated as non-irritating to the skin and eye.
Justification for classification or non-classification
The substance is not irritating to the eye or skin. It does not meet the criteria for classification according to Regulation EC No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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