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EC number: 218-076-0 | CAS number: 2049-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Acute toxicity by oral route: the oral LD50 value of tertiary-amylbenzene in Wistar rats was established to exceed 2000 mg/kg body weight.
- Acute toxicity by inhalation route: no data available.
- Acute toxicity by dermal route: no data available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 December 2009 - 20 January 2010 (in-life phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent GLP and guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Young adult animals (approx. 9 weeks old) were selected. Body weight variation did not exceed +/- 20% of the sex mean.
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Method: Oral gavage, using plastic feeding tubes.
- Fasting: Animals were deprived of food overnight prior to dosing and until 3-4 hours after administration of the test substance. Water was available.
- Frequency: Single dosage, on Day 1. - Doses:
- 2000 mg/kg (2.051 mL/kg) body weight.
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- Tertiary-amylbenzene was administered by oral gavage to two subsequent groups of three female Wistar rats at 2000 mg/kg body weight. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice (Day 15).
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: On Day 1, uncoordinated movements, piloerection and/or salivation was seen among the animals. Rales and tremors were displayed by one animal. Hunched posture was noted in all animals on Days 1 and 2.
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions of this study, the oral LD50 value of tertiary-amylbenzene in Wistar rats was established to exceed 2000 mg/kg body weight. Therefore, no classification is required according to EU criteria.
- Executive summary:
The acute oral toxicity of tertiary-amylbenzene for rats was determined according to the Acute Toxic Class Method.
The study was carried out based on the guidelines described in:
- OECD No.423 (2001) "Acute Oral Toxicity, Acute Toxic Class Method"
- Commission Regulation (EC) No 440/2008, B1 tris: "Acute Oral Toxicity, Acute Toxic Class Method"
- EPA, OPPTS 870.1100 (2002), "Acute Oral Toxicity"
- JMAFF guidelines (2000) including the most recent partial revisions.
Tertiary-amylbenzene was administered by oral gavage to two subsequent groups of three female Wistar rats at 2000 mg/kg body weight. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice (Day 15).
No mortality occurred. On Day 1, uncoordinated movements, piloerection and/or salivation was seen among the animals. Rales and tremors were displayed by one animal. Hunched posture was noted in all animals on Days 1 and 2. The body weight gain shown by the animals over the study period was considered to be normal. No abnormalities were found at macroscopic post mortem examination of the animals.
The oral LD50 value of Tertiary-amylbenzene in Wistar rats was established to exceed 2000 mg/kg body weight. According to the OECD 423 test guideline and considering the clinical signs noted, the LD50 cut-off value was considered to be 5000 mg/kg body weight. Based on these results, no classification is required according to EU criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Guideline and GLP study.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral route:
One study was available and selected as the key study (OECD No.423, GLP and Reliability.1). Tertiary-amylbenzene was administered by oral gavage to two subsequent groups of three female Wistar rats at 2000 mg/kg . No mortality occurred. On Day 1, uncoordinated movements, piloerection and/or salivation was seen among the animals. Rales and tremors were displayed by one animal. Hunched posture was noted in all animals on Days 1 and 2. The body weight gain shown by the animals over the study period was considered to be normal. No abnormalities were found at macroscopic post mortem examination of the animals. The oral LD50 value of Tertiary-amylbenzene in Wistar rats was established to exceed 2000 mg/kg body weight. According to the OECD 423 test guideline and considering the clinical signs noted, the LD50 cut-off value was considered to be 5000 mg/kg body weight.
Inhalation route:
No data is available for this route of administration.
Dermal route:
No data is available for this route of administration.
Justification for classification or non-classification
Harmonized classification:
Not classified.
Self-classification:
As the LD50/rat by oral route is > 2000 mg/kg bw, Tertiary-amylbenzene is not classified according to EU criteria.
By inhalation and dermal routes, no classification is proposed due to lack of data.
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