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EC number: 216-706-9 | CAS number: 1646-26-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 February to 3 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health, Bern, Switzerland
- Type of method:
- flask method
- Key result
- Water solubility:
- 453 mg/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- ca. 7.1
- Conclusions:
- A water solubility value of 453 ± 6 mg/L (at 20 °C, pH ca. 7.1) was determined for the test substance according to OECD 105.
Reference
The R² fit of the calibration curve used was 0.9993. This reflects the linearity of the analytical system within the calibration range of 30.0 to 120 mg test item /L. The calibration was verified by a 2nd weighing of the test item and dilution of this stock solution into the calibration curve at levels of 41.7, 62.5 and 104 mg/L. Analysis of these quality control solutions and evaluation against the calibration curve yielded recoveries of 104%, 102% and 102% compared to the nominal values. These data show the correct preparation of the calibration standards.
The following table summarizes the results of the water solubility test. The tabulated values represent rounded results, obtained by calculation using the exact raw data.
Sample No. |
Shaking time at 30 °C |
Determined concentration |
Water Solubility Mean Value |
Overall Mean ± Std. Dev. |
Rel. Std. Dev. |
|
[hours] |
[mg/L] |
[mg/L] |
[mg/L] |
[%] |
72-7 |
72 |
440 |
447 |
453 ± 6 |
1 |
72-8 |
72 |
453 |
|||
48-7 |
48 |
452 |
453 |
||
48-8 |
48 |
454 |
|||
24-7 |
24 |
459 |
460 |
||
24-8 |
24 |
460 |
According to the test guideline, the results for three assays should not differ by more than 15% for three assays. The acceptance criterium was fulfilled. Thus, the study is valid.
The test item showed to be stable during the performance of the test.
A mean pH value of 7.1 was measured for the used solutions.
The water solubility of the test substance was found to be 453 ± 6 mg/L.
Description of key information
Water solubility: 453 ± 6 mg/L at 20 °C, pH ca. 7.1 (OECD Guideline 106, flask method)
Key value for chemical safety assessment
- Water solubility:
- 453 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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