Methoxyacetic acid

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

06.11 - 10.11.1989

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Version / remarks:

adopted April 1984

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method C.1 (Acute Toxicity for Fish)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Methoxyacetic acid

EC Number:

210-894-6

EC Name:

Methoxyacetic acid

Cas Number:

625-45-6

Molecular formula:

C3H6O3

IUPAC Name:

2-methoxyacetic acid

Constituent 2

Reference substance name:

2-methoxyacetic acid

IUPAC Name:

2-methoxyacetic acid

Details on test material:

- Name of test material (as cited in study report): Methoxyessigsäure
- Physical state: liquid, colourless
- Storage condition of test material: stored at 4 °C in the refrigerator, in closed container
- Density: ca. 1.18 g/mL

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96

Remarks on exposure duration:

h

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 500 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Any other information on results incl. tables

Sublethal observations / clinical signs:

Analytical dose verification was 106.9 %. Water quality parameter like temperature, dissolved oxygen and pH were within acceptable limits. Sublethal effects like gills stuck in a gapping position or swimming behaviour was observed in the 500 g/mL group.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Based on the results of this study the 96-hour LC50 of Brachydanio rerio was determined to be higher than 500 mg/L.

Executive summary:

In a 96-h acute toxicity study, Brachydanio rerio were exposed to Methoxyacetic acid at nominal concentrations of 0 (control) and 500 mg a.i./L under static conditions. The 96-h LC50 was higher 500 mg/L, the highest concentration tested. Sublethal effects like uncoordinated swimming were observed in the group exposed to Methoxyacetic acid.