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EC number: 208-291-8 | CAS number: 520-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 23rd to May 25th, 2016.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.19 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- >= 5.98 - <= 6.02
- Details on results:
- Solubility of the test item in distilled water is 0.019 ± 0.005 mg/L at pH = 6.04 - 6.08.
- Conclusions:
- The solubility of the test item at 20 ± 0.5 ºC and at pH ranging 5.98 - 6.02 in water is 0.19 ± 0.004 mg/L.
- Executive summary:
The study of the water solubility of the test item was performed by the column elution method, according to OECD 105 / EU Method A.6 (GLP study). The test item was dissolved in acetone and added to innert support material. Then, the solvent was evaporated, and the loaded support material was soaked for 2h in 5 ml of water. This suspension was added to a micro-column and the test item was eluted until the concentration reached a plateau. The mass concentration of the eluate at this time was determined by UVVIS spectrophotometry, and taken as the water solubility value. Based on the test results, the solubility of the test item in water of the test item at 20 ± 0.5 ºC and at pH ranging 5.98 - 6.02 in water was found to be 0.19 ± 0.004 mg/L.
Reference
Table 1. Results of the preliminary test
0.01 g in x mL of water |
0.05 |
0.1 |
0.2 |
1 |
10 |
100 |
200 |
1000 |
>1000 |
Soluble (+/-) |
- |
- |
- |
- |
- |
- |
- |
- |
+ |
Approximate solubility, |
> 200 |
200 |
100 |
50 |
10 |
1 |
0.1 |
0.05 |
< 0.01 |
The final approximate solubility was found to be < 0.01 g/L.
Table 2. Study solution – first run.
Sample |
Sample volume |
Absorbance Ap |
X [mg/L] |
1 |
15 |
0.259 |
0.228 |
2 |
15 |
0.26 |
0.229 |
3 |
15 |
0.254 |
0.224 |
4 |
15 |
0.253 |
0.223 |
5 |
15 |
0.247 |
0.218 |
6 | 15 | 0.246 | 0.217 |
Table 3. Study solution – second run.
Sample |
Sample volume |
Absorbance Ap |
[mg/L] X |
1 |
15 |
0.191 |
0.168 |
2 |
15 |
0.191 |
0.168 |
3 |
15 |
0.187 |
0.164 |
4 |
15 |
0.187 |
0.164 |
5 |
15 |
0.183 |
0.161 |
6 | 15 | 0.188 | 0.165 |
Table
4. Results of Diosmetin solubility at 20 ± 0.5 ºC in
distilled water, column elution with recirculating pump method.
|
1 |
2 |
3 |
4 |
5 |
6 |
Average |
Average |
|
1 |
Concentration |
0.23 |
0.23 |
0.22 |
0.22 |
0.22 |
0.22 |
0.22 ± 0.01 |
0.19 ± 0.04 |
pH |
6.01 |
6.00 |
6.00 |
6.02 |
6.01 |
6.00 |
|||
2 |
Concentration |
0.17 |
0.17 |
0.16 |
0.16 |
0.16 |
0.17 |
0.17 ± 0.003 |
|
pH |
5.99 |
5.98 |
6.00 |
5.98 |
6.01 |
5.99 |
Description of key information
Key study. Method according to OECD 105 / EU Method A.6 (column elution method), GLP study. The solubility of the test item in water of the test item at 20 ± 0.5 ºC and at pH ranging 5.98 - 6.02 in water was found to be 0.19 ± 0.004 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.019 mg/L
- at the temperature of:
- 20 °C
Additional information
The study of the water solubility of the test item was performed by the column elution method, according to OECD 105 / EU Method A.6 (GLP study). The test item was dissolved in acetone and added to innert support material. Then, the solvent was evaporated, and the loaded support material was soaked for 2h in 5 ml of water. This suspension was added to a micro-column and the test item was eluted until the concentration reached a plateau. The mass concentration of the eluate at this time was determined by UV-VIS spectrophotometry, and taken as the water solubility value. Based on the test results, the solubility of the test item in water of the test item at 20 ± 0.5 ºC and at pH ranging 5.98 - 6.02 in water was found to be 0.19 ± 0.004 mg/L.
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