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Diss Factsheets
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EC number: 207-050-4 | CAS number: 428-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The short-term toxicity to fish was estimated using two separate approaches. An estimated LC50 (96 h) for freshwater fish (9.06 mg/L) was taken into account for acute fish toxicity for the derivation of the PNEC.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 9.06 mg/L
Additional information
Given the experimental difficulties of testing a gas, non-testing approaches were exploited to address the information requirements for this endpoint. The short-term toxicity to fish was estimated using two separate approaches, the US EPA’s ECOSAR model as well as the OECD Toolbox. A prediction of the 96 hr LC50 to fish was undertaken by ECOSAR. The test substance was found to trigger the Epoxides Mono SAR within ECOSAR. The expectation thus was that the test substance would exert a greater toxicity on account of its electrophilicity than that predicted by LogKow alone using the baseline narcosis equation (termed the neutral organics SAR within ECOSAR). The test substance was additionally profiled within the OECD Toolbox to verify its presumed mode of action. The OASIS Mode of Action and the Verhaar scheme assigned the test substance as “Reactive unspecific” and “Class 3 unspecific reactivity” respectively i.e. an excess toxicity relative to the baseline would be anticipated for the test substance. Using the estimated LogKow and measured water solubility, a LC50 was derived by ECOSAR. Other analogues identified using the OECD Toolbox containing an epoxide functionality and having a similar LogKow value were found to be reasonably predicted by ECOSAR relative to their experimental findings. The estimate was concluded to be reasonable for the purposes of characterising the endpoint.An endpoint specific grouping was also attempting using the OECD Toolbox. The Toolbox is a tool in development under the OECD QSAR workprogramme which aims to develop, justify, evaluate and document chemical categories in accordance with the REACH Technical Guidance for chemical categories. An initial grouping of substances sharing an epoxide group using the ECOSAR chemical classes served as a starting point for developing a category. A subcategorisation on the basis of protein binding alerts was then performed. Short term toxicity data in fish was then extracted and a trendline investigated. Since no significant differences were noted in the actual trendline derived for individual species vs all species, a decision was taken to maximise all the data available in order to derive as robust a correlation as possible. The TPRF provided as an attachment in IU5 describes the domain characteristics in more detail. The test substance fell within the domain described and a LC50 estimate was derived.With both approaches, the estimated 96-hr LC50 for fish was much greater than the measured water solubility for the substance. The estimated LC50 (96 h) for freshwater fish (9.06 mg/L) as determined by the OECD Toolbox was the more conservative value, hence this was used for the purposes of deriving the PNEC.
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