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EC number: 205-286-2 | CAS number: 137-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50(48 h):139 µg/L (mean measured, OECD 201, flow-through, Daphnia magna)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 139 µg/L
Additional information
In the available key study (2015) on short-term toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) towards aquatic invertebrates, neonates of Daphnia magna were exposed for 48 hours under flow-through conditions to five test item concentrations ranging from 11 to 260 µg Thiram technical/L (mean measured). The test was performed according to OECD guideline 202 (GLP). Tetramethylthiuram disulfide (CAS No. 137-26-8) water concentrations were analyzed at 0, 24, and 48 h of exposure. Mean measured concentrations represented 85, 71, 78, 82 and 86 % of nominal concentrations. Therefore, the effect values were based on mean measured concentrations. The EC50 (48 h) value was determined to be 139 µg a.i./L (mean measured). The NOEC (48 h) value based on mobility was determined to be 50 µg a.i./L (mean measured).
Furthermore, two supporting, static guideline (OECD 202, GLP) studies on short-term toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to Daphnia magna are available. The first supporting study (2008) was conducted with the product Thiram 80 WG. After 48 hours of exposure to this product, concentration dependent effects on mobility were observed resulting in a NOEC (48 h) value of 0.14 mg a.i./L (measured initial) and an EC50 (48 h) of 0.38 mg a.i./L (both measured initial). Results from the second supporting study (1994), are less reliable due to low recovery rates already at test initiation (25-93%). The recoveries at study termination were even lower and ranged between n.d. and 43%. The EC50 value can thus not be calculated based on measured data. However, the calculated nominal EC50 (48 h) value was in the same range as those of the key and supporting study mentioned above and therefore these data were considered acceptable as supporting information.
Two further studies on the short-term toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to aquatic invertebrates are available but possess a minor reliability (RL3 and RL4) and were therefore disregarded.
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