Registration Dossier
Registration Dossier
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EC number: 204-016-0 | CAS number: 112-91-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance does not show any activity on bacterial mutagenicity. Also bacterial mutagenicity studies with other alkylnitriles show negative results. Additionally, a mammalian chromosomal aberration study on V97 cells according to OECD 473 has been performed with Dodecanenitrile and also does not indicate any genotoxic potential.
Additionally, the alkylnitriles do not react with DNA or react to protein (indicated by OECD Toolbox profiling).
Short description of key information:
In vitro Bacterial Reverse Mutation Test (Ames): not mutagenic
In vitro Mammalian Chromosomal Aberration Test: not genotoxic
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Alkylnitriles do not interact with DNA or protein. Available bacterial mutagenicity studies and an in vitrochromosomal aberration study show no indication of genotoxic potential.
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