Registration Dossier
Registration Dossier
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EC number: 204-016-0 | CAS number: 112-91-4
Endpoint summary
Administrative data
Description of key information
Acute toxicity: Oral LD50 > 5,000 mg/kg for rat (LD50 limit test - no mortality)
Key value for chemical safety assessment
Additional information
Oleylnitrile was tested for acute oral toxicity at a dose level of 5000 mg/kg to 5 male and 5 female rats.
There were no mortalities observed. Body weight gain was normal during the 14 -day observation period for all groups. Clinical signs were generally observed up to the end of the 14-day period in all animals, and consisted of pilo-erection, urine stains, scruffy hair coat, red-brown stains around the nose, coats oily on the dorsal side, and areas of alopecia on the back or hind legs. Terminal autopsy findings were normal except for the left kidney of one female that appeared slightly hollowed.Justification for classification or non-classification
Only limited to no toxicity was observed after oral dosing of 5000 mg/kg, and hence no classification for acute oral toxicity is indicated.
Based on the very low water solubility and relative high Pow of 5, the rate of transfer to the epidermis is probably limited. However, the molecular size is not large and high Pow favours uptake in the stratum corneum. As worst case, 100% dermal absorption is assumed although in view of anticipated slow uptake into epidermis, systemic peak concentrations will be lower following acute dermal exposures compared to the oral route.
Tallownitrile is further mildly irritating to skin, and not irritating to the eyes, and consequently it is not expected to exert serious systemic toxicity by dermal or inhalation routes even when uptake is to be considered similar as following oral route.
Physical-chemical properties of Oleylnitrile, being a liquid at room temperature with a relatively low vapour pressure (Probably much less than the vapour pressure of 1.8 Pa at 20°C for Coconitrile) and low water solubility (for C16 part in Coco < 0.005 mg/L), would also limit the likelihood of significant exposures by inhalation.
Consequently, Oleylnitrile need not be classified for acute toxicity by dermal or respiratory route.
Alkylnitriles do not contain aliphatic, alicyclic and aromatic hydrocarbons. Also lack of surface activity (based on structure) indicates there is no aspiration hazard for Tallownitrile.
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