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EC number: 203-120-3 | CAS number: 103-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29-03-2005 to 02-05-2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): City of Geneva, Peney-Dessous.
- Storage length: collected in the morning to be used on the same day
- Preparation of inoculum for exposure: washed 3 times with mineral medium, centrifuging at 1000g for 10 minutes, discarding the supernatant and resuspending in mineral medium
- Storage conditions: kept aerobic
- Determination of the dry weight of suspended solids: two 50 mL samples of homogenised sludge are used, the water is evaporated on a steam bath and the sludge is subsequently dried at 105-110°C for 2 hours. The residue is weighed. - Duration of test (contact time):
- 34 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
Solution A: 8.5g KH2PO4, 21.75g K2HPO4, 33.4g Na2HPO4.2H2O and 0.5g NH4Cl dissolved in water and made up to 1 L.
Solution B: 27.5g CaCl2 dissolved in water and made up to 1 L.
Solution C: 22.5g MgSO4.7H2O dissolved in water and made up to 1 L.
Solution D: 0.25 g FeCl3.6H2O and one drop HCl conc. dissolved in water and made up to 1 L.
Medium: 50 mL Solution A + 2000 mL deionised water + 5 mL each of solutions B, C and D, and making up to 5 L. Adjustment of the pH to 7.4 +/- 0.2 with phosphoric acid or potassium hydroxide.
- Test temperature: 22°C
TEST SYSTEM
- Culturing apparatus: In Sapromat bottles
- Number of culture flasks/concentration: 2
- Measuring equipment: Sapromat
SAMPLING
- Sampling frequency: daily
- Sampling method: recording of oxygen consumption as measured by Sapromat device
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 81
- Sampling time:
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 84
- Sampling time:
- 34 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The substance was found mineralize to up to 81% after 28d. Nevertheless, the 10-day window is not met, and hence the substance is concluded to be not readily biodegradable according to OECD criteria.
- Executive summary:
The ready biodegradability of the test item was determined by the Manometric Respirometry test according to OECD Guideline 301F and GLP. The substance was found to reach 81% of biodegradation after 28 days. The 10 - day window was not met: 14% degradation on day 2; 58% degradation on day 12. The toxicity control (biodegradation of test item + reference substance) showed that the test item is not toxic towards the microorganisms at the tested concentration (100 mg/L). As a consequence, the test shows that the substance is not readily biodegradable according to OECD criteria.
Reference
% Degr. |
2 |
7 |
12 |
21 |
28 |
34 |
Flask 1 |
15 |
53 |
65 |
81 |
85 |
86 |
Flask 2 |
13 |
42 |
51 |
67 |
77 |
82 |
Mean |
14 |
47 |
58 |
74 |
81 |
84 |
Degradation with the reference substance sodium benzoate reached >40% after 7 days and > 65% after 14 days. Hence, the activity of the inoculum is verified.
The repeatability validity criterion is fulfilled: not more than 20% difference between replicates.
Description of key information
81% after 28 days (10 -day window was not met) (OECD 301 F)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
Additional information
The ready biodegradability of the test item was determined by the Manometric Respirometry test according to OECD Guideline 301F and GLP. The substance was found to reach 81% of biodegradation after 28 days. The 10 - day window was not met: 14% degradation on day 2; 58% degradation on day 12. The toxicity control (biodegradation of test item + reference substance) showed that the test item is not toxic towards the microorganisms at the tested concentration (100 mg/L). As a consequence, the test shows that the substance is not readily biodegradable according to OECD criteria.
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