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EC number: 202-826-9 | CAS number: 100-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion
The test substance was rated a moderate irritant to guinea pigs.
Eye irritation
Test item is slightly irritating to the eyes of rabbits. Immediate washing was beneficial.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Remarks:
- in vivo study that was performed prior to current requirement for in vitro alternative testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 January 1982 - 16 April 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test was conducted according to an internal method.
- GLP compliance:
- no
- Specific details on test material used for the study:
- TEST MATERIAL
- name as cited in test report: p-diisopropylbenzene
- Molecular weight: 162 g/mol
- Molecular formula: C12H18
- Physical state: liquid
- Boiling point: 208 °C at 760 mmHg
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability with H+; OH-; Heat, Light, H2: given - Species:
- guinea pig
- Strain:
- not specified
- Type of coverage:
- occlusive
- Preparation of test site:
- other: depilated
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- single dose
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 2 weeks
- Details on study design:
- occluded, single exposure, 24 hours
(guinea pig abdomen)
and
open, Repeated (10 doses) - 5 animals - Irritation parameter:
- overall irritation score
- Basis:
- animal:
- Remarks on result:
- other: Moderate erythema, edema and some necrosis.
- Irritation parameter:
- edema score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- The compound was a moderate skin irritant when applied to the depilated guinea pig abdomen under an occlusive wrap for 24 hours. It produced moderate erythema, edema and some necrosis. Thin eschars at one week, light scarring desquamation and alopecia at 2 weeks.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- p-diisopropylbenzene was rated a moderate irritant under the conditions of this study.
- Executive summary:
p-diisopropylbenzene was a moderate skin irritant when applied to the depilated guinea pig abdomen under an occlusive wrap for 24 hours.
It produced moderate erythema, edema and some necrosis. Thin eschars at one week, light scarring desquamation and alopecia at 2 weeks.
Reference
Occluded, single dose:
The compound produced moderate to severe erythema and edema and some necrosis initially; eschars were present after one week, and scarring, desquamation and alopecia were present after two weeks at doses ranging from 20 mL/g down to 1 mL/kg.
Open, Reapead (10 Doses) - 5 animals:
Moderate to severe erythema and edema replaced by thick, broken eschars at day 10.
Skin Absorption possible
Repeated daily application (10) of 0.5 mL of the material moderately exacerbated the initial response. Moderate to severe erythema and edema and petechial hemorrhages were present at day 1. By day 10, the application site in all animals was characterized by thick, broken eschars. Absorption of the compound through the skin was possible, since three of five animals in the repeated skin application test lost weight over the course of the study.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Remarks:
- in vivo study that was performed prior to current requirement for in vitro alternative testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 January 1982 - 16 April 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The eye irritation test was performed onto both eyes of 3 rabbits; in one eye of each rabbit, the material was immediately rinsed with water, while in the other eye, the material remained without washing.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- TEST MATERIAL
- name as cited in test report: p-diisopropylbenzene
- Molecular weight: 162 g/mol
- Molecular formula: C12H18
- Physical state: liquid
- Boiling point: 208 °C at 760 mmHg
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability with H+; OH-; Heat, Light, H2: given - Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Number of animals or in vitro replicates:
- 3animals
3 eyes washed, 3 eyes unwashed - Irritation parameter:
- overall irritation score
- Basis:
- animal: 1, 2, 3
- Time point:
- other: 1h
- Remarks on result:
- other: 3 of 3 animals with washing after treatment and 3 of 3 animals without washing after treatment showed slight irritation, limited to erythema of adnexa, resolved after one hour
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- other: None of the three animals with washing after treatment and none of the three animals without washing after treatment showed Fluorescein stain on the cornea.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: None of the three animals with washing after treatment and none of the three animals without washing after treatment showed Fluorescein stain on the adnexa. 1 hour after treatment the adnexa showed a slight erythema.
- Irritation parameter:
- iris score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- Irritation, limited to erythema of the adnexa, resolved after one hour. No adnexal or corneal staining was observed. Immediate washing was beneficial.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based upon the findings of this study, test item is slightly irritating to the eyes of rabbits. However, the criteria for classification and labelling according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 are not met.
- Executive summary:
The eye irritation test was performed onto both eyes of 3 rabbits; in one eye of each rabbit, the material was immediately rinsed with water, while in the other eye, the material remained without washing. Immediately after instillation, slight erythema was observed that was limited to the adnexa, and washing was palliative. No adnexal or corneal staining was observed.
Based on the results observed in the present study, the criteria for classification and labelling according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 are not met.
Reference
A very minor eye irritant.
The compound was a slight eye irritant when tested in six rabbit eyes (three washed and three unwashed). Irritation, limited to erythema of the adnexa, resolved after one hour. No adnexal or corneal staining was observed. Immediate washing was beneficial.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
skin irritation
A skin irritation test in guinea pigs was performed. The compound was a moderate skin irritant when applied to the depilated guinea pig abdomen under an occlusive wrap for 24 hours. It produce moderate erythema, edema and some necrosis. Thin eschars at one week, light scarring desquamation and alopecia at 2 weeks.
Eye irritation
Eye irritation was tested in three rabbits. The eye irritation test was performed onto both eyes of 3 rabbits; in one eye of each rabbit, the material was immediately rinsed with water, while in the other eye, the material remained without washing. Immediately after instillation, slight erythema was observed that was limited to the adnexa, and washing was palliative. No adnexal or corneal staining was observed.
Justification for classification or non-classification
According to the criteria of Classification, Labelling and Packaging of Substances and Mixtures Regulation (EC) No 1272/2008 (CLP Regulation), p-diisopropylbenzene is classified as Skin irritant Cat 2 (H315: Causes skin irritation.).
However, p-diisopropylbenzene does not satisfy the criteria for classification as an ocular irritant according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 or UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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