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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-442-1 | CAS number: 95-70-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-07-04 to 2006-05-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-conform study under GLP without deviations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- -0.321
- Temp.:
- 25 °C
- pH:
- ca. 8.4
- Remarks on result:
- other: SD = +/-0.021
- Type:
- Pow
- Partition coefficient:
- 0.478
- Temp.:
- 25 °C
- pH:
- ca. 8.4
- Remarks on result:
- other: SD = +/-0.023
- Conclusions:
- log Pow = - 0.321 ± 0.021 at 25°C ± 1°C.
- Executive summary:
The partition coefficient (Pow) of Toluene-2,5-diamine (A005) was estimated according to the test guidelines described in OECD Guideline No. 107, "shake-flask method". The partition coefficient Toluene-2,5-diamine (A005) was estimated to be 0.1 by the Sponsor.
For the definitive estimation, three series of duplicate measurements were performed in different volumes of a stock solution in n-octanol (presaturated with buffer pH = 8.5) which were shaken with different volumes of buffer pH = 8.5 (presaturated with n-octanol). After centrifugation, both organic and aqueous phases were analyzed by High Performance Liquid Chromatography with Ultra-Violet detection (HPLC/UV). The partition coefficients were calculated, for each ratio tested, from the measured concentration of Toluene-2,5-diamine (A005) in the organic and aqueous phases.
The resulting log Pow = - 0.321 ± 0.021 at 25°C ± 1°C.
Reference
Description of key information
Substance 2-methyl-p-phenylenediamine has a log Pow = - 0.321 ± 0.021 at 25°C ± 1°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.321
- at the temperature of:
- 25 °C
Additional information
A Klimisch-1-rated study was being conducted in 2006. The partition coefficient (Pow) of 2-methyl-p-phenylenediamine was estimated according to the test guidelines described in OECD Guideline No. 107, "shake-flask method". The resulting log Pow = - 0.321 ± 0.021 at 25°C ± 1°C (Pow = 0.478).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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