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Diss Factsheets
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EC number: 200-157-7 | CAS number: 52-89-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In vitro studies with L-Cysteine hydrochloride gave inconsistent results. A reverse mutation assays using different strains of Salmonella typhimurium according to Ames a positive response in 2 out of 6 tested strains was observed. In a mammalian cell gene mutation assay using Chinese hamster lung fibroblasts
(V79), genotoxicity of L-cysteine hydrochloride was also positive.
In an in vitro cytogenetic test with human blood cells L-Cysteine HCl was not mutagenic.
In vitro studies on genotoxicity can be classified as screening tests. Therefore some oversensivity seems acceptable.
Genetic toxicity in vivo
Description of key information
For the evaluation of a genotoxic risk of humans in vivo studies are much more relevant and decicive. An in vivo micronucleus test with mouse bone marrow cells revealed that the substance L-Cysteine hydrochloride is not mutagenic for mammals. Additionally a carcinogenicity test gave no indication of a carcinogenic action of L-Cysteine hydrochloride. The results of these two studies demonstrate, that L-Cysteine hydrochloride is not genotoxic.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
For classification and non-classification test results from in vivo studies are relevant. An in vivo micronucleus test with mouse bone marrow cells revealed that the substance L-Cysteine hydrochloride is not mutagenic for mammals. According to Regulation (EC) No.: 1272/2008 and subsequent regulations, the L-Cysteine hydrochloride as well as the monohydrate form is not classified with regard to genetic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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