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EC number: 258-799-9 | CAS number: 53817-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1975-12-15 to 1977-06-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report, study however disregarded as intraperitoneal application is no appropriate route of test item exposure.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to BASF internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-amino-N-(2-ethylhexyl)benzenesulphonamide
- EC Number:
- 258-799-9
- EC Name:
- 4-amino-N-(2-ethylhexyl)benzenesulphonamide
- Cas Number:
- 53817-09-7
- Molecular formula:
- C14H24N2O2S
- IUPAC Name:
- 4-amino-N-(2-ethylhexyl)benzene-1-sulfonamide
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males 20 g, females 26 g
- Diet: The animals were offered a standardized animal laboratory diet Altromin R 1324 (Altromin GmbH, Lage, Germany)
IN-LIFE DATES: From: 1977-06-29 To: 1977-07-13
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- VEHICLE
- Concentration in vehicle: Test concentration used: 15 %, 14.7 %, and 10 % (G/V)
- Amount of vehicle (if gavage): males 0.29 mL, females 0.37 mL
MAXIMUM DOSE VOLUME APPLIED: males: 14.32 mL/kg bw
DOSAGE PREPARATION: Suspension in 0.5% aqueous CMC preparation with 2 - 3 drops Cremophor EL - Doses:
- 1000, 1470, 2150 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Other examinations performed: clinical signs, body weight
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: normal weight development reported, however no further details are given
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs (dyspnoe, apathy, dorsal or lateral position, tumbling, atony, narcotic-like state, spasmodic behaviour, tonic spasms, lacrimation, poor general condition, skin/fur, tremor, feces, urine)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1000 mg/kg: 2/10 after 14 days; 1470 mg/kg: 8/10 after 14 days; 2150 mg/kg: 10/10 after 14 days
- Clinical signs:
- Dyspnea, apathy, abdominal and lateral position, staggering, atony, partly narcotic-like state, missing pain and cornea reflexes, spastic gait, tonic spasms, lachrymation, poor general state.
- Body weight:
- Normal body weight growth
- Gross pathology:
- Intra-abdominal substance residues and adherences, liver with slightly rounded edges
Any other information on results incl. tables
Table: Number of dead animals after respective exposure duration
Dose (mg/kg bw) |
Test item conc. (%) |
No. of animals |
1 h |
24 h |
48 h |
7 d |
14 d |
2150 |
15 |
5 M |
0 |
5 |
5 |
5 |
5 |
2150 |
15 |
5 F |
0 |
5 |
5 |
5 |
5 |
1470 |
14.7 |
5 M |
0 |
2 |
3 |
3 |
3 |
1470 |
14.7 |
5 F |
0 |
5 |
5 |
5 |
5 |
1000 |
10 |
5 M |
0 |
0 |
1 |
1 |
1 |
1000 |
10 |
5 F |
0 |
0 |
1 |
1 |
1 |
Applicant's summary and conclusion
- Executive summary:
The study was performed to determine the acute toxicity following intraperitoneal administration of the test item, applied as a suspension in CMC, in NMRI mice. The study procedure was based on the BASF internal testing standards. To a group of 30 fasted animals (5 males, 5 females per dose level) a single oral dose of the test material preparation at dose level of 1000, 1470, and 2150 mg/kg bw was given. Mortalities occurred. Other signs of toxicity were dyspnea, apathy, abdominal and lateral position, staggering, atony, partly narcotic-like state, missing pain and cornea reflexes, spastic gait, tonic spasms, lachrymation, poor general state. The expected body weight gain has been observed in the course of the study. Effects noted at necropsy were intra-abdominal substance residues and adherences, and liver with slightly rounded edges. Under the conditions of this study the median lethal concentration of the test item after intraperitoneal application was found to be ca. 1200 mg/kg bw. for the male and female animals. The study however was disregarded, as an oral acute toxicity study with the rat is available, which is considered to be the key study as it delivers the more appropriate data for the use in classification and labelling and chemical safety assessment.
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