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Diss Factsheets
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EC number: 203-581-0 | CAS number: 108-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Rationale for reliability incl. deficiencies:
- other: Reliable with restrictions.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Uptake, Elimination, and Bioconcentration of ten Anilines in Zebrafish (Brachydanio rerio)C
- Author:
- Kalsch, W. et al.
- Year:
- 1 991
- Bibliographic source:
- Chemosphere. Vol.22. Nos 3-4, pp. 351-363, 1991
- Reference Type:
- publication
- Title:
- Comparison of BCF Models based on log P
- Author:
- Devillers, J. et al.
- Year:
- 1 996
- Bibliographic source:
- Chemosphere, Vol. 33, No. 6, pp. 1047-1065, 1996
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Test material form:
- other: liquid
- Details on test material:
- - Purity not reported
- Empirical formula: C6H6ClN
- Molecular mass: 127.58 g/mole
Constituent 1
Sampling and analysis
- Details on sampling:
- Exposure was performed under static conditions in a closed basin with 60 fishes and 5000 mL of carbon filtered tap water, (Hardness 230 ± 20 mg/L as CaO, pH 8.1 ± 0.1 at 26 ± 1 °C). 100 mg/L streptomycine sulfate were added. Fishes were not fed during exposure. The water was aerated and waste was passed through toluene to detect evaporated anilines and through KOH solution (10 % w/v) to collect 14CO2. Water, toluene, and KOH samples were taken several times during exposure and examined for radioactivity. Activity in water was kept constant (± 10%) during exposure. Ten samples at three fishes each were taken to examine the kinetics of uptake. Steady state was considered to be reached when activity was constant in at least three samples. The remaining 30 fishes were then transferrecl to the elimination basin, where tap water was passed through (10 L/h for the first ten hours, 2 L/h thereafter). Sampies taken during elimination (three fishes each) were treated in the same way as decribed above.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Adult male artd female zebrafish (Brachydanio rerio) from West Aquarium, Bad Lauterberg, Gemany were used.
Their wet weight ranged from 150 to 450 mg.
3-chloroaniline tested was rin-14C labelled compound
Study design
- Route of exposure:
- aqueous
- Test type:
- static
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- h
- Total depuration duration:
- 52 h
Test conditions
- Hardness:
- 23 °dH (230 ± 20 mg/L CaO)
- Test temperature:
- 26 ± 1 °C
- pH:
- 8.1 ± 0.1
- Nominal and measured concentrations:
- Concentration of 3-chloroaniline in water during exposure: 0.17 µmol/L = 0.022 mg/L
Concentration (activity) in fish at the end of the elimination period: 10.3 % - Details on estimation of bioconcentration:
(2)
Results and discussion
Bioaccumulation factor
- Type:
- BCF
- Value:
- 11.5 dimensionless
- Basis:
- other: estimation
- Time of plateau:
- 100 h
- Calculation basis:
- steady state
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The bioaccumulation of 3-chloroaniline was calculated by 11.5.
- Executive summary:
The bioaccumulation of 3-chloroaniline was calculated by 11.5.
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