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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Four studies are available investigating the aquatic toxicity of Glycerides, C16-18 (even numbered) mono- and di- and their citrates (EC 701-358-7) to freshwater fish, aquatic invertebrates, algae and aquatic plants. In order to fulfil the standard information requirements and to strengthen the overall dataset, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from a structurally related substance, Glycerides, C16 - 18 (even numbered) mono-, di-, and tri-, hydrogenated, citrates, potassium salt (CAS 917440-38-6), was conducted.
All experimental studies available for the target substance and the suitable source substance were performed according to internationally accepted guidelines and GLP. They cover four trophic levels of an aquatic ecosystem. No toxicity was observed up to the limit of water solubility (129 µg/L) in all available experimental studies.
The short-term toxicity to fish was determined in a limit test according to OECD 203 for the target substance. The test item concentrations could not be analytically quantified during the whole experiment as all measured concentrations were below the Limit of Quantification (LOQ = 0.038 mg/L). Therefore, all results are expressed as the nominal loading rate WAF. No effects were observed after 96 h exposure with the tested concentration. Therefore, a LL50 (96 h) of > 100 mg/L (nominal) was derived. This result is supported with a study for a structurally and chemically related source substance. The short-term toxicity to fish was determined in a limit test according to OECD 203 for the source substance Glycerides, C16 - 18 (even numbered) mono-, di-, and tri-, hydrogenated, citrates, potassium salt (CAS 917440-38-6). No mortality was observed after 96 h for the tested concentration. Therefore, a LL50 (96 h) of > 100 mg/L (nominal) was derived.
Long-term toxicity testing to fish was not considered to be necessary since there was no toxicity to fish observed in the available acute tests and there was no evidence from the available data that fish are more sensitive compared to aquatic invertebrates or algae. Thus, in order to avoid unnecessary vertebrate testing, no additional long-term test with fish was proposed.
One short-term toxicity test on aquatic invertebrates is available for the target substance. No effects were observed after 48 h at the tested concentration. Therefore, an EC50 (48 h) of > 0.214 mg/L (measured geom. mean) was derived. Since the target substance is poorly soluble in water a testing proposal is submitted in order to investigate chronic effects to aquatic invertebrates. This approach is in line with Annex VII of Regulation (EC) No 1907/2006.
The toxicity to algae was conducted for the source substance Glycerides, C16 - 18 (even numbered) mono-, di-, and tri-, hydrogenated, citrates, potassium salt (CAS 917440-38-6). No effects on algae are expected up to the limit of its water solubility (ErL50 (72 h) > 100 mg/L (nominal), and NOELR (72 h) ≥ 100 mg/L (nominal) (Pseudokirchneriella subcapitata).
In addition, the toxicity of the target substance to Lemna gibba was assessed. The test item concentration could not be analytically quantified during the whole experiment as all measured concentrations were below the Limit of Quantification (LOQ = 0.038 mg/L). Therefore, all results are expressed as the nominal loading rate WAF. No inhibition was observed after 7 d for the tested concentration. Therefore, an EL50 (7 d) of > 100 mg/L (nominal) and a NOEC (7 d) of ≥ 100 mg/L (nominal) was derived.
The degradation process in commercial sewage treatment plants is not expected to be inhibited by the target substance. A toxicity control from a biodegradation study performed according to OECD 301 F for the source substance Glycerides, C16-18 and C18-unsatd. mono- and di-, citrates did not indicate any inhibition of biodegradation up to a concentration of 22 mg/L (NOEC (14 d) of ≥ 22 mg/L BOD).
Based on the results from the target substance and from a structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that the target substance Glycerides, C16-18 (even numbered) mono- and di- and their citrates exhibits no toxic effects on freshwater organisms up to the limit of the water solubility (129 µg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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