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EC number: 252-036-3 | CAS number: 34451-19-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1989 to 1989-11-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted in Feb 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Butyl (S)-2-hydroxypropionate
- EC Number:
- 252-036-3
- EC Name:
- Butyl (S)-2-hydroxypropionate
- Cas Number:
- 34451-19-9
- Molecular formula:
- C7H14O3
- IUPAC Name:
- butyl 2-hydroxypropanoate
Constituent 1
- Specific details on test material used for the study:
- - Name used in the study report: (S (-) - Butyl lactate)
- Trade Name: Purasolv BL
- Batch No.: BU 021F
- Purity: min. 97%
- Appearance: clear, colourless liquid
- CAS No.: CAS: 138-22-7 (although this is the CAS number for butyl lactate of unspecified stereochemistry, the substance is clearly identified as the S-enatiomer)
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeding Center for Laboratory Animals 'Charles River Wiga GmbH, Sulzfeld, F.R., Germany
- Age at study initiation: 6 weeks
- Weight at study initiation: 161-188 g for males and 126-139 g for females
- Number of animals: 5 females, 5 males
- Housing: in groups of 5 animals, stainless cages with wire-screen bottom
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70 %
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 % (w/v)
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: No data - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- The rats were observed frequently for signs of intoxication during the first 4 post-treatment hours and later on, at least once daily, throughout an observation period of 14 days. Individual body weights were recorded on day 0, 3, 7 and 14. At the end of the observation period, the rats were killed for macroscopic examination. No microscopic examination was performed.
- Statistics:
- No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: At 1, 4 and 24 h after treatment all animals showed moderate piloerection, which was not observed 48 h afterwards. At 4 h post treatment all animals showed moderate signs of diarrhoea, which were not observed 24 h after treatment.
- Gross pathology:
- No treatment-related gross lesions were observed.
- Other findings:
- No other findings
Any other information on results incl. tables
Table 1: Summary of dose applied, mortality and mean body weights on day 0, 3, 7 and 14 after exposure to butyl-S-lactate:
Sex |
Test concentration [mg/kg] |
Mean body weight [g] on day |
Mortality per 5 animals |
|||
0 |
3 |
7 |
14 |
|||
Male |
2000 |
174 |
324 |
238 |
267 |
0/5 |
Female |
2000 |
131 |
156 |
163 |
172 |
0/5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Butyl-S-lactate is not acutely toxic when administered to rats by gavage, at a single dose of 2000 mg/kg bw. The LD50 is greater than 2000 mg/kg bw for both sexes.
- Executive summary:
In an acute oral toxicity study conducted according to OECD guideline 401, groups of Wistar rats (5/sex) were given butyl-S-lactate (min. 97 % purity) as a single oral dose of 2000 mg/kg bw in maize oil. The animals were observed for 14 days after the single exposure. No mortalities occurred. Therefore, the oral LD50 value is greater than 2000 mg/kg bw, both in male and female rats.
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