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EC number: 224-662-7 | CAS number: 4441-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1st November 2001 - 17th January 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Trimorpholinophosphine oxide
- EC Number:
- 224-662-7
- EC Name:
- Trimorpholinophosphine oxide
- Cas Number:
- 4441-12-7
- Molecular formula:
- C12H24N3O4P
- IUPAC Name:
- trimorpholinophosphine oxide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: F. Winkelmann, 33178 Borchen
- Age at study initiation: about 6 weeks
- Weight at study initiation: 154 - 179 g (range)
- Fasting period before study: yes, overnight (17 hours before - 4 h after treatment)
- Housing: the rats were housed in an air-conditioned room of ca. 25 m² in the Institute of Toxicology in Macrolon cages type III with a shelter, placed on mobile racks. Animals were kept on conventional softwool granulate as bedding which was changed 2x per week.
- Diet: Long Life for mice and rats, 9439 Eberle, Nafag, ad libitum
- Water: tap water from Makrolon drinking bottles, ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
- Humidity (%): 46-58
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 21 November To: 28 November 2001
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 20 mL/kg bw
Directly before the preparation the test metariel was solved in the vehicle using a shaking device (Vortex Genie)
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
The behaviour and general condition of all animals was monitored for at least 6 h after administration of the test material and then checked daily. All animals were weighed before treatment and on days 2, 4, 6, 8, 11, 13, and 15 of the experimental part.
- Necropsy of survivors performed: yes, all surviving animals were sacrificed at the end of the experimental period by CO2 asphyxia and subjected to gross pathological investigation. - Statistics:
- Body weight data were recorded with the PC software "akudat", the statistical evaluation of the body weight were carried out with the software "Tox 511A", the body weight development of each rat and group was determined. The group mean value was calculated for each measurement.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- corresponds to ATC class 0
- Mortality:
- There was no mortality during the study period.
- Clinical signs:
- No clinical signs were observed during the study period.
- Body weight:
- Body weight development of the treated rats was inconspicuous.
- Gross pathology:
- Necropsy revealed no substance-related findings.
Any other information on results incl. tables
Table 1: Mortality and clinical signs during the study period
Dose |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Males & Females |
||||
2000 |
0/0/6 |
--- |
--- |
0 |
LD50 > 2000 mg/kg bw |
* first number = number of dead animals
second number = number of animals with clinical signs
third number = number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- CLP: not classified
- Executive summary:
According to the results of the study, the test material can be allocated to ATC class 0, i.e. the LD50 value is expected to exceed 2000 mg/kg bw.
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