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EC number: 211-661-1 | CAS number: 682-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent study performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2-bis(allyloxymethyl)butan-1-ol
- EC Number:
- 211-661-1
- EC Name:
- 2,2-bis(allyloxymethyl)butan-1-ol
- Cas Number:
- 682-09-7
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 2,2-bis[(prop-2-en-1-yloxy)methyl]butan-1-ol
- Details on test material:
- The test item is registered under the trade name, trimethylolpropane diallyl ether 90 (TMPDE 90). The actual composition of the test item is trimethylolpropane diallyl ether, 90.7%, trimethylolpropane monoallyl ether, 5.2 % and trimethylolpropane triallyl ether, 3.9%.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No further details
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable
Test solutions
- Vehicle:
- no
- Details on test solutions:
- 5006 mg of the test item was dissolved in 1000 mL of test water (dilution water) by magnetic stirring on the day of the test start. The stock solution (approx 5000 mg/l) was diluted with reconstituted test water in order to prepare the test solutions.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The test organisms are 6 to 24 hours old, which are incubated for48 hours in a gradient of the test item.The animals were taken from Toxicon's continuous culture of Daphnia magna. The culture originates from NIVA, Norway and is on working days fed with approximately 50-75 mL green algae Pseudokirchneriella subcapitata.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No post exposure observation period.
Test conditions
- Hardness:
- 250±25 mg/l
- Test temperature:
- 21±1 ⁰C
- pH:
- The pH was measured at the start and the end of the experiment. pH at the start ranged between 7.66 and 7.99, and between 8.04 and 8.07 at the end of the exposure period.
- Dissolved oxygen:
- The dissolved oxygen (DO) concentration was measured at the start and the end of the experiment. DO at the start ranged between 96.2 and 97.6%, and between 99.4 and 100.6% at the end of the exposure period.
- Salinity:
- Not stated.
- Nominal and measured concentrations:
- The nominal concentrations of the test item in the test solutions were 25, 50, 100, 200 and 400 mg/L.
- Details on test conditions:
- The animals were incubated in glass Petri dishes (50 mL) with 25 mL solution. Four replicates with five animals in each replicate were used for the both the test concentrations and for the control. The dishes were incubated in a thermo constant room at temperature 21±1 ⁰C and subdued light with the light rhythmof 16 hours light: 8 hours darkness.
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 189 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- An EC50 value of 189 mg/L was determined for the 48 hours of exposure for the test item TMPDE 90.
- Results with reference substance (positive control):
- A qualification test on the Daphnia magna culture was made on 15 May 2008 to assure the quality of the test animals. EC50 was 1.1 mg/L, which confirmed that the culture was suitable as a test organism.
- Reported statistics and error estimates:
- No reported stastics and error estimates.
Any other information on results incl. tables
Immobility after 24 hours exposure in the control, 25, 50, 100, 200 and 400 mg/L treatments was 0, 5, 0, 10,40 and 25%.
Immobility after 48 hours exposure in the control, 25, 50, 100, 200 and 400 mg/L treatments was 0, 5, 0, 10, 55 and 100%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The toxicity of TMPDE 90 to the water flea, Daphnia magna, was determined in the 48 hour acute immobilisation test conducted according to OECD 202. The daphnids were exposed to concentrations of TMPDE 80 between 25 and 400 mg/L. The 48 hour EC50 was calculated to be 189 mg/L (based on nominal exposure concentrations). The corresponding NOEC was 100 mg/L.
- Executive summary:
The toxicity of TMPDE 90 to the water flea, Daphnia magna, was determined in the 48 hour acute immobilisation test conducted according to OECD 202. The daphnids were exposed to concentrations of TMPDE 90 between 25 and 400 mg/L. The 48 hour EC50was calculated to be 189 mg/L (based on nominal exposure concentrations). The corresponding NOEC was 100 mg/L.
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