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Diss Factsheets
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EC number: 203-919-7 | CAS number: 111-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Standard well reported study conducted according to GCP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
- Type of study / information:
- Skin tolerability
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Evaluation of cutaneous irritation after a single application of test substance under occlusion for 48 consecutive hours in healthy volunteers.
- GLP compliance:
- yes
- Remarks:
- Good Clinical Practice
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethanol
- EC Number:
- 203-919-7
- EC Name:
- 2-(2-ethoxyethoxy)ethanol
- Cas Number:
- 111-90-0
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Transcutol
- Physical state: Translucent liquid
- Lot/batch No.: 75412
- Storage condition of test material: Minimum 19C
Constituent 1
Method
- Ethical approval:
- confirmed and informed consent free of coercion received
- Details on study design:
- Test substance is applied once only. After 48hrs the patches are removed and any remaining test substance on the surface of the treated area eliminated using a hydrophilic square pad. The cutaneous examinations were performed about 30 minutes after removal of the patches.
As well as the test substance , test chambers without the test article were also applied under the same conditions to act as negative control.
Standard inclusion/exclusion criteria applied to the volunteers. - Exposure assessment:
- estimated
- Details on exposure:
- Application of test substance, about 0.02 ml per volunteer in a 10% (w/v) dilution in sterile water, on a surface of about 50mm2 located to the left of the spine. The test substance was placed in a 'Finn Chamber' which is an isolation chamber that ensures a good occlusion limited to the application area of the test substance. It is composed of an aliminium disc 8mm in diameter covering a contact surface of 50mm2. Each disc is individually mounted onto an adhesive tape. The test liquid is applied first onto a disc of filter paper (7mm) previously inserted into the disc, so that it absorbs a volume of about 0.02ml.
Results and discussion
- Results:
- 14 volunteers were recruited and selected for the realisation of the study.
10 of them came to the testing facility and all were admitted and participated in the whole study. Their ages were from 19 to 41 years old.
No reaction of pathological irritation or significant cutaneous intolerance was noted.
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- The test substance was well tolerated under the conditions of this study
- Executive summary:
The single epicutaneous application of 0.02ml of 2 -(2 -ethoxyethoxy)ethanol at 10% w/v in water under an occlusive patch test
for 48hrs in 10 healthy adult volunteers was well tolerated and shows low irritancy potential.
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