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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Monitoring data
Administrative data
- Endpoint:
- monitoring data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 32645.
- Version / remarks:
- 2008-11 Chemical analysis - Decision limit, detection limit and determination limit under repeatability
conditions - Terms, methods, evaluation - Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- EU monitoring guidance (Guidance document no. 32 on biota monitoring, Technical Report - 2014 - 083;
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of measurement:
- other: Concentrations measured in samples collected from different rivers in Europe
- Media:
- surface water
Test material
- Details on test material:
- - Supplier: Aldrich Chemical Company, Inc., Gillingham UK
Constituent 1
- Specific details on test material used for the study:
- The transformation products also measured: MME-TBBPA and DME-TBBPA
Study design
- Details on sampling:
- The fish, SPM and sediment samples analysed for the test items were from the stock of the German Environmental Specimen Bank (ESB).
Fish samples were collected in different rivers in Europe and the Lake Belau in Germany. The fish samples were bream and sole muscle tissues (filets).
Bream (Abramis brama) is quite common in central, south and north European countries. It is a non-migrating bottom feeder fish and is widely used as monitoring organism. In addition, sole samples (Solea solea) from the Western Scheldt area in The Netherlands were analyzed as well. Muscle tissues (filets) were analyzed in the monitoring study as filet is one of the standard tissues used for the environmental monitoring of chemicals in fish (especially for lipophilic compounds). To compare tissues with different fat contents a normalization to the fat content can be performed.
Results and discussion
Concentrationopen allclose all
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- substance
- Remarks:
- Bream muscle 2007-2013
- Conc.:
- >= 0.36 - <= 0.45 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.45 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Mersey
- Substance or metabolite:
- substance
- Remarks:
- Bream muscle 2007 2013i
- Conc.:
- >= 0.22 - <= 1.19 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.45 μg/kg ww
- Key result
- Country:
- Sweden
- Location:
- River Götaälv
- Substance or metabolite:
- substance
- Remarks:
- Bream muscle 2007-2013
- Conc.:
- >= 0.08 - <= 0.33 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.45 μg/kg ww
- Key result
- Country:
- France
- Location:
- River Rhone
- Substance or metabolite:
- substance
- Remarks:
- Bream muscle 2007-2013
- Conc.:
- >= 0.24 - <= 0.76 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.45 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Tees
- Substance or metabolite:
- substance
- Remarks:
- Bream muscle 2007-2013
- Conc.:
- >= 0.31 - <= 1.91 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.45 μg/kg ww
- Key result
- Country:
- Germany
- Location:
- Lake Belau
- Substance or metabolite:
- substance
- Remarks:
- Bream muscle
- Conc.:
- >= 0.22 - <= 0.45 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.45μg/kg ww
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- substance
- Remarks:
- Bream muscle 2007-2013
- Conc.:
- >= 0.47 - <= 0.73 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.45 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Mersey
- Substance or metabolite:
- substance
- Remarks:
- SPM 2008
- Conc.:
- 9.44 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.45 μg/kg dw
- Key result
- Country:
- Sweden
- Location:
- River Götaälv
- Substance or metabolite:
- substance
- Remarks:
- SPM 2008
- Conc.:
- 1.99 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.45 μg/kg dw
- Key result
- Country:
- France
- Location:
- River Rhoe
- Substance or metabolite:
- substance
- Remarks:
- SPM 2008-2014
- Conc.:
- >= 1.83 - <= 1.93 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.45 μg/kg dw
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Tees
- Substance or metabolite:
- substance
- Remarks:
- SPM 2008-2014
- Conc.:
- >= 2.28 - <= 3.97 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.45 μg/kg dw
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- substance
- Remarks:
- SPM 2008-2014
- Conc.:
- >= 0.09 - <= 0.53 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.45 μg/kg dw
- Key result
- Country:
- Germany
- Location:
- Lake Belau
- Substance or metabolite:
- substance
- Remarks:
- Sediment cores 2012-2014
- Conc.:
- >= 2.3 - <= 2.58 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.45 μg/kg dw
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Bream muscle 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.8 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Mersey
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Beram muscle 2007-2013
- Conc.:
- >= 0 - <= 1.63 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.8 μg/kg ww
- Key result
- Country:
- Sweden
- Location:
- River Götaälv
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Bream muscle 2007-2013
- Conc.:
- >= 0 - <= 0.37 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.8 μg/kg ww
- Key result
- Country:
- France
- Location:
- RiverRhone
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Bream muscle 2007-2013
- Conc.:
- >= 0 - <= 0.61 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.8 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Tees
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Bream muscle 2007-2013
- Conc.:
- >= 0.83 - <= 1.83 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.8 μg/kg ww
- Key result
- Country:
- Germany
- Location:
- Lake Belau
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Bream muscle 2007-2013
- Conc.:
- >= 0.24 - <= 1.43 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.8 μg/kg ww
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Sole muscle 2007-2013
- Conc.:
- >= 0.59 - <= 1.84 other: μg/kg ww
- Remarks on result:
- other: LOQ = 0.8 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Mersey
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME SPM 2008
- Conc.:
- 4.48 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.8 μg/kg dw
- Key result
- Country:
- Sweden
- Location:
- River Götaälv
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME SPM 2008
- Conc.:
- 2.32 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.8 μg/kg dw
- Key result
- Country:
- France
- Location:
- River Rhone
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME SPM 2008-2014
- Conc.:
- >= 2.59 - <= 3.85 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.8 μg/kg dw
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Tees
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME SPM 2008-2014
- Conc.:
- >= 2.85 - <= 3.36 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.8 μg/kg dw
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME SPM 2008-2014
- Conc.:
- >= 0 - <= 0.04 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.8 μg/kg dw
- Key result
- Country:
- Germany
- Location:
- Lake Belau
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-MME Sediment cores 2012-2014
- Conc.:
- >= 5.16 - <= 5.51 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.8 μg/kg dw
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME Bream muscle 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 1.6 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Mersey
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME Bream muscle 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 1.6 μg/kg ww
- Key result
- Country:
- Sweden
- Location:
- River Götaälv
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 1.6 μg/kg ww
- Key result
- Country:
- France
- Location:
- River Rhone
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME Bream muscle 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 1.6 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Tees
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME Bream muscle 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 1.6 μg/kg ww
- Key result
- Country:
- Germany
- Location:
- Lake Belau
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME Bream muscle 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 1.6 μg/kg ww
- Key result
- Country:
- Netherlands (the)
- Location:
- Westran scheldt
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME Sole muscle 2007-2013
- Conc.:
- 0 other: μg/kg ww
- Remarks on result:
- other: LOQ = 1.6 μg/kg ww
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Mersey
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME SPM 2008
- Conc.:
- 0.65 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.7 μg/kg dw
- Key result
- Country:
- Sweden
- Location:
- River Götaälv
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME SPM 2008
- Conc.:
- 0 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.7 μg/kg dw
- Key result
- Country:
- France
- Location:
- Rver Rhone
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME SPM 2008-2014
- Conc.:
- 0 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.7 μg/kg dw
- Key result
- Country:
- United Kingdom of Great Britain and Northern Ireland (the)
- Location:
- River Tees
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME SPM 2008-2014
- Conc.:
- >= 0.01 - <= 0.55 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.7 μg/kg dw
- Key result
- Country:
- Netherlands (the)
- Location:
- Western Scheldt
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME SPM 2008-2014
- Conc.:
- 0 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.7 μg/kg dw
- Key result
- Country:
- Germany
- Location:
- Lake Belau
- Substance or metabolite:
- metabolite
- Remarks:
- TBBPA-DME Sediment cores 2012-2014
- Conc.:
- 0 other: μg/kg dw
- Remarks on result:
- other: LOQ = 0.7 μg/kg dw
- Details on results:
- The method was applied to the analysis of TBBPA, TBBPA-MME and TBBPA-DME in 43 fish samples, 14 SPM and 2 sediment samples.
TBBPA could be quantified in 13 of 36 bream samples (range ~ 0.5 - 1.2 μg/kg ww) and 7 of 7 sole muscle samples (range ~ 0.5 – 0.7 μg/kg ww). Further, it could be quantified in 11 of the 14 SPM samples (range ~ 0.5 – 9.4 μg/kg dw) and in both of the sediment core samples (2.3 – 2.6 μg/kg dw).
TBBPA-MME could be quantified in 12 of 36 bream and 4 of 7 sole muscle samples (range ~ 0.8 – 1.8 μg/kg ww). Further, it could be quantified in 10 of the 14 SPM samples (range ~ 2.3 – 4.5 μg/kg dw) and in both of sediment core samples (5.2 – 5.5 μg/kg dw).
Dimethyl-TBBPA was only rarely detectable and could be quantified above the LOQ in no sample.
Each fish sample was a composite of musculature from about 15 fish. After sampling, the samples were ground at low temperatures using a liquid nitrogen cooled mill until about 90% of the material developed grain sizes below 200 μm (D90 = 200 μm). The samples available were homogenates from each year. They were stored over liquid nitrogen until analysis.
Samples of Suspended Particulate Matter (SPM) were collected using stainless steel traps exposed in the rivers Western Scheldt (The Netherlands), Tees and Mersey (Great Britain), Rhone (France) and Götaälv (Sweden). The traps were sampled every three month resulting in 4 subsamples per year. These were combined to one composite sample per year. TheGötaälv and Mersey SPM samples were sampled only once per year. After sampling, the SPM samples were freeze dried, sieved (2 mm) and stored over liquid nitrogen until analysis.
Applicant's summary and conclusion
- Conclusions:
- The method was applied to the analysis of TBBPA, TBBPA-MME and TBBPA-DME in 43 fish samples, 14 SPM and 2 sediment samples.
TBBPA could be quantified in 13 of 36 bream samples (range ~ 0.5 - 1.2 μg/kg ww) and 7 of 7 sole muscle samples (range ~ 0.5 – 0.7 μg/kg ww). Further, it could be quantified in 11 of the 14 SPM samples (range ~ 0.5 – 9.4 μg/kg dw) and in both of the sediment core samples (2.3 – 2.6 μg/kg dw).
TBBPA-MME could be quantified in 12 of 36 bream and 4 of 7 sole muscle samples (range ~ 0.8 – 1.8 μg/kg ww). Further, it could be quantified in 10 of the 14 SPM samples
(range ~ 2.3 – 4.5 μg/kg dw) and in both of sediment core samples (5.2 – 5.5 μg/kg dw).
Dimethyl-TBBPA was only rarely detectable and could be quantified above the LOQ in no sample. - Executive summary:
The method was applied to the analysis of TBBPA, TBBPA-MME and TBBPA-DME in 43 fish samples, 14 SPM and 2 sediment samples.
TBBPA could be quantified in 13 of 36 bream samples (range ~ 0.5 - 1.2 μg/kg ww) and 7 of 7 sole muscle samples (range ~ 0.5 – 0.7 μg/kg ww). Further, it could be quantified in 11 of the 14 SPM samples (range ~ 0.5 – 9.4 μg/kg dw) and in both of the sediment core samples (2.3 – 2.6 μg/kg dw).
TBBPA-MME could be quantified in 12 of 36 bream and 4 of 7 sole muscle samples (range ~ 0.8 – 1.8 μg/kg ww). Further, it could be quantified in 10 of the 14 SPM samples
(range ~ 2.3 – 4.5 μg/kg dw) and in both of sediment core samples (5.2 – 5.5 μg/kg dw).
Dimethyl-TBBPA was only rarely detectable and could be quantified above the LOQ in no sample.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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