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Diss Factsheets
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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The study carried out on Pseudomonas putida, but with methyl salicylate (Sternalski, 1992), has been selected as key study. This study, performed according to the draft of the norm ISO/CD 10712 (1990-10-10), evaluated the inhibitory effect of freshly prepared and aged (120h) methyl salicylate solutions, after 16h incubation in liquid medium. Methyl salicylate is known to slowly hydrolyse in salicylic acid. The decrease in pH of the aged test solutions, together with a slight decrease in toxicity, led to the hypothesis that salicylic acid or a mixture of salicylic acid with methyl salicylate may have been tested in aged solutions. Since the two other reliable studies performed with salicylic acid showed no effect at the highest tested concentrations, the 16h EC10 value (=162 mg/L ) obtained on aged methyl salicylate solutions has been used as a surrogate and worst case data for deriving properly the PNEC STP.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 162 mg/L
Additional information
Two other key studies quoted as Klimisch 2 have been also recorded. The first one (Klecka and Landi, 1985) has been performed according to the OECD 209 guideline : "activated sludge, respiration inhibition test". The IC50-3h obtained was > 1000 mg/L (no NOEC or EC10 was determined).The second study (Henschel et al., 1997) is a 48-h acute toxicity test on the ciliate Tetrahymena pyriformis according to a draft of the OECD guideline (Pauli, 1996). The IC50-48h value obtained was > 100 mg/L (no effect observed at this concentration). Based on the absence of concentration effect value for salicylic acid in several studies, a read-across approach has been applied with methyl salicylate and the study of Sternalski of 1992 for properly determine a concentration inducing an effect and the consecutive PNEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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