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EC number: 402-920-1 | CAS number: 103300-89-6 N-6-TRIFLUORACETYL-L-LYSYL-L-PROLIN; T.F.A. LYS PRO; TFA-LYS-PRO
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- substances / mixtures which in contact with water emit flammable gases
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-05-13 to 1993-07-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.12 (Flammability (Contact with Water))
- Version / remarks:
- 84/449/EC
- Deviations:
- no
- GLP compliance:
- yes
- Key result
- Test procedure:
- step 1
- step 2
- step 3
- step 4
- Remarks on result:
- no reaction with water observed
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- None of the three tests carried out according to Directive 84/449/EEC, A.12 showed any gas-evolution or ignition of built gas. Therefore the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable in contact of water or damp.
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-05-13 to 1993-07-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.10 (Flammability (Solids))
- Version / remarks:
- 84/449/EEC
- Deviations:
- no
- GLP compliance:
- yes
- Key result
- Test procedure:
- burning rate test over 100 mm length
- Remarks on result:
- substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- There was no measureable burning time in any of the six tests. As defined in Directive 84/449/EEC, A.10 the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable.
Referenceopen allclose all
None of the three tests carried out showed any gas-evolution or ignition of builded gas. Therefore the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable in contact of water or damp.
Result:
At the time the glowing platinum wire was inserted the substance began to burn and melted. But the burning was only in the surroundings of the ignition centre. After a very short time of burning the flame extincted. No spread out of flames.
There was no measureable burning time in any of the six tests. As defined in the EEC-guideline A.10. the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable .
Description of key information
Not highly flammable (EEC method A.10., GLP).
Non highly inflammable in contact of water or damp (EEC method A.12., GLP).
Key value for chemical safety assessment
- Flammability:
- not classified
Additional information
The substance was determined to be not highly flammable in a GLP study conducted according to Directive 84/449/EEC A.10.
The substance was determined to be not highly flammable in contact with water or damp in a GLP study conducted according to Directive 84/449/EEC A.12.
In accordance with Regulation (EC) 1272/2008, Annex I Section 2.10.4.1 "The classification procedure for pyrophoric solids need not be applied when experience in manufacture or handling shows that the substance does not ignite spontaneously on coming into contact with air at normal temperatures (i.e. the substance is known to be stable at room temperature for prolonged periods of time (days))." The substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and therefore a test for "pyrophoric solids" according to Regulation (EC) 440/2008 A.13. does not need to be conducted.
Justification for classification or non-classification
The substance is classified as not highly flammable in accordance with Regulation (EC) No. 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labelling of Chemicals (GHS).
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