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Diss Factsheets
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EC number: 910-853-9 | CAS number: 8011-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with Good laboratory Practice and internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- calcium tetracopper(2+) dioxocopperbis(olate) hexahydroxide sulfate
- EC Number:
- 910-853-9
- Cas Number:
- 8011-63-0
- Molecular formula:
- Ca3Cu4H6O22S4.nH2O where n = 1 to 6
- IUPAC Name:
- calcium tetracopper(2+) dioxocopperbis(olate) hexahydroxide sulfate
- Details on test material:
- - Name of test material (as cited in study report): Bordeaux Mixture
- Composition of test material, percentage of components: 58% w/w as copper
- Lot/batch No.: Not stated
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Young adult males weighing 1.7 to 2.0 kg were housed singly and acclimatised prior to dosing.
Test system
- Type of coverage:
- other: See Details on study design
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 grams.
- Test material was moistened with water prior to administration. - Duration of treatment / exposure:
- Four hours.
- Observation period:
- 72 hours.
- Number of animals:
- Three.
- Details on study design:
- On the day prior to application, an area on the dorsal area of the trunk of each animal was clipped free of fur. The following day, 0.5 g of test material was applied to the intact skin on each rabbit under a gauze patch 2.5 x 2.5 cm in size. The patch was covered with tape and the trunk of the animal was wrapped with an elastic bandage. After 4 hours, the dressings were removed and the skin wiped with dampened tissues to remove any residual test substance. Animals were examined for signs of irritation after 1, 24, 48 and 72 hours and effects scored according to Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- No erythema or oedema was recorded in any animal at any time.
- Other effects:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification according to Directive 67/548/EEC: Not classified.
Classification according to CLP/GHS: Not classified. - Executive summary:
A GLP-compliant study was carried out with Bordeaux Mixture in accordance with the requirements of OECD 404 without significant deviation. Test materialwas moistened with water prior to administration. Three young adult male New Zealand white rabbits weighing 1.7 to 2.0 kg were housed singly and acclimatised prior to dosing. On the day prior to application, an area on the dorsal area of the trunk of each animal was clipped free of fur. The following day, 0.5 g of test material was applied to the intact skin on each rabbit under a gauze patch 2.5 x 2.5 cm in size. The patch was covered with tape and the trunk of the animal was wrapped with an elastic bandage. After 4 hours, the dressings were removed and the skin wiped with dampened tissues to remove any residual test substance. Animals were examined for signs of irritation after 1, 24, 48 and 72 hours and effects scored according to Draize.
No erythema or oedema was recorded in any animal at any time. On this basis, Bordeaux Mixure is not classified as a skin irritant.
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