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Diss Factsheets
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EC number: 233-786-0 | CAS number: 10361-29-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The test system is unsuitable for assessing the carcinogen potential of NaHCO3, as the rats have been pre-treated with BBN.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium hydrogencarbonate
- EC Number:
- 205-633-8
- EC Name:
- Sodium hydrogencarbonate
- Cas Number:
- 144-55-8
- IUPAC Name:
- sodium hydrogen carbonate
- Details on test material:
- - Source: British Drug House, UK.
- Purity: > 99.9%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: TNO Voeding AJ Zeist
- Age: 5 weeks.
- Number of animals: 120 in total, 20 in each of 6 groups.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: feed
- Details on exposure:
- VEHICLE
- Concentration in vehicle: Rats were fed with a control diet (group 1) or diet supplemented with equimolar amounts of the following minerals: 2.34% NaCl (group 2), 2.98% KCl (group 3), 3.36% NaHCO3 (group 4), 1.68% NaHCO3 + 2% KHCO3 (group 5), or 4% KHCO3 (group 6). - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- The rats were pre-exposed to 0.05% N-butyl-N- (4-hydroxybutyl)nitrosamine (BBN) in drinking water for four weeks to initiate tumour formation, and then exposed for 32 weeks.
- Frequency of treatment:
- Continously
- Post exposure period:
- No.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Rats were fed with a control diet (group 1) or diet supplemented with equimolar amounts of the following minerals: 2.34% NaCl (group 2), 2.98% KCl (group 3), 3.36% NaHCO3 (group 4), 1.68% NaHCO3 + 2% KHCO3 (group 5), or 4% KHCO3 (group 6).
Basis:
nominal in diet
- Control animals:
- yes
Examinations
- Observations and examinations performed and frequency:
- CLINICAL OBSERVATIONS AND FREQUENCY
- Body weight: It is reported that is was "measured periodically", with no further details.
- Food consumption: It is reported that is was "measured periodically", with no further details.
- Water consumption: It is reported that is was "measured periodically", with no further details.
- Urinalysis: Performed in week 9, 13, 24, 36. Volume, density, Na, K, Cl, Ca, Mg, P and S were measured. - Sacrifice and pathology:
- ORGANS EXAMINED AT NECROPSY (MACROSCOPIC AND MICROSCOPIC):
- Macroscopic: Urinary bladder.
- Microscopic: Urinary bladder - Statistics:
- Analysis of variance techniques followed by Dunnett's multiple comparison test (body weight) or by the LSD test (food/water intake, urinalyses). Urinary pH values analysed with the Mann/Whitney U-test. Data on microscopical lesions were analyses with the two-sided Fischer exact probability test (incidences) or Student's t-test.
Results and discussion
Results of examinations
- Details on results:
- The incidence of papillary or nodular hyperplasia, papillomas and carcinomas increased in rats fed NaHCO3 only if they had been pretreated with BBN. There was no control group with animals fed NaHCO3 that had not been pretreated with BBN.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.