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Predchádzajúce/výsledok

Predchádzajúce/výsledok

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 
Cobalt hydroxide oxide 234-614-7 12016-80-7
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Cobalt sulphide (EC 215-273-3) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
21/09/2020
05/11/2020
05/11/2020
05/11/2020
Cobalt sulphide 215-273-3 1317-42-6
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study)
21/09/2020
21/09/2020
21/09/2020
05/11/2020
05/11/2020
05/11/2020
Tricobalt tetraoxide 215-157-2 1308-06-1
Sub-chronic toxicity (90 day): inhalation
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Cobalt sulphide (EC 215-273-3) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
21/09/2020
05/11/2020
05/11/2020
05/11/2020
Cobalt 231-158-0 7440-48-4
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
Cobalt bis(2-ethylhexanoate) 205-250-6 136-52-7
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
cobalt di(acetate) 200-755-8 71-48-7
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant
21/09/2020
21/09/2020
05/11/2020
05/11/2020
Cobalt dichloride 231-589-4 7646-79-9
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
Cobalt lithium dioxide 235-362-0 12190-79-3
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with Tricobalt tetraoxide (EC 215-157-2) || Note: Testing proposal is based on concern identified by the registrant.
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
Cobalt oxalate 212-409-3 814-89-1
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
Cobalt(II) 4-oxopent-2-en-2-olate 237-855-6 14024-48-7
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
"Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant. "
21/09/2020
21/09/2020
05/11/2020
05/11/2020
Cobalt, borate propionate complexes 295-033-2 91782-61-5
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
4-(1-oxo-2-propenyl)-morpholine 418-140-1 5117-12-4 Genetic toxicity in vivo 21/09/2020 05/11/2020
Benzenamine, reaction products with aniline hydrochloride and nitrobenzene, hydrochlorides 309-913-1 101357-16-8 Sub-chronic toxicity (90-day): oral 21/09/2020 05/11/2020
Di(tetraethylammonium)hexahydroxoplatinate(IV) 848-537-7 1912392-88-1 Genetic toxicity in vivo 21/09/2020 05/11/2020
Diethylamine 203-716-3 109-89-7 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Dimethylamine (CAS 124-40-3) 21/09/2020 05/11/2020
Fuels, diesel, co-processed with hydrocarbons derived from thermally cracked waste plastics 951-495-3 -
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2)
- Fuels, diesel (EC 269-822-7)
24/08/2020
24/08/2020
08/10/2020
08/10/2020
4-(4-isopropoxyphenylsulfonyl)phenol 405-520-5 95235-30-6 Reproductive toxicity (pre-natal developmental toxicity) 24/08/2020 08/10/2020
Alkanoic acid and polyoxomolybdate borate alkanoate clusters 944-813-7 - Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 24/08/2020 08/10/2020
Bisisopropyl peroxydicarbonate 203-317-4 105-64-6 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 24/08/2020 08/10/2020
Reaction mass of bisisopropyl peroxydicarbonate and bis-sec-butyl peroxydicarbonate and isopropyl-sec-butylperoxydicarbonate 931-536-1 - Genetic toxicity in vivo || Note: testing proposed with bisisopropyl peroxydicarbonate EC 203-317-4, CAS 105-64-6 (is a constituent of the multi-constituent registered substance) || Note: Testing proposal is based on concern identified by the registrant 24/08/2020 08/10/2020
Gas oils (petroleum), light vacuum 265-059-9 64741-58-8
Sub-chronic toxicity (90-day): oral
Sub-chronic toxicity (90 day): dermal
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
07/07/2020
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Condensates (petroleum), vacuum tower 265-049-4 64741-49-7
Sub-chronic toxicity (90 day): dermal || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2)
Genetic toxicity in vivo || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuels, diesel (EC 269-822-7) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2)
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2) - Fuels, diesel (EC 269-822-7)
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Distillates (petroleum), light hydrocracked 265-078-2 64741-77-1
Sub-chronic toxicity (90 day): dermal
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Fuel oil, no. 2 270-671-4 68476-30-2
Sub-chronic toxicity (90 day): dermal || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2)
Genetic toxicity in vivo || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuels, diesel (EC 269-822-7) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2)
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2) - Fuels, diesel (EC 269-822-7)
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Fuel oil, no. 4 270-673-5 68476-31-3
Sub-chronic toxicity (90 day): dermal
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum, (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Fuels, diesel, no. 2 270-676-1 68476-34-6
Sub-chronic toxicity (90 day): dermal || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2)
Genetic toxicity in vivo || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuels, diesel (EC 269-822-7) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2)
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2) - Fuels, diesel (EC 269-822-7)
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Gas oils (petroleum), hydrodesulfurized light vacuum 265-190-1 64742-87-6
Sub-chronic toxicity (90 day): dermal || Note: testing proposed with category members - Gas oils (petroleum), light vacuum (EC 265-059-9) - Fuel oil, no. 4 (EC 270-673-5) - Distillates (petroleum), light hydrocracked (EC 265-078-2)
Genetic toxicity in vivo || Note: testing proposed with category members Gas oils (petroleum), light vacuum (EC 265-059-9), Fuels, diesel (EC 269-822-7), Fuel oil, no. 4 (EC 270-673-5), Distillates (petroleum), light hydrocracked (EC 265-078-2)
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity) 1st (Rat) and 2nd species (Rabbit) (Dermal route) || Note: testing proposed with category members Gas oils (petroleum), light vacuum (EC 265-059-9), Fuels, diesel (EC 269-822-7), Fuel oil, no. 4 (EC 270-673-5), Distillates (petroleum), light hydrocracked (EC 265-078-2)
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Fuels, diesel 269-822-7 68334-30-5
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
Cobalt, borate 2-ethylhexanoate complexes 295-032-7 91782-60-4
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant
07/07/2020
07/07/2020
21/08/2020
21/08/2020
Triethoxyhexadecylsilane 240-465-9 16415-13-7
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Hexadecyltrimethoxysilane (EC 240-464-3) || Note: Testing proposal is based on concern identified by the registrant
07/07/2020
07/07/2020
21/08/2020
21/08/2020
[3-(trimethoxysilyl)propyl]urea 245-904-8 23843-64-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Urea, N-(3-silylpropyl)-, Si-(ethoxy and methoxy) derivs., (EC 601-461-6) || Note: Testing proposal is based on concern identified by the registrant 07/07/2020 21/08/2020
Bis(triethoxysilylpropyl)amine 236-818-1 13497-18-2 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Bis(trimethoxysilylpropyl)amine (EC 403-480-3) || Note: Testing proposal is based on concern identified by the registrant 07/07/2020 21/08/2020
Polyamide wax 434-430-9 - Long-term toxicity to fish 07/07/2020 21/08/2020
4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane 240-212-2 16068-37-4
Long-term toxicity to fish
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant
Reproductive toxicity (pre-natal developmental toxicity)
17/06/2020
17/06/2020
17/06/2020
17/06/2020
03/08/2020
03/08/2020
03/08/2020
03/08/2020
1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane 241-881-3 17955-88-3
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
17/06/2020
17/06/2020
03/08/2020
03/08/2020
4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline) 407-560-9 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
17/06/2020
17/06/2020
03/08/2020
03/08/2020
Bis(trimethoxysilylpropyl)amine 280-084-5 82985-35-1
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity
17/06/2020
17/06/2020
03/08/2020
03/08/2020
dodecamethylpentasiloxane 205-492-2 141-63-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
17/06/2020
17/06/2020
03/08/2020
03/08/2020
2,2'-azobis[4-methoxy-2,4-dimethylvaleronitrile] 239-593-8 15545-97-8 Genetic toxicity in vivo 17/06/2020 03/08/2020
2,6-di-tert-butylphenol 204-884-0 128-39-2 Reproductive toxicity (pre-natal developmental toxicity) 17/06/2020 03/08/2020
3,4-dihydroxybenzonitrile 241-367-9 17345-61-8 Genetic toxicity in vivo 17/06/2020 03/08/2020
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane 219-784-2 2530-83-8 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 17/06/2020 03/08/2020
Barium sulfate 231-784-4 7727-43-7 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Barium chloride (EC 233-788-1) 17/06/2020 03/08/2020
Citronellyl formate 203-338-9 105-85-1 Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant 17/06/2020 03/08/2020
Dimethyl 2,2'-azobis(2-methylpropionate) 219-976-6 2589-57-3 Genetic toxicity in vivo 17/06/2020 03/08/2020
Linalyl acetate 204-116-4 115-95-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 17/06/2020 03/08/2020
Maleic acid 203-742-5 110-16-7 Reproductive toxicity (pre-natal developmental toxicity) 17/06/2020 03/08/2020
N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate 247-161-5 25646-71-3 Genetic toxicity in vivo 17/06/2020 03/08/2020
N-acetylhexanelactam 217-565-6 1888-91-1 Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant 17/06/2020 03/08/2020
Potassium 3-sulphonatopropyl acrylate 250-465-0 31098-20-1 Genetic toxicity in vivo 17/06/2020 03/08/2020
Potassium dicyanoargentate 208-047-0 506-61-6 Genetic toxicity in vivo 17/06/2020 03/08/2020
Potassium dicyanoaurate 237-748-4 13967-50-5 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 17/06/2020 03/08/2020
Reaction mass of 2,4,6,8,10-pentamethyl-2,4,6,8,10-pentavinylcyclopentasiloxane and 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane 911-381-6 - Long-term toxicity to fish || Note: testing proposed with 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (EC 219-863-1) || Note: Testing proposal is based on concern identified by the registrant 17/06/2020 03/08/2020
Reaction mass of disodium (sulphonatothio)acetate and sodium chloride 947-115-0 - Genetic toxicity in vivo 17/06/2020 03/08/2020
1-ethoxy-2-(2-methoxyethoxy)ethane 213-690-5 1002-67-1
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
25/05/2020
09/07/2020
09/07/2020
09/07/2020
1,4-dimethylpiperazine 203-412-0 106-58-1
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
2,2-dimethyl-1,3-dioxolan-4-ylmethanol 202-888-7 100-79-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate 239-701-3 15625-89-5
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
Ashes (residues), nonhazardous municipal solid waste 937-417-0 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer 234-293-3 11071-15-1
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide 435-860-1 214417-91-1
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/05/2020
25/05/2020
09/07/2020
09/07/2020
(3-chloropropyl)dimethoxymethylsilane 242-056-0 18171-19-2 Sub-chronic toxicity (90-day): oral 25/05/2020 09/07/2020
(R)-p-mentha-1,8-diene 227-813-5 5989-27-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/05/2020 09/07/2020
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters 701-339-3 - Reproductive toxicity (pre-natal developmental toxicity) 25/05/2020 09/07/2020
1,3-Propanediamine, N-[3-((C11-14, C13-rich)oxy)propyl]- branched acetate 931-295-2 - Sub-chronic toxicity (90-day): oral 25/05/2020 09/07/2020
1-(4-(ACETYLOXY)-3-((ACETYLOXY)METHYL)PHENYL)ETHANONE 921-042-4 - Genetic toxicity in vivo 25/05/2020 09/07/2020
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (EC 219-137-4) 25/05/2020 09/07/2020
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4 2370-88-9 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/05/2020 09/07/2020
4,4'-isopropylidenedi-o-cresol 201-240-0 79-97-0 Genetic toxicity in vivo 25/05/2020 09/07/2020
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 218-664-7 2212-81-9 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide CAS: 25155-25-3)” 25/05/2020 09/07/2020
Choline hydroxide 204-625-1 123-41-1 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Choline chloride (EC 200-655-4) 25/05/2020 09/07/2020
Dichlorobis(η-cyclopentadienyl)titanium 215-035-9 1271-19-8 Genetic toxicity in vivo 25/05/2020 09/07/2020
Dimethoxymethylsilane 240-914-9 16881-77-9 Sub-chronic toxicity (90-day): oral 25/05/2020 09/07/2020
hexadecyltrimethoxysilane 240-464-3 16415-12-6 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/05/2020 09/07/2020
Lithium phosphorodifluoridate 643-080-8 24389-25-1 Reproductive toxicity (pre-natal developmental toxicity) 25/05/2020 09/07/2020
Lithium tetrafluoroborate, anhydrous 238-178-9 14283-07-9 Genetic toxicity in vivo 25/05/2020 09/07/2020
N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine 264-761-2 64265-45-8 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant. 25/05/2020 09/07/2020
p-tert-butylstyrene 217-126-9 1746-23-2 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. 25/05/2020 09/07/2020
Phosphoric acid, 2-ethylhexyl ester 235-741-0 12645-31-7 Reproductive toxicity (pre-natal developmental toxicity) 25/05/2020 09/07/2020
Platinum(IV) aqua hydroxo nitrato complexes 701-319-4 - Genetic toxicity in vivo 25/05/2020 09/07/2020
Platinum, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane complexes 701-315-2 - Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. 25/05/2020 09/07/2020
Reaction mass of 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane and 4,4,14,14-tetraethoxy-3,15-dioxa-8,9,10-trithia-4,14-disilaheptadecane 915-748-1 - Sub-chronic toxicity (90-day): oral || Note: testing proposed with polysulfides, bis[3-(triethyoxysilyl)propyl (CAS No 211519-85-6) 25/05/2020 09/07/2020
Reaction mass of sodium 1-methoxy-1-oxohexadecane-2-sulphonate and sodium methyl 2-sulphooctadecanoate 911-616-2 - Sub-chronic toxicity (90-day): oral 25/05/2020 09/07/2020
Sodium 1-hydroxyethanesulphonate 213-037-4 918-04-7 Genetic toxicity in vivo 25/05/2020 09/07/2020
triethoxy(methyl)silane 217-983-9 2031-67-6 Sub-chronic toxicity (90-day): oral 25/05/2020 09/07/2020
Zinc bis(benzenesulphinate) 246-148-1 24308-84-7 Genetic toxicity in vivo 25/05/2020 09/07/2020
Distillates (petroleum), hydrodesulfurized middle 265-183-3 64742-80-9 Genetic toxicity in vivo 14/05/2020 29/06/2020
Distillates (petroleum), hydrotreated middle 265-148-2 64742-46-7 Genetic toxicity in vivo 14/05/2020 29/06/2020
Gas oils (petroleum), hydrodesulfurized 265-182-8 64742-79-6 Genetic toxicity in vivo 14/05/2020 29/06/2020
Benzyldimethylamine 203-149-1 103-83-3
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
23/03/2020
07/05/2020
07/05/2020
07/05/2020
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate 255-901-3 42594-17-2
Reproductive toxicity (pre-natal developmental toxicity)
Bioaccumulation test (Bioconcentration: Flow-through Fish Test)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
4-(1,1-dimethylethyl)cyclohexyl acrylate 282-104-8 84100-23-2
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
N,N''-(4-methyl-m-phenylene)bis[N',N'-dimethylurea] 241-523-6 17526-94-2
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid 931-291-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
(Z)-4-[C11-13 (branched) alkylamino]-4-oxo-2-butenoic acid 701-116-0 - Reproductive toxicity (pre-natal developmental toxicity) 23/03/2020 07/05/2020
1,4-bis(2,3-epoxypropoxy)butane 219-371-7 2425-79-8 Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane (1:2) (EC 618-939-5) 23/03/2020 07/05/2020
2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate 224-116-8 4203-89-8 Genetic toxicity in vivo 23/03/2020 07/05/2020
2-[[(butylamino)carbonyl]oxy]ethyl acrylate 264-036-0 63225-53-6 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 23/03/2020 07/05/2020
2-isocyanatoethyl methacrylate 250-284-7 30674-80-7 Reproductive toxicity (pre-natal developmental toxicity) 23/03/2020 07/05/2020
4-phenylbutenone 204-555-1 122-57-6 Genetic toxicity in vivo 23/03/2020 07/05/2020
Dialkyl-methyl-dihydro-heteropolycyle 815-131-6 913171-06-9 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 23/03/2020 07/05/2020
Dimethyl (p-methoxybenzylidene)malonate 231-185-8 7443-25-6 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 23/03/2020 07/05/2020
Dioctyltin dilaurate 222-883-3 3648-18-8 Reproductive toxicity (pre-natal developmental toxicity) 23/03/2020 07/05/2020
Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide 810-703-1 1187441-10-6 Genetic toxicity in vivo 23/03/2020 07/05/2020
tert-butyl perbenzoate 210-382-2 614-45-9 Long-term toxicity to fish 23/03/2020 07/05/2020
(1S)-1,5-anhydro-2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol 695-878-0 1283129-18-9
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
24/02/2020
24/02/2020
09/04/2020
09/04/2020
2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide 686-241-8 81058-27-7
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
24/02/2020
24/02/2020
09/04/2020
09/04/2020
Dibutyl itaconate 218-451-9 2155-60-4
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo
24/02/2020
24/02/2020
09/04/2020
09/04/2020
Etocrilene 226-029-0 5232-99-5
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
24/02/2020
24/02/2020
09/04/2020
09/04/2020
Fluorobenzene 207-321-7 462-06-6
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
24/02/2020
24/02/2020
09/04/2020
09/04/2020
N,N,2,8-tetramethyl-5,11-dioxa-2,8-diazatridecan-13-amine 695-748-3 65286-55-7
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
24/02/2020
24/02/2020
09/04/2020
09/04/2020
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide 806-543-7 215917-77-4
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
24/02/2020
24/02/2020
09/04/2020
09/04/2020
reaction products of benzaldehyde diethylenetriamine and triethylenetetramine, hydrogenated 846-447-2 1219458-07-7
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
24/02/2020
24/02/2020
09/04/2020
09/04/2020
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] 284-366-9 84852-53-9 Reproductive toxicity (extended one-generation reproductive toxicity study) 24/02/2020 09/04/2020
1,4-phenylenebis[(4-phenoxyphenyl)methanone] 620-097-9 54299-17-1 Bioaccumulation test in Fish, Reproductive toxicity (pre-natal developmental toxicity) 24/02/2020 09/04/2020
3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate 261-665-2 59219-71-5 Sub-chronic toxicity (90-day): oral 24/02/2020 09/04/2020
4-tert-butylcyclohexyl acetate 250-954-9 32210-23-4 Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with cis-4-tert-butylcyclohexyl acetate
24/02/2020 09/04/2020
Camphene 201-234-8 79-92-5 Sub-chronic toxicity (90-day): oral 24/02/2020 09/04/2020
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 260-829-0 57583-35-4
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- 500-012-0 9004-77-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1).
Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Reaction products of monoethanolamine and boric acid (1:1) 701-025-6 -
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0)
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Reaction products of monoethanolamine and boric acid (1:3) 701-024-0 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol 264-261-4 63469-23-8
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
12/03/2020
12/03/2020
2,2'-isopropylidenebis(p-phenyleneoxy)diethanol 212-985-6 901-44-0
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
12/03/2020
12/03/2020
3-[[3-[[(2-cyanoethyl)amino]methyl]-3,5,5-trimethylcyclohexyl]amino]propiononitrile 300-496-1 93940-97-7
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
12/03/2020
12/03/2020
Diethyl ethylphosphonate 201-111-9 78-38-6
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
12/03/2020
12/03/2020
N,N'-diphenyl-p-phenylenediamine 200-806-4 74-31-7
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020
27/01/2020
12/03/2020
12/03/2020
Reaction products of orthoboric acid with 2,2'-iminodiethanol (1:1) 701-083-2 -
"Reproductive toxicity (pre-natal developmental toxicity)
“||Note: testing proposed with MEA Polyborate (EC 701-025-6)”
Sub-chronic toxicity (90-day): oral “||Note: testing proposed with MEA Polyborate (EC 701-025-6)”
27/01/2020
27/01/2020
12/03/2020
12/03/2020
Sodium salts of [hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid (4-7 Na:1) 947-369-2 -
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1

|| Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1

|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020
27/01/2020
12/03/2020
12/03/2020
tetrahydro-2-methylfuran 202-507-4 96-47-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
27/01/2020
27/01/2020
12/03/2020
12/03/2020
1-imino-1H-isoindol-3-amine 222-426-8 3468-11-9 Genetic toxicity in vivo 27/01/2020 12/03/2020
2-(2-(2-butoxyethoxy)ethoxy)ethanol 205-592-6 143-22-6 Reproductive toxicity (pre-natal developmental toxicity):
1st PNDT on the registered substance
2nd PNDT with the registered substance
// Note: Testing proposal for an EOGRTS proposed to be conducted with the analogue substance 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1, CAS 112-35-6)
27/01/2020 12/03/2020
4,4'-[(isopropylidene)bis(p-phenyleneoxy)]diphthalic dianhydride 253-781-7 38103-06-9 Sub-chronic toxicity (90-day): oral 27/01/2020 12/03/2020
4,4'-methylenebis[N-sec-butylaniline] 226-122-6 5285-60-9 Bioaccumulation aquatic / sediment 27/01/2020 12/03/2020
4-chloroformylphthalic anhydride 214-874-8 1204-28-0 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020 12/03/2020
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate 220-482-8 2781-11-5 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020 12/03/2020
Ethylenediamine, salt with phosphoric acid 238-914-9 14852-17-6 Reproductive toxicity (extended one-generation reproductive toxicity study) 27/01/2020 12/03/2020
m-phenylene di(acetate) 203-596-2 108-58-7 Genetic toxicity in vivo 27/01/2020 12/03/2020
N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine 264-438-6 63738-22-7 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020 12/03/2020
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol 907-996-4 - Reproductive toxicity (pre-natal developmental toxicity)
1st and 2nd PNDTs: || Note: testing proposed with 2-92-92-butoxyethoxy)ethoxy)ethanol (EC 205-592-6)
27/01/2020 12/03/2020
Tetramethylammonium hydroxide 200-882-9 75-59-2 Sub-chronic toxicity (90-day): oral
// Note: testing proposed with Tetramethylammonium chloride (EC 200-880-8)
|| Note: Link to justification in the registration dossier not given as the information is confidential
27/01/2020 12/03/2020
Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate 950-225-1 -
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8)
17/12/2019
17/12/2019
31/01/2020
31/01/2020
3-[(3-{[(3-acetoxy-2,2-dimethylpropylidene)amino]methyl}-3,5,5-trimethylcyclohexyl)imino]-2,2-dimethylpropyl acetate 805-722-7 1064082-81-0 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 17/12/2019 31/01/2020
isliFe - - Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 17/12/2019 31/01/2020
Sodium hydrogen N-(1-oxotetradecyl)-L-glutamate 253-981-4 38517-37-2 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with L-Glutamic acid, N-coco acyl derivs., disodium salts (CAS number: 68187-30-4; EC number: 269-085-1) || Note: Testing proposal is based on concern identified by the registrant. 17/12/2019 31/01/2020
2,2'-(octylimino)bisethanol 239-555-0 15520-05-5
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/11/2019
25/11/2019
09/01/2020
09/01/2020
2,4,7,9-Tetramethyldec-5-yne-4,7-diol, ethoxylated 500-022-5 9014-85-1 Reproductive toxicity (pre-natal developmental toxicity)

|| Note: testing proposed with 2,4,7,9-Tetramethyl-5-decyne-4,7-diol (CAS number 126-86-3) ||
25/11/2019 09/01/2020
2-hydroxy-3-propyl-2H-furan-5-one 821-451-7 78920-10-2 Genetic toxicity in vivo

|| Note: Testing proposal is based on concern identified by the registrant. ||
25/11/2019 09/01/2020
Heptanal 203-898-4 111-71-7 Reproductive toxicity (extended one-generation reproductive toxicity study)

|| Note: testing proposed with Heptanoic acid (CAS No. 111-14-8)
25/11/2019 09/01/2020
Hexaboron dizinc undecaoxide 235-804-2 12767-90-7 Genetic toxicity in vivo

|| Note: Testing proposal is based on concern identified by the registrant.
25/11/2019 09/01/2020
Reaction mass of ethoxylated (= 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate 939-702-5 - Long-term toxicity to fish 25/11/2019 09/01/2020
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with Propylene oxide and n-butyl glycidyl ether 926-564-6 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/10/2019
21/10/2019
05/12/2019
05/12/2019
2,2-bis[[(1-oxopentyl)oxy]methyl]propane-1,3-diyl divalerate 239-937-7 15834-04-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 21/10/2019 05/12/2019
2-(2-(2-methoxyethoxy)ethoxy)ethanol 203-962-1 112-35-6 Reproductive toxicity (extended one-generation reproductive toxicity study) 21/10/2019 05/12/2019
2-(2-methoxyethoxy)ethanol 203-906-6 111-77-3 Reproductive toxicity (pre-natal developmental toxicity) 21/10/2019 05/12/2019
N,N-bis(2-ethylhexyl)-5-methyl-1H-benzotriazole-1-methylamine, N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-4-methyl-, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-5-methyl-, 1H-Benzotriazole-1-methanamine, N,N-bis(2-ethylhexyl)-6-methyl-(Mixture) 939-700-4 - Sub-chronic toxicity (90-day): oral 21/10/2019 05/12/2019
Reaction mass of 2,2'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxymethylene]}dioxirane and 1,3-bis{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol and 3,3'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxy]}bis(1-{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol) 941-357-0 - Reproductive toxicity (extended one-generation reproductive toxicity study) 21/10/2019 05/12/2019
2,4,7,9-tetramethyl-4,7-decanediol 451-160-7 17913-76-7
Long-term toxicity to fish
"|| Note: testing proposed with 2,4,7,9-tetramethyldec-5-yne-4,7-diol (EC 204-809-1, CAS 126-86-3)
Reproductive toxicity (pre-natal developmental toxicity)
17/09/2019
17/09/2019
01/11/2019
01/11/2019
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with triethylenetetramine 500-290-3 103758-99-2
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5)
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5)
17/09/2019
17/09/2019
01/11/2019
01/11/2019
tetrasodium 7-[(E)-2-[2-(carbamoylamino)-4-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}phenyl]diazen-1-yl]naphthalene-1,3,6-trisulfonate 474-870-9 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
17/09/2019
17/09/2019
01/11/2019
01/11/2019
1-aminopropan-2-ol 201-162-7 78-96-6 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019
2,2'-(cyclohexylimino)bisethanol 224-809-5 4500-29-2 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019
Butanoic acid, 4-amino-4-oxo-2(or 3)-sulfo-,N-(C16-C18 (even numbered), C18 unsaturated alkyl)), disodium salts 939-691-7 - Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019
Hydroxycyclohexyl phenyl ketone 213-426-9 947-19-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 17/09/2019 01/11/2019
Benzene, diethenyl- and Benzene, ethenylethyl- 910-757-7 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/08/2019
16/08/2019
30/09/2019
30/09/2019
N,N'-dimethyldiphenylthiuram disulphide 234-196-6 10591-84-1
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
16/08/2019
16/08/2019
30/09/2019
30/09/2019
Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol 911-819-6 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/08/2019
16/08/2019
30/09/2019
30/09/2019
Sodium diisobutyldithiophosphinate 236-419-2 13360-78-6
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity) with Rat
24/07/2019
24/07/2019
09/09/2019
09/09/2019
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 254-996-9 40601-76-1 Reproductive toxicity (pre-natal developmental toxicity) with Rat 24/07/2019 09/09/2019
4-fluoro-1,3-dioxolan-2-one 483-360-5 114435-02-8 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 24/07/2019 09/09/2019
Bis(2-chloroethyl) 3,3'-[(2,5-dimethyl-p-phenylene)bis[iminocarbonyl(2-hydroxy-1,3-naphthylene)azo]]di-p-toluate 269-507-4 68259-05-2 Sub-chronic toxicity (90 day): inhalation || Note: Testing proposal is based on concern identified by the registrant 24/07/2019 09/09/2019
Heptanoic acid 203-838-7 111-14-8 Reproductive toxicity (extended one-generation reproductive toxicity study) 24/07/2019 09/09/2019
Reaction mass of trans-Cyclohexadecen-8-one, cis-Cyclohexadecen-8-one, trans-Cyclohexadecen-7-one, cis-Cyclohexadecen-7-one 448-300-4 88642-03-9 Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. 24/07/2019 09/09/2019
Sodium dihydrogenorthophosphate 231-449-2 7558-80-7 Sub-chronic toxicity (90-day): oral 24/07/2019 09/09/2019
Sophorolipids: fermentation products of glucose and fatty acids, C18 (unsaturated), glycerol esters with yeast Candida Bombicola, partially hydrolysed 941-809-7 - Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. 24/07/2019 09/09/2019
Fatty acids, C12-14, α-sulfo, disodium salts 942-523-5 -
Long-term toxicity to fish (OECD 212 – Registrant’s preference)
Sub-chronic toxicity (90-day): oral on rodents
Reproductive toxicity (pre-natal developmental toxicity) on rodents
25/06/2019
25/06/2019
25/06/2019
09/08/2019
09/08/2019
09/08/2019
Asphalt 232-490-9 8052-42-4 Reproductive toxicity (extended one-generation reproductive toxicity study)

[note whilst the registrant has selected the drop down of a RaX TPE – it is not a RaX TPE – registered substance is being tested]”
25/06/2019 09/08/2019
Asphalt, oxidized 265-196-4 64742-93-4 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2019 09/08/2019
Benzyltoluene 248-654-8 27776-01-8 Long-term toxicity to fish (OECD 210) 25/06/2019 09/08/2019
Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide 229-782-3 6731-36-8 Bioaccumulation aquatic / sediment 25/06/2019 09/08/2019
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. 276-014-8 71786-60-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2019 09/08/2019
Hexamethyldisiloxane 203-492-7 107-46-0 Reproductive toxicity (pre-natal developmental toxicity) with the rabbit via inhalation 25/06/2019 09/08/2019
pentasodium 5-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}-3-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-4-hydroxynaphthalene-2,7-disulfonate 402-420-3 89157-03-9 Sub-chronic toxicity (90-day): oral 25/06/2019 09/08/2019
Residues (petroleum), thermal cracked vacuum 295-518-9 062-05-0 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Asphalt (CAS 8052-42-4) 25/06/2019 09/08/2019
Residues (petroleum), vacuum 265-057-8 64741-56-6 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2019 09/08/2019
Strontium oxide 215-219-9 1314-11-0 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2019 09/08/2019
Triisotridecyl phosphite 278-758-9 77745-66-5 Sub-chronic toxicity (90-day): oral 25/06/2019 09/08/2019
Reaction mass of Octadecanamide, 12-hydroxy-N-[2-[(1-oxodecyl)amino]ethyl]- and N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) and Decanamide, N,N'-1,2-ethanediylbis- 907-495-0 -
Reproductive toxicity (pre-natal developmental toxicity): in rat and rabbit
Sub-chronic toxicity (90 day): inhalation
Reproductive toxicity (extended one-generation reproductive toxicity study)
27/05/2019
27/05/2019
27/05/2019
11/07/2019
11/07/2019
11/07/2019
Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts 601-601-6 119345-04-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit
27/05/2019
27/05/2019
11/07/2019
11/07/2019
Lithium bis(oxalato)borate 456-990-3 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/05/2019
27/05/2019
11/07/2019
11/07/2019
Methylphosphonic acid 213-607-2 993-13-5
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4)
27/05/2019
27/05/2019
11/07/2019
11/07/2019
tri{[(2s)-1-ethoxy-1-oxopropan-2-yl]oxy}(vinyl)silane 701-301-6 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/05/2019
27/05/2019
11/07/2019
11/07/2019
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 246-678-3 25155-25-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 27/05/2019 11/07/2019
Alcohols, C11-14-iso-, C13-rich 271-235-6 68526-86-3 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate 401-100-0 - Sub-chronic toxicity (90-day): oral 27/05/2019 11/07/2019
Furan-2,5-dicarboxylic acid 221-800-8 3238-40-2 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
Hexanal 200-624-5 66-25-1 Genetic toxicity in vivo “|| Note: Testing proposal is based on concern identified by the registrant.” 27/05/2019 11/07/2019
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- 911-490-9 - Sub-chronic toxicity (90-day): oral 27/05/2019 11/07/2019
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol 907-996-4 - Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) 27/05/2019 11/07/2019



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