Preskoč na obsah
Preskoč na obsah

Predchádzajúce/výsledok

Predchádzajúce/výsledok

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 
4,4'-methylenebis[2,6-diethylaniline] 237-185-4 13680-35-8
Genetic toxicity in vivo
Long-term toxicity to fish
26/03/2018
26/03/2018
11/05/2018
11/05/2018
(3-chloropropyl)diethoxymethylsilane 236-828-6 13501-76-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with (3-chloropropyl)triethoxysilane (CAS 5089-70-3) 17/04/2015 04/06/2015
2,2'-azobis[2-methylbutyronitrile] 236-740-8 13472-08-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
03/03/2014
17/04/2014
17/04/2014
17/04/2014
(octadecanoato-O)oxoaluminium 236-521-7 13419-15-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7) 30/11/2015 14/01/2016
tetradecahydro-7-isopropyl-1,4a-dimethylphenanthren-1-methanol 236-476-3 13393-93-6
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
Sodium diisobutyldithiophosphinate 236-419-2 13360-78-6
Reproductive toxicity (pre-natal developmental toxicity) with Rat
Sub-chronic toxicity (90-day): oral
24/07/2019
24/07/2019
09/09/2019
09/09/2019
N-octadecylstearamide 236-276-6 13276-08-9
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
17/04/2015
17/04/2015
17/04/2015
04/06/2015
04/06/2015
04/06/2015
N-vinylformamide 236-102-9 13162-05-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/11/2015 16/12/2015
N-vinylformamide 236-102-9 13162-05-5
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/07/2011
01/07/2011
15/08/2011
15/08/2011
tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
15/04/2011
30/05/2011
30/05/2011
30/05/2011
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate) 235-935-5 13052-09-0 Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates 12/12/2014 26/01/2015
Phosphoric acid, butyl ester 235-826-2 12788-93-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/04/2015
17/04/2015
04/06/2015
04/06/2015
Hexaboron dizinc undecaoxide 235-804-2 12767-90-7 Genetic toxicity in vivo

|| Note: Testing proposal is based on concern identified by the registrant.
25/11/2019 09/01/2020
Hexaboron dizinc undecaoxide 235-804-2 12767-90-7
Carcinogenicity study
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
29/04/2011
29/04/2011
29/04/2011
29/04/2011
14/06/2011
14/06/2011
14/06/2011
14/06/2011
barium titanium trioxide 234-975-0 12047-27-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
17/04/2015
17/04/2015
04/06/2015
04/06/2015
praseodymium(III,IV) oxide 234-857-9 12037-29-5 Genetic toxicity in vivo 18/09/2014 03/11/2014
Cobalt hydroxide oxide 234-614-7 12016-80-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Zinc bis[bis(tetrapropylenephenyl)] bis(hydrogen dithiophosphate) 234-277-6 11059-65-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
N,N'-dimethyldiphenylthiuram disulphide 234-196-6 10591-84-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2019
16/08/2019
30/09/2019
30/09/2019
2-aminoethanol, monoester with boric acid 233-829-3 10377-81-8
Long-term or reproductive toxicity to birds
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/07/2011
01/07/2011
01/07/2011
15/08/2011
15/08/2011
15/08/2011
2-aminoethanol, monoester with boric acid 233-829-3 10377-81-8 Sub-chronic toxicity (90-day): oral 17/11/2011 02/01/2012
Bismuth trinitrate 233-791-8 10361-44-1
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8)
20/09/2013
20/09/2013
04/11/2013
04/11/2013
Barium chloride 233-788-1 10361-37-2
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
29/04/2011
29/04/2011
29/04/2011
14/06/2011
14/06/2011
14/06/2011
Barium chloride 233-788-1 10361-37-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
Cobalt (II) dinitrate 233-402-1 10141-05-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Cobalt (II) sulphate 233-334-2 10124-43-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity) ; after obtaining results of the 90-day subchronic toxicity study
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
cerium trinitrate 233-297-2 10108-73-3 Reproductive toxicity (pre-natal developmental toxicity) 17/04/2015 04/06/2015
Sodium permanganate 233-251-1 10101-50-5 Reproductive toxicity (pre-natal developmental toxicity) 15/04/2011 30/05/2011
a,a-dimethylphenethyl butyrate 233-221-8 10094-34-5
Reproductive toxicity (pre-natal developmental toxicity)“|| Note: testing proposed 1,1-Dimethyl-2-phenylethyl acetate (EC 205-781-3)”
Sub-chronic toxicity (90-day): oral“|| Note: testing proposed 1,1-Dimethyl-2-phenylethyl acetate (EC 205-781-3)”
22/11/2017
22/11/2017
08/01/2018
08/01/2018
4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline 233-215-5 10081-67-1 Sub-chronic toxicity (90-day): oral 18/02/2014 04/04/2014
Strontium nitrate 233-131-9 10042-76-9
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
31/05/2011
31/05/2011
31/05/2011
15/07/2011
15/07/2011
15/07/2011
Dipotassium tetrachloroplatinate 233-050-9 10025-99-7 Genetic toxicity in vivo || Note: "Testing proposal is based on concern identified by the registrant." 18/06/2018 02/08/2018
Resin acids and Rosin acids, calcium salts 232-694-8 9007-13-0 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Resin acids and Rosin acids, calcium salts 232-694-8 9007-13-0
Reproductive toxicity (pre-natal developmental toxicity || Note: Testing proposed with Rosin CAS 8050-09-7
Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposed with Rosin CAS 8050-09-7
Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin CAS 8050-09-7, Rosin hydrogenated CAS 65997-06-0, and Rosin reaction products with formaldehyde CAS 91081-53-7
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Asphalt 232-490-9 8052-42-4 Reproductive toxicity (extended one-generation reproductive toxicity study)

[note whilst the registrant has selected the drop down of a RaX TPE – it is not a RaX TPE – registered substance is being tested]”
25/06/2019 09/08/2019
ASPHALT 232-490-9 8052-42-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
31/05/2016
31/05/2016
15/07/2016
15/07/2016
Resin acids and Rosin acids, esters with glycerol 232-482-5 8050-31-5 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Resin acids and Rosin acids, esters with glycerol 232-482-5 8050-31-5
Reproductive toxicity (pre-natal developmental toxicity)|| Note: Testing proposed to be carried out with Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7), Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Rosin, maleated 232-480-4 8050-28-0 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Rosin, maleated 232-480-4 8050-28-0
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0)
Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin, Fumarated (CAS RN 65997-04-7)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and the registered substance
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Resin acids and Rosin acids, esters with pentaerythritol 232-479-9 8050-26-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (pre-natal developmental toxicity)|| Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)
06/03/2012
02/07/2013
02/07/2013
02/07/2013
20/04/2012
16/08/2013
16/08/2013
16/08/2013
Resin acids and Rosin acids, esters with triethylene glycol 232-478-3 8050-25-7
Reproductive toxicity (pre-natal developmental toxicity) //Note: Testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Resin acids and Rosin acids, esters with triethylene glycol 232-478-3 8050-25-7 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Resin acids and Rosin acids, hydrogenated, Me esters 232-476-2 8050-15-5 Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7) 02/07/2013 16/08/2013
Rosin 232-475-7 8050-09-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral || Note: Testing proposed with rosin CAS 8050-09-7; Rosin, hydrogenated (CAS RN 65997-06-0), Rosin, reaction products with formaldehyde (CAS RN 91081-53-7)
06/03/2012
02/07/2013
02/07/2013
02/07/2013
20/04/2012
16/08/2013
16/08/2013
16/08/2013
Alcohols, lanolin 232-430-1 8027-33-6
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Cashew, nutshell liq. 232-355-4 8007-24-7
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
31/10/2011
Terpineol 232-268-1 8000-41-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
Terpineol 232-268-1 8000-41-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/07/2011
01/07/2011
15/08/2011
15/08/2011
Strontium chromate 232-142-6 7789-06-2 Long-term toxicity to fish 31/05/2011 15/07/2011
dichloro(3-chloropropyl)methylsilane 232-136-3 7787-93-1 Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with (3-chloropropyl)triethoxysilane (EC 225-805-6, CAS 5089-70-3) 16/10/2014 01/12/2014
(-)-pin-2(3)-ene 232-077-3 7785-26-4 Reproductive toxicity (pre-natal developmental toxicity) 25/10/2017 11/12/2017
Multi-Wall Carbon Nanotubes, synthetic graphite in tubular shape 231-955-3 7782-42-5 Long-term toxicity to fish 03/11/2011 19/12/2011
Silver nitrate 231-853-9 7761-88-8 Sub-chronic toxicity (90-day): oral 16/06/2011 01/08/2011
Pentasodium triphosphate 231-838-7 7758-29-4 Sub-chronic toxicity (90-day) via the inhalatory route (rat) 08/04/2010 24/05/2010
Barium sulfate 231-784-4 7727-43-7 Long-term toxicity to fish 29/04/2011 14/06/2011
Potassium permanganate 231-760-3 7722-64-7 Reproductive toxicity (two-generation reproductive toxicity) 14/02/2011 31/03/2011
N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine 231-701-1 7691-02-3
Reproductive toxicity (pre-natal developmental toxicity) “|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)”
Sub-chronic toxicity (90 day): inhalation “|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)”
12/12/2014
12/12/2014
26/01/2015
26/01/2015
Sodium phosphinate 231-669-9 7681-53-0 Reproductive toxicity (developmental toxicity) 26/01/2011 14/03/2011
Cobalt dichloride 231-589-4 7646-79-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
cobalt dichloride 231-589-4 7646-79-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/07/2016
18/07/2016
01/09/2016
01/09/2016


Boron trifluoride 231-569-5 - Genetic toxicity in vivo 01/07/2011 15/08/2011
Pentaerythritol tetrakis(3-mercaptopropionate) 231-472-8 7575-23-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
01/07/2011
01/07/2011
01/07/2011
15/08/2011
15/08/2011
15/08/2011
Sodium dihydrogenorthophosphate 231-449-2 7558-80-7 Sub-chronic toxicity (90-day): oral 24/07/2019 09/09/2019
Sodium dihydrogenorthophosphate 231-449-2 7558-80-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2016 17/10/2016
4-methylmorpholine 4-oxide, monohydrate 231-391-8 7529-22-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/02/2015
16/02/2015
16/02/2015
02/04/2015
02/04/2015
02/04/2015
2-hydroxy-2-methylpropiophenone 231-272-0 7473-98-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day)
21/10/2019
15/03/2011
15/03/2011
15/03/2011
05/12/2019
29/04/2011
29/04/2011
29/04/2011
Lithium chloride 231-212-3 7447-41-8 Reproductive toxicity (two-generation reproductive toxicity) 29/04/2011 14/06/2011
tellurium dioxide 231-193-1 7446-07-3 Sub-chronic toxicity (90-day): oral 16/03/2015 30/04/2015
Bismuth 231-177-4 7440-69-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
30/05/2011
30/05/2011
Cobalt 231-158-0 7440-48-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Silver 231-131-3 7440-22-4 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with silver(1+) acetate (CAS number 563-63-3) 27/09/2017 13/11/2017
Silver 231-131-3 7440-22-4 Sub-chronic toxicity (90-day): oral 29/04/2011 14/06/2011
Silicon 231-130-8 7440-21-3 Subchronic toxicity (90 day): inhalation 14/02/2011 31/03/2011
Nickel 231-111-4 7440-02-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2019 15/04/2019
Butyl glycollate 230-991-7 7397-62-8 Sub-chronic toxicity (90-day): oral 15/04/2011 30/05/2011
Aluminum triformate 230-898-1 7360-53-4
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity study (90-day): oral
21/01/2011
21/01/2011
21/01/2011
07/03/2011
07/03/2011
07/03/2011
tetrapotassium pyrophosphate 230-785-7 7320-34-5 Sub-chronic toxicity (90 day): inhalation 01/07/2011 15/08/2011
Bis(2,3-epoxypropyl) terephthalate 230-565-0 7195-44-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2012
16/05/2012
16/05/2012
02/07/2012
02/07/2012
02/07/2012
2-(dimethylamino)-2-methylpropan-1-ol 230-279-6 7005-47-2 Reproductive toxicity (pre-natal developmental toxicity) 31/01/2014 17/03/2014
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) 230-257-6 6990-43-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate 229-934-9 6846-50-0 Reproductive toxicity (pre-natal developmental toxicity) 14/03/2016 28/04/2016
dimethoxydiphenylsilane 229-929-1 6843-66-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide 229-782-3 6731-36-8 Reproductive toxicity (pre-natal developmental toxicity) 01/07/2011 15/08/2011
Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide 229-782-3 6731-36-8 Bioaccumulation aquatic / sediment 25/06/2019 09/08/2019
1,8-diazabicyclo[5.4.0]undec-7-ene 229-713-7 6674-22-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
4-methylthiosemicarbazide 229-563-2 6610-29-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
03/11/2014
03/11/2014
3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane 229-542-8 6600-31-3 Reproductive toxicity (pre-natal developmental toxicity) 15/07/2014 29/08/2014
1,1`-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene 228-846-8 6362-80-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Sodium hydrogen-5-sulphoisophthalate 228-845-2 6362-79-4 Genetic toxicity in vivo 29/04/2014 13/06/2014
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9)
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9)
04/10/2013
04/10/2013
18/11/2013
18/11/2013
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4)
31/01/2018
31/01/2018
19/03/2018
19/03/2018


trichloro(hexadecyl)silane 227-575-2 5894-60-0
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
Sub-chronic toxicity (90-day): oral
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
N,N'-hexane-1,6-diylbis(hexahydro-2-oxo-1H-azepine-1-carboxamide) 227-563-7 5888-87-9 Genetic toxicity in vivo 18/09/2014 03/11/2014
1,1,3,3-tetramethylbutyl hydroperoxide 227-369-2 5809-08-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
dichlorocyclohexylmethylsilane 226-956-0 5578-42-7 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [dicyclopentyldimethoxysilane] (CAS 126990-35-0) 16/03/2015 30/04/2015
2-ethylhexyl benzoate 226-641-8 5444-75-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
02/06/2014
17/07/2014
17/07/2014
17/07/2014
Guanidinium phosphate (1:1) 226-551-9 5423-22-3 Sub-chronic toxicity (90-day): oral 16/05/2014 30/06/2014
Citral 226-394-6 5392-40-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018
Pentane-1,2-diol 226-285-3 5343-92-0 Sub-chronic toxicity (90-day): oral 16/06/2011 01/08/2011
2-Octyldodecan-1-ol 226-242-9 5333-42-6 Reproductive toxicity (two-generation reproductive toxicity) 05/04/2011 20/05/2011
Sulphamidic acid 226-218-8 5329-14-6 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with ammonium sulphamate (pH consideration) 23/04/2018 07/06/2018
Sulphamidic acid 226-218-8 5329-14-6
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
14/02/2011
14/02/2011
14/02/2011
31/03/2011
31/03/2011
31/03/2011
octyltrichlorosilane 226-112-1 5283-66-9 Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) 25/06/2015 10/08/2015
N-[3-(dimethylamino)propyl]methacrylamide 226-002-3 5205-93-6 Reproductive toxicity (pre-natal developmental toxicity) 29/04/2011 14/06/2011
5-ethyl-1,3-dioxane-5-methanol 225-967-8 5187-23-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2014
31/01/2014
17/03/2014
17/03/2014
N-isopropylhydroxylamine 225-791-1 5080-22-8
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 225-716-2 5026-74-4
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 225-716-2 5026-74-4
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
N-(3-aminopropyl)iminodiethanol 225-642-0 4985-85-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
2,2-bis(hydroxymethyl)propionic acid // 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid 225-306-3 -
Reproductive toxicity (pre-natal developmental toxicity study)
Sub-chronic oral toxicity (90-day): oral
05/04/2011
05/04/2011
20/05/2011
20/05/2011
Octylphosphonic acid 225-218-5 4724-48-5 Reproductive toxicity (pre-natal developmental toxicity) 16/05/2014 30/06/2014
2,2'-(cyclohexylimino)bisethanol 224-809-5 4500-29-2 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019
4-morpholinecarbaldehyde 224-518-3 4394-85-8 Sub-chronic toxicity (90-day): oral 04/04/2014 19/05/2014
2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) 02/11/2018 17/12/2018
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) 224-235-5 4259-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
methylsilanetriyl triacetate 224-221-9 4253-34-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [Trimethoxy(methyl)silane] (EC 214-685-0) 16/03/2015 30/04/2015
2,2-dimethylpropane-1,3-diyl dibenzoate 224-081-9 4196-89-8 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016
Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate 223-989-2 4156-21-2 Sub-chronic toxicity (90-day): oral 29/04/2014 13/06/2014
3,6,9,12-tetraazatetradecamethylenediamine 223-775-9 4067-16-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with structural analogues TETA (CAS 90640-67-8) and HEPA (CAS 68121-73-7).
Reproductive toxicity (pre-natal developmental toxicity)
22/11/2017
22/11/2017
08/01/2018
08/01/2018
3,6,9,12-tetraazatetradecamethylenediamine 223-775-9 4067-16-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
28/02/2011
28/02/2011
14/04/2011
14/04/2011
Nonane-1,9-diol 223-517-5 3937-56-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
05/07/2018
05/07/2018
20/08/2018
20/08/2018
Sodium chloroacetate 223-498-3 3926-62-3 Reproductive toxicity (two-generation reproductive toxicity) 16/06/2011 01/08/2011
Sodium chloroacetate 223-498-3 3926-62-3 Reproductive toxicity (pre-natal developmental toxicity) 14/10/2011 28/11/2011
Bumetrizole 223-445-4 3896-11-5 Bioaccumulation aquatic / sediment 18/06/2018 02/08/2018
bis(3,5,5-trimethylhexanoyl) peroxide 223-356-0 3851-87-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
Octa-1,7-diene 223-054-9 3710-30-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
N-butylbenzenesulphonamide 222-823-6 3622-84-2 Reproductive toxicity (pre-natal developmental toxicity) 14/02/2011 31/03/2011
N-butylbenzenesulphonamide 222-823-6 3622-84-2 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016
tert-butyl α,α-dimethylbenzyl peroxide 222-389-8 3457-61-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
tert-butyl α,α-dimethylbenzyl peroxide 222-389-8 3457-61-2 Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates 16/03/2015 30/04/2015
Icos-1-ene 222-374-6 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/09/2011
15/09/2011
31/10/2011
31/10/2011
1-(2-hydroxyethyl)pyrrolidin-2-one 222-359-4 3445-11-2 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
Bisisobutyryl peroxide 222-340-0 3437-84-1
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
04/04/2014
04/04/2014
04/04/2014
19/05/2014
19/05/2014
19/05/2014
tert-pentyl hydroperoxide 222-321-7 3425-61-4 Genetic toxicity in vivo 21/03/2014 05/05/2014
tert-pentyl hydroperoxide 222-321-7 3425-61-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
07/10/2016
07/10/2016
21/11/2016
21/11/2016
sodium O,O-diethyl dithiophosphate || Note: testing proposed with sodium O,O-diisobutyl dithiophosphate (EC 258-508-5) 222-079-2 3338-24-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
03/11/2014
03/11/2014
3,5,5-trimethylhexanoic acid 221-975-0 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
15/07/2011
15/07/2011
Propylidynetrimethyl trimethacrylate 221-950-4 3290-92-4 Reproductive toxicity (pre-natal developmental toxicity) 31/05/2016 15/07/2016
Propylidynetrimethyl trimethacrylate 221-950-4 3290-92-4 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/04/2019 10/06/2019
1,1,3,3-tetramethyldisiloxane 221-906-4 3277-26-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
29/04/2016
29/04/2016
13/06/2016
13/06/2016
Furan-2,5-dicarboxylic acid 221-800-8 3238-40-2 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol 221-573-5 3147-75-9 Bioaccumulation aquatic / sediment 15/07/2014 29/08/2014
2-methoxyethyl acrylate 221-499-3 3121-61-7 Genetic toxicity in vivo 21/03/2014 05/05/2014
p-tert-butylphenyl 1-(2,3-epoxy)propyl ether 221-453-2 3101-60-8
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
17/06/2014
17/06/2014
17/06/2014
17/06/2014
01/08/2014
01/08/2014
01/08/2014
01/08/2014
trimethoxyoctylsilane 221-338-7 3069-40-7 Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (CAS 35435-21-3) 07/08/2015 22/09/2015
Trimethoxyoctylsilane 221-338-7 3069-40-7
Reproductive toxicity (extended one-generation reproductive toxicity study || Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with triethoxyoctylsilane (CAS 2943-75-1)
27/09/2017
27/09/2017
13/11/2017
13/11/2017
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine 221-336-6 3069-29-2
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.
Sub-chronic toxicity (90-day): oral
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Tetra(isobutyl)thioperoxydicarbamic acid 221-312-5 3064-73-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/06/2018
18/06/2018
02/08/2018
02/08/2018
3-ethyloxetane-3-methanol 221-254-0 3047-32-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2014
31/01/2014
17/03/2014
17/03/2014
hex-3-yne-2,5-diol 221-209-5 3031-66-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
03/11/2014
03/11/2014
bis(2-dimethylaminoethyl)(methyl)amine 221-201-1 3030-47-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
Cyclohexylidenebis[tert-butyl] peroxide 221-111-2 3006-86-8 Sub-chronic toxicity (90-day): oral 21/03/2014 05/05/2014
tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
15/04/2011
30/05/2011
30/05/2011
30/05/2011
2,2'-azobis[2-methylpropionamidine] dihydrochloride 221-070-0 2997-92-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
05/07/2018
05/07/2018
20/08/2018
20/08/2018
Trimethoxyphenylsilane 221-066-9 2996-92-1 Reproductive toxicity (pre-natal developmental toxicity) 03/03/2014 17/04/2014
Triethoxyoctylsilane 220-941-2 2943-75-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
Triethoxyoctylsilane 220-941-2 2943-75-1 Long-term toxicity to fish || Note: testing proposed with Triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1) 17/04/2015 04/06/2015
[3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane 220-780-8 2897-60-1 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 16/12/2016 30/01/2017
2,2,6,6-tetramethyl-4-oxopiperidinooxy 220-778-7 2896-70-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2)
14/08/2014
14/08/2014
28/09/2014
28/09/2014
N-(1,1-dimethyl-3-oxobutyl)acrylamide 220-713-2 2873-97-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
N-ethyl-2-pyrrolidone (NEP) 220-250-6 2687-91-4
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day) via the inhalatory route
26/01/2011
26/01/2011
14/03/2011
14/03/2011
1,1,3,3-tetramethyl-1,3-divinyldisiloxane 220-099-6 2627-95-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane 219-863-1 2554-06-5
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
03/03/2014
03/03/2014
03/03/2014
03/03/2014
17/04/2014
17/04/2014
17/04/2014
17/04/2014
4-phenylbutan-2-one 219-847-4 2550-26-7 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a read-across substance having similar formula structure and its carbon chain consists of even number of carbons 22/11/2017 08/01/2018
Triethoxypropylsilane 219-842-7 2550-02-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
03/03/2014
03/03/2014
17/04/2014
17/04/2014
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0 Reproductive toxicity (pre-natal developmental toxicity) 26/04/2019 10/06/2019
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
01/09/2017
01/09/2017
16/10/2017
16/10/2017
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): inhalation
15/04/2011
15/04/2011
30/05/2011
30/05/2011
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane 219-784-2 2530-83-8 Genetic toxicity in vivo 16/02/2015 02/04/2015
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane 219-784-2 2530-83-8 Genetic toxicity in vivo 01/08/2012 17/09/2012
3-(trimethoxysilyl)propiononitrile 219-764-3 2526-62-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/03/2014
21/03/2014
05/05/2014
05/05/2014
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) 219-514-3 2451-62-9 Reproductive toxicity (two-generation reproductive toxicity) 19/11/2010 03/01/2011
2-(2H-benzotriazol-2-yl)-p-cresol 219-470-5 2440-22-4 Bioaccumulation aquatic / sediment 18/06/2018 02/08/2018
11-aminoundecanoic acid 219-417-6 2432-99-7 Reproductive toxicity (developmental toxicity) 08/04/2010 24/05/2010
1,4-bis(2,3-epoxypropoxy)butane 219-371-7 2425-79-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): most appropriate route
14/02/2011
14/02/2011
14/02/2011
31/03/2011
31/03/2011
31/03/2011
2-Hexyldecan-1-ol 219-370-1 2425-77-6 Reproductive toxicity (two-generation reproductive toxicity) 05/04/2011 20/05/2011
Benzophenone-3,3':4,4'-tetracarboxylic dianhydride 219-348-1 2421-28-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4 2370-88-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4 2370-88-9
Sub-chronic toxicity (90-day): oral
-
22/11/2017
22/11/2017
08/01/2018
08/01/2017
N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide 218-915-0 2280-49-1
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2014
18/02/2014
04/04/2014
04/04/2014
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl 218-760-9 2226-96-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl 218-760-9 2226-96-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/02/2015
16/02/2015
02/04/2015
02/04/2015
butan-2-one O,O',O''-(vinylsilylidyne)trioxime 218-747-8 2224-33-1 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Butan-2-one O,O',O''-(methylsilylidyne)trioxime (CAS 22984-54-9).
25/06/2015 10/08/2015
Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) 218-679-9 2215-35-2
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 218-664-7 2212-81-9
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant
20/10/2016
20/10/2016
05/12/2016
05/12/2016
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 218-664-7 2212-81-9
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2012
16/05/2012
16/05/2012
02/07/2012
02/07/2012
02/07/2012
2,3-epoxypropyl o-tolyl ether 218-645-3 2210-79-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
Vinyl laurate 218-414-7 2146-71-6 Sub-chronic toxicity (90-day): oral 16/05/2011 30/06/2011
triethoxy(methyl)silane 217-983-9 2031-67-6 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with trimethoxy(methyl)silane. 16/10/2014 01/12/2014
1,1'-(1,1,2,2-tetramethylethylene)dibenzene 217-568-2 1889-67-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
6-tert-butyl-2,4-xylenol 217-533-1 1879-09-0 Long-term toxicity to fish 15/07/2014 29/08/2014
1,1,1,3,5,5,5-heptamethyltrisiloxane 217-496-1 1873-88-7
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7
Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7.
25/06/2015
25/06/2015
10/08/2015
10/08/2015
2-ethyl-N,N-bis(2-ethylhexyl)hexylamine 217-461-0 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/01/2012
16/01/2012
01/03/2012
01/03/2012
Octabenzone 217-421-2 1843-05-6 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2013 04/04/2013
N-(3-(trimethoxysilyl)propyl)ethylenediamine 217-164-6 1760-24-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
Aminoiminomethanesulphinic acid 217-157-8 1758-73-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/05/2014
16/05/2014
30/06/2014
30/06/2014
chlorodimethylvinylsilane 217-007-1 1719-58-0 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Trimethylsilanol (CAS 1066-40-6) 12/12/2014 26/01/2015
Strontium carbonate 216-643-7 1633-05-2 Long-term toxicity to fish 31/05/2011 15/07/2011
Cobalt(2+) propionate 216-333-1 1560-69-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011



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