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Predchádzajúce/výsledok

Predchádzajúce/výsledok

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 
6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one 403-830-5 89331-94-2
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
23/04/2018
23/04/2018
23/04/2018
07/06/2018
07/06/2018
07/06/2018
6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one 403-830-5 89331-94-2 Sub-chronic toxicity (90-day): oral 02/09/2013 18/10/2013
6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one 403-830-5 89331-94-2 Sub-chronic toxicity (90-day): oral 26/03/2018 11/05/2018
6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one 403-830-5 89331-94-2 Bioaccumulation aquatic / sediment 12/06/2015 27/07/2015
O,O-di(1-methylethyl)trithio-bis-thioformate,O,O-di(1-methylethyl)tetrathio-bis-thioformate,O,O-di(1-methylethyl)pentathio-bis-thioformate 403-030-6 - Reproductive toxicity (pre-natal developmental toxicity) 24/05/2013 08/07/2013
pentasodium 5-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}-3-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-4-hydroxynaphthalene-2,7-disulfonate 402-420-3 89157-03-9 Sub-chronic toxicity (90-day): oral 25/06/2019 09/08/2019
Cyclohexyldimethoxymethylsilane 402-140-1 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/01/2012
16/01/2012
16/01/2012
01/03/2012
01/03/2012
01/03/2012
3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione 401-540-3 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/03/2018
26/03/2018
26/03/2018
11/05/2018
11/05/2018
11/05/2018
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate 401-100-0 - Sub-chronic toxicity (90-day): oral 27/05/2019 11/07/2019
A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene),α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene) 400-830-7 - Reproductive toxicity (pre-natal developmental toxicity) 16/12/2011 30/01/2012
Tris(2,5,8,11-tetraoxatridecyl) orthoborate 310-290-3 161907-80-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Tar, brown-coal, low-temp. 309-886-6 101316-84-1 Sub-chronic toxicity (90-day): oral 29/07/2011 12/09/2011
Residues (petroleum), vacuum distn. residue hydrogenation 309-713-4 100684-40-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Residues (petroleum), distn. residue hydrogenation 309-712-9 100684-39-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Octadecanoic acid, 12-hydroxy-, reaction products with ethylenediamine 309-629-8 100545-48-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
16/05/2014
16/05/2014
30/06/2014
30/06/2014
d-Glucose, ether with glycerol 309-496-6 100402-60-6 Reproductive toxicity (pre-natal developmental toxicity) 15/07/2014 29/08/2014
Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction 308-482-7 98072-31-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 02/11/2018 17/12/2018
Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction 308-482-7 98072-31-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/08/2011
01/08/2011
15/09/2011
15/09/2011
Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs. 308-208-6 97925-95-6 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed on rabbits 14/08/2014 28/09/2014
Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs. 308-208-6 97925-95-6
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
29/07/2011
29/07/2011
12/09/2011
12/09/2011
2-Propanol, 1,1'-[[3-[(3-aminopropyl)amino]propyl]imino]bis-, N-tallow alkyl derivs 307-276-4 97592-79-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Resin acids and Rosin acids, fumarated, esters with glycerol 307-051-0 97489-11-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6)
19/07/2013
19/07/2013
02/09/2013
02/09/2013
Rosin, fumarated, reaction products with formaldehyde 305-795-0 95009-65-7 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Rosin, fumarated, reaction products with formaldehyde 305-795-0 95009-65-7
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0).
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0)
02/07/2013
02/07/2013
16/08/2013
16/08/2013
Resin acids and Rosin acids, maleated, esters with pentaerythritol 305-516-2 94581-17-6
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7)
Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6)
19/07/2013
19/07/2013
02/09/2013
02/09/2013
Resin acids and Rosin acids, fumarated, esters with pentaerythritol 305-514-1 94581-15-4 Reproductive toxicity (pre-natal developmental toxicity) 16/07/2012 30/08/2012
Resin acids and Rosin acids, fumarated, esters with pentaerythritol 305-514-1 94581-15-4
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7)
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7)
Reproductive toxicity (two-generation reproductive toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6)
Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6)
19/07/2013
02/07/2013
02/07/2013
19/07/2013
19/07/2013
02/07/2013
02/09/2013
16/08/2013
16/08/2013
02/09/2013
02/09/2013
16/08/2013
Sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate 305-318-6 94441-92-6 Reproductive toxicity (pre-natal developmental toxicity) 02/06/2014 17/07/2014
Aluminum, benzoate C16-18-fatty acids complexes 303-385-6 94166-87-7 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015
Boric acid (H3BO3), reaction products with ethanolamine 302-207-4 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/01/2012
16/01/2012
16/01/2012
01/03/2012
01/03/2012
01/03/2012
Gas oils, paraffinic 300-227-8 93924-33-5 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011
Alkenes, C24-28 α- 300-203-7 93924-11-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
25/06/2012
15/07/2011
15/07/2011
09/08/2012
Alkenes, C20-24 α- 300-202-1 93924-10-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
25/06/2012
15/07/2011
15/07/2011
09/08/2012
tripotassium propylsilanetriolate 299-135-8 93857-00-2
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with [trimethoxypropylsilane] (EC 213-926-7)
Sub-chronic toxicity (90 day): inhalation Note: testing proposed with [trimethoxypropylsilane] (EC 213-926-7)
16/03/2015
16/03/2015
30/04/2015
30/04/2015
Zinc bis[O-(6-methylheptyl)] bis[O-(sec-butyl)] bis(dithiophosphate) 298-577-9 93819-94-4
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Alkenes, C15-18 297-797-2 93762-80-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
25/06/2012
30/09/2011
30/09/2011
09/08/2012
Phosphorous acid, tri-C12-14-alkyl esters 297-701-9 93686-48-7
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
16/02/2015
16/02/2015
02/04/2015
02/04/2015
Hydrocarbons, C4, 1,3-butadiene-free, polymd., triisobutylene fraction, hydrogenated 297-629-8 93685-81-5 Reproductive toxicity (two-generation reproductive toxicity) 25/06/2012 09/08/2012
Hydrocarbons, C4, 1,3-butadiene-free, polymd., tetraisobutylene fraction, hydrogenated 297-628-2 - Reproductive toxicity (two-generation reproductive toxicity) 25/06/2012 09/08/2012
Ashes (residues), plant 297-049-5 93333-79-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2011
16/05/2011
16/05/2011
30/06/2011
30/06/2011
30/06/2011
Ashes (residues), plant 297-049-5 93333-79-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
31/01/2018
31/01/2018
19/03/2018
19/03/2018
Rosin, fumarated, reaction products with glycerol and pentaerythritol 296-047-1 92202-14-7
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7)
Reproductive toxicity (two-generation reproductive toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS 94581-15-4)
Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS 97489-11-7); Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS 94581-15-4); and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS 94581-17-6)
19/07/2013
19/07/2013
02/07/2013
19/07/2013
02/07/2013
02/09/2013
02/09/2013
16/08/2013
02/09/2013
16/08/2013
Rosin, fumarated, reaction products with glycerol and pentaerythritol 296-047-1 92202-14-7 Reproductive toxicity (pre-natal developmental toxicity) 16/07/2012 30/08/2012
Resin acids and Rosin acids, reaction products with formaldehyde, potassium salt 295-855-1 92129-53-8 Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin (CAS RN 8050-09-7), Rosin, hydrogenated (CAS RN 65997-06-0), and Rosin, reaction products with formaldehyde (CAS RN 91081-53-7) 02/07/2013 16/08/2013
Fatty acids, tall-oil, compds. with N-[3-(dimethylamino)propyl]tall-oil amides 295-714-4 92128-22-8 Reproductive toxicity (pre-natal developmental toxicity) 28/02/2018 16/04/2018
dihydro-3-(tripropenyl)furan-2,5-dione 295-556-6 92077-08-2 Reproductive toxicity (pre-natal developmental toxicity) 30/09/2015 16/11/2015
Residues (petroleum), thermal cracked vacuum 295-518-9 062-05-0 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Asphalt (CAS 8052-42-4) 25/06/2019 09/08/2019
Residues (petroleum), thermal cracked vacuum 295-518-9 92062-05-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Gas oils (petroleum), hydrotreated light vacuum 295-407-5 92045-24-4 Reproductive toxicity (two-generation reproductive toxicity) 15/07/2011 29/08/2011
Extracts (petroleum), deasphalted vacuum residue solvent 295-332-8 91995-70-9 Reproductive toxicity (two-generation reproductive toxicity) 29/07/2011 12/09/2011
Extracts (petroleum), deasphalted vacuum residue solvent 295-332-8 91995-70-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Resin acids and Rosin acids, maleated, calcium salts 294-402-5 91722-01-9
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0)
02/07/2013
02/07/2013
16/08/2013
16/08/2013
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-C12-14 acyl derivs., hydroxides, inner salts 293-878-1 91648-19-0
Long-term toxicity to fish || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-457-4)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3)
18/06/2018
18/06/2018
18/06/2018
02/08/2018
02/08/2018
02/08/2018
Rosin, reaction products with formaldehyde 293-659-0 91081-53-7
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Rosin (CAS RN 8050-09-7)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with _ Rosin (CAS RN 8050-09-7)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin (CAS RN 8050-09-7), Rosin, hydrogenated (CAS RN 65997-06-0), Rosin, reaction products with formaldehyde (CAS RN 91081-53-7)
19/07/2013
02/07/2013
02/07/2013
02/09/2013
16/08/2013
16/08/2013
Rosin, reaction products with formaldehyde 293-659-0 91081-53-7 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Fatty acids, C16-18, reaction products with diethanolamine 293-014-3 91032-08-5 Reproductive toxicity (pre-natal developmental toxicity) 16/03/2015 30/04/2015
Fatty acids, C16-18, barium salts 292-883-6 91002-07-2 Long-term toxicity to fish //Note: testing to be done with barium dichloride (CAS number 10361-37-2) 04/04/2014 19/05/2014
Amines, polyethylenepoly-, triethylenetetramine fraction 292-588-2 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/11/2017
22/11/2017
08/01/2018
08/01/2018


Amines, polyethylenepoly-, triethylenetetramine fraction,Triethylenetetramine linear, cyclic and branched 292-588-2 90640-66-7 Reproductive toxicity (two-generation reproductive toxicity) 05/04/2011 20/05/2011
Amines, polyethylenepoly-, triethylenetetramine fraction,Triethylenetetramine linear, cyclic and branched 292-588-2 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/09/2017
01/09/2017
16/10/2017
16/10/2017
Amines, polyethylenepoly-, tetraethylenepentamine fraction 292-587-7 90640-66-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/11/2015 16/12/2015
Amines, polyethylenepoly-, tetraethylenepentamine fraction 292-587-7 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with TETA (CAS 90640-67-8) and HEPA (68121-73-7)
Reproductive toxicity (pre-natal developmental toxicity )
31/01/2018
31/01/2018
19/03/2018
19/03/2018
Alkanes, C12-26-branched and linear 292-454-3 90622-53-0 Reproductive toxicity (two-generation reproductive toxicity) 15/09/2011 31/10/2011
Alkenes, C13-14, hydroformylation products, distn. residues 292-429-7 90622-29-0 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Alkenes, C11-12, hydroformylation products, distn. residues (EC 292-427-6) 02/11/2018 17/12/2018
Alkenes, C13-14, hydroformylation products, distn. Residues 292-429-7 90622-29-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Alkenes, C11-12, hydroformylation products, distn. residues 292-427-6 90622-27-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Alkenes, C11-12, hydroformylation products, distn. Residues 292-427-6 90622-27-8 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018
Hydrochloric acid, reaction products with aniline and nitrobenzene, sulfonated, sodium salts 291-454-0 90411-76-0 Reproductive toxicity (pre-natal developmental toxicity) 30/11/2015 14/01/2016
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters 290-754-9 90218-76-1 Sub-chronic toxicity (90-day): oral 29/07/2011 12/09/2011
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts 288-917-4 85940-28-9
"Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) ""Testing proposed according to a plan for the ZDDP category.“ "
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Fatty acids, tall-oil, compds. with oleylamine 288-315-1 85711-55-3 Long-term toxicity to fish 04/04/2014 19/05/2014
Alkenes, C10-14 288-213-7 85681-75-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
25/06/2012
31/10/2011
31/10/2011
09/08/2012
Alkenes, C10-13 287-479-1 85535-87-1
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/09/2011
15/09/2011
31/10/2011
31/10/2011
Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins) 287-476-5 85535-84-8 Reproductive toxicity (two-generation reproductive toxicity) 29/07/2011 12/09/2011
2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt 286-344-4 85209-91-2
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/10/2014
16/10/2014
16/10/2014
01/12/2014
01/12/2014
01/12/2014
2-Butenedioic acid (Z)-, ester with 1,2-propanediol, compd. with 2-(dibutylamino)ethanol 286-304-6 85204-10-0
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
02/06/2014
02/06/2014
17/07/2014
17/07/2014
17/07/2014
17/07/2014
2-ethylhexanoic acid, monoester with propane-1,2-diol 285-503-5 85114-00-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
Fatty acids, C16-18 and C18-unsatd., Et esters 285-206-0 85049-36-1 Long-term toxicity to fish 01/07/2011 15/08/2011
Phosphoric acid, mixed esters with Bu alc. and ethylene glycol 284-716-0 84962-20-9
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1
20/05/2015
20/05/2015
06/07/2015
06/07/2015
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts 283-392-8 84605-29-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
2-Butenoic acid, 4-oxo-4-(tridecylamino)-, (Z)-, branched 283-219-6 84583-68-6 Sub-chronic toxicity (90-day): oral 12/04/2017 29/05/2017
Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate 282-810-6 84434-11-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
30/06/2014
30/06/2014
Formaldehyde, reaction products with ethylenediamine 281-928-5 84066-92-2 Genetic toxicity in vivo 16/05/2014 30/06/2014
Benzoic acid, 2-hydroxy-, mono-C>13-alkyl derivs., calcium salts (2:1) 281-018-8 83846-43-9 Sub-chronic toxicity (90-day): oral 18/06/2018 02/08/2018
Bis(2,4,4-trimethylpentyl)phosphinic acid 280-445-7 83411-71-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/04/2014
29/04/2014
13/06/2014
13/06/2014
Sulfonium compounds, C11-14-alkylbis(hydroxyethyl), 2-hydroxyethyl sulfates (salts) 278-855-6 78169-20-7 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2014 04/04/2014
Triisotridecyl phosphite 278-758-9 77745-66-5 Sub-chronic toxicity (90-day): oral 25/06/2019 09/08/2019
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide 278-355-8 75980-60-8 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2014 04/04/2014
Disodium oxybis[methylbenzenesulphonate] 277-242-0 73037-34-0 Reproductive toxicity (pre-natal developmental toxicity) 17/06/2014 01/08/2014
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione 276-763-0 72676-55-2 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 20/10/2016 05/12/2016
6-[(1-oxomethyloctyl)amino]hexanoic acid 276-173-3 71902-23-3 Reproductive toxicity (pre-natal developmental toxicity) 10/03/2017 25/04/2017
Quaternary ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl, chlorides 276-038-9 71808-53-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. 276-014-8 71786-60-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2019 09/08/2019
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. 276-014-8 71786-60-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): oral
14/08/2014
14/08/2014
14/08/2014
28/09/2014
28/09/2014
28/09/2014
m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 275-662-9 71604-74-5
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
O-(2-ethylhexyl) O,O-tert-pentyl peroxycarbonate 274-919-2 70833-40-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol 274-570-6 70321-86-7 Bioaccumulation aquatic / sediment 15/07/2014 29/08/2014
Slags, silicomanganese-manufg. 273-733-9 69012-33-5 Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Slags, ferromanganese-manufg. CAS No 69012-28-8 (EC No 273-728-1) 25/10/2017 11/12/2017
Slags, phosphorus-manufg. 273-732-3 69012-32-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
01/07/2011
01/07/2011
01/07/2011
15/08/2011
15/08/2011
15/08/2011
Slags, ferromanganese-manufg. 273-728-1 69012-28-8 Reproductive toxicity (pre-natal developmental toxicity) 26/03/2018 11/05/2018
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts 273-527-9 68988-45-4
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
19/11/2018
19/11/2018
Octene, hydroformylation products, low-boiling 273-110-1 68938-03-4 Genetic toxicity in vivo 17/06/2014 01/08/2014
Polysulfides, di-tert-Bu 273-103-3 68937-96-2 Bioaccumulation aquatic / sediment 01/07/2011 15/08/2011
Phenol, isopropylated, phosphate (3:1) 273-066-3 68937-41-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
Phenol, isopropylated, phosphate (3:1) 273-066-3 68937-41-7
Bioaccumulation aquatic / sediment
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
29/07/2011
29/07/2011
29/07/2011
12/09/2011
12/09/2011
12/09/2011
12/09/2011
12/09/2011
Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene 272-940-1 68921-45-9
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the smallest aryl- and alkyl-substituted materials
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the smallest aryl- and alkyl-substituted materials
14/08/2014
14/08/2014
28/09/2014
28/09/2014
Fatty acids, tall-oil, reaction products with 2-[(2-aminoethyl)amino]ethanol 272-902-4 68919-76-6 Reproductive toxicity (pre-natal developmental toxicity) 10/03/2017 25/04/2017
Fatty acids, tall-oil, reaction products with 2-[(2-aminoethyl)amino]ethanol 272-902-4 68919-76-6 Sub-chronic toxicity (90 day): oral 16/05/2014 30/06/2014
Gas oils (petroleum), straight-run, high-boiling 272-818-8 68915-97-9 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011
Distillates (petroleum), heavy straight-run 272-817-2 68915-96-8 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011
Fatty acids, tall-oil, reaction products with formaldehyde and (Z)-N-9-octadecenyl-1,3-propanediamine 272-789-1 68911-83-1 Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposal is based on concern identified by the registrant. 15/07/2014 29/08/2014
Hydrocarbons, C12-30, olefin-rich, ethylene polymn. by-product 272-762-4 68911-05-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
25/06/2012
30/09/2011
30/09/2011
09/08/2012
Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides, reaction products with polyethylenepolyamines and tall-oil fatty acids, humates hydrochlorides 272-745-1 68910-55-4
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
23/01/2015
23/01/2015
23/01/2015
23/01/2015
09/03/2015
09/03/2015
09/03/2015
09/03/2015
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts 272-723-1 68909-93-3
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Allyl (cyclohexyloxy)acetate 272-657-3 68901-15-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/08/2018
10/08/2018
24/09/2018
24/09/2018
Kieselguhr, soda ash flux-calcined 272-489-0 68855-54-9 Sub-chronic toxicity (90 day): inhalation 01/07/2011 15/08/2011
Distillates (petroleum), full-range straight-run middle 272-341-5 68814-87-9 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts 272-238-5 68784-31-6
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (pre-natal developmental toxicity) 29/07/2011 12/09/2011
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (two-generation reproductive toxicity) 02/02/2012 19/03/2012
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018
Linseed oil, oxidized 272-038-8 68649-95-6 Genetic toxicity in vivo 01/07/2011 15/08/2011
Resin acids and Rosin acids, hydrogenated, esters with triethylene glycol 271-996-4 68648-53-3
Reproductive toxicity (pre-natal developmental toxicity)|| Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)
02/07/2013
02/07/2013
16/08/2013
16/08/2013
9-Octadecenoic acid (Z)-, sulfonated, potassium salts 271-843-1 68609-93-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/02/2015
16/02/2015
16/02/2015
02/04/2015
02/04/2015
02/04/2015
1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. residues 271-832-1 68609-68-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. residues 271-832-1 68609-68-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide 271-794-6 68608-66-2 Long-term toxicity to fish 18/02/2014 04/04/2014
Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide 271-794-6 68608-66-2 Long-term toxicity to fish Sub-chronic toxicity (90-day): oral || Note: testing proposed with Reaction products of 1H-Imidazole- 1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid (EC 931-291-0) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid (EC 931-291-0 29/02/2016 14/04/2016
Alkanes, C10-13-iso- 271-366-9 68551-17-7 Reproductive toxicity (two-generation reproductive toxicity) 25/06/2012 09/08/2012
Dodecene, hydroformylation products, low-boiling 271-240-3 68526-92-1 Sub-chronic toxicity (90-day): oral 29/04/2014 13/06/2014
Dodecene, hydroformylation products, low-boiling 271-240-3 68526-92-1 Reproductive toxicity (pre-natal developmental toxicity) 01/09/2017 16/10/2017
Dodecene, hydroformylation products, high boiling 271-239-8 68526-91-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
Octene, hydroformylation products, high-boiling 271-237-7 68526-89-6 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018
Octene, hydroformylation products, high-boiling 271-237-7 68526-89-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
Alcohols, C11-14-iso-, C13-rich 271-235-6 68526-86-3 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
ALCOHOLS, C11-14-ISO-, C13-RICH 271-235-6 68526-86-3 Sub-chronic toxicity (90-day): oral 31/05/2016 15/07/2016
ALCOHOLS, C7-9-ISO-, C8-RICH 271-231-4 68526-83-0 Sub-chronic toxicity (90-day): oral 31/05/2016 15/07/2016
Alkenes, C8-10, C9-rich 271-212-0 68526-55-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
25/06/2012
12/09/2011
12/09/2011
09/08/2012
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters 271-082-5 68515-40-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/06/2011
16/06/2011
01/08/2011
01/08/2011
Resin acids and Rosin acids, esters with ethylene glycol 270-986-7 68512-65-2 Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, ethylene glycol ester (CAS RN 68512-65-2) 02/07/2013 16/08/2013
Phenol, methylstyrenated 270-966-8 68512-30-1
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
29/07/2011
29/07/2011
12/09/2011
12/09/2011
Diethylmethylbenzenediamine 270-877-4 68479-98-1 Reproductive toxicity (pre-natal developmental toxicity) 29/07/2011 12/09/2011
Fuels, diesel, no. 2 270-676-1 68476-34-6 Reproductive toxicity (two-generation reproductive toxicity) 15/07/2011 29/08/2011
Fuel oil, no. 4 270-673-5 68476-31-3 Reproductive toxicity (two-generation reproductive toxicity) 16/08/2011 30/09/2011
Fuel oil, no. 2 270-671-4 68476-30-2 Reproductive toxicity (two-generation reproductive toxicity) 15/07/2011 29/08/2011
Flue dust, portland cement 270-659-9 68475-76-3
Genetic toxicity in vivo
Sub-chronic toxicity (90 day): inhalation
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts 270-608-0 68457-79-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
01/09/2016
01/09/2016
01/09/2016
17/10/2016
17/10/2016
17/10/2016
Cobalt, borate neodecanoate complexes 270-601-2 68457-13-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu) esters, zinc salts 270-478-5 68442-22-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Resin acids and Rosin acids, magnesium salts 270-461-2 68440-56-2 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Resin acids and Rosin acids, magnesium salts 270-461-2 68440-56-2
Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Rosin (CAS 8050-09-7)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Rosin (CAS 8050-09-7)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin (CAS 8050-09-7); Rosin, hydrogenated (CAS 65997-06-0); and Rosin, reaction products with formaldehyde (CAS 91081-53-7)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Polysulfides, di-tert-nonyl 270-336-2 68425-16-1 Sub-chronic toxicity (90-day): oral 06/09/2018 22/10/2018
Polysulfides, di-tert-dodecyl 270-335-7 68425-15-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2018
31/01/2018
31/01/2018
19/03/2018
19/03/2018
19/03/2018
Polysulfides, di-tert-dodecyl 270-335-7 68425-15-0 Bioaccumulation aquatic / sediment 01/07/2011 15/08/2011
Polysulfides, di-tert-dodecyl 270-335-7 68425-15-0 Bioaccumulation aquatic / sediment 16/02/2015 02/04/2015
Fatty acids, lanolin 270-302-7 68424-43-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene 270-128-1 68411-46-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/10/2017 11/12/2017
Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene 270-128-1 68411-46-1
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity study (90-day): oral
05/04/2011
05/04/2011
20/05/2011
20/05/2011
Pyridine, alkyl derivs. 269-929-9 68391-11-7 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 5-ethyl-2-methylpyridine 04/04/2014 19/05/2014
Resin acids and Rosin acids, calcium zinc salts 269-825-3 68334-35-0 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Resin acids and Rosin acids, calcium zinc salts 269-825-3 68334-35-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with Rosin (CAS 8050-09-7)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Rosin (CAS 8050-09-7)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin (CAS 8050-09-7); Rosin, hydrogenated (CAS 65997-06-0); and Rosin, reaction products with formaldehyde (CAS 91081-53-7)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Fuels, diesel 269-822-7 68334-30-5 Reproductive toxicity (two-generation reproductive toxicity) 16/08/2011 30/09/2011
Shale oils 269-646-0 68308-34-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
17/11/2011
17/11/2011
17/11/2011
02/01/2012
02/01/2012
02/01/2012
Shale oils 269-646-0 68308-34-9 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Shale oils, heavy fractions (Registration No 01-2119756217-35-0000)” Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with Shale oils, heavy fractions (Registration No 01-2119756217-35-0000)” 14/03/2016 28/04/2016
Bis(2-chloroethyl) 3,3'-[(2,5-dimethyl-p-phenylene)bis[iminocarbonyl(2-hydroxy-1,3-naphthylene)azo]]di-p-toluate 269-507-4 68259-05-2 Sub-chronic toxicity (90 day): inhalation || Note: Testing proposal is based on concern identified by the registrant 24/07/2019 09/09/2019
Resin acids and Rosin acids, maleated, sodium salts 269-228-8 68201-60-5
Reproductive toxicity (pre-natal developmental toxicity) //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0)
Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin, Fumarated (CAS RN 65997-04-7)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
l-Glutamic acid, N-coco acyl derivs., disodium salts 269-085-1 68187-30-4 Reproductive toxicity (pre-natal developmental toxicity) 18/09/2014 03/11/2014
Resin acids and Rosin acids, Me esters 269-035-9 68186-14-1
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1)
02/07/2013
02/07/2013
16/08/2013
16/08/2013
Resin acids and Rosin acids, esters with diethylene glycol 268-884-2 68153-38-8
Reproductive toxicity (pre-natal developmental toxicity), || Note: testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7)
02/07/2013
02/07/2013
16/08/2013
16/08/2013
Tall oil, maleated 268-859-6 68152-93-2
Bioaccumulation aquatic / sediment
Long-term toxicity to fish
04/10/2018
04/10/2018
19/11/2018
19/11/2018
Amines, tallow alkyl, dodecylbenzenesulfonates 268-766-0 68139-94-6
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/11/2015
30/11/2015
30/11/2015
14/01/2016
14/01/2016
14/01/2016
Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) 268-717-3 68133-90-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 04/10/2018 19/11/2018
Amines, polyethylenepoly- 268-626-9 68131-73-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 22/11/2017 08/01/2018
Amines, polyethylenepoly- 268-626-9 68131-73-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
Amines, polyethylenepoly- 268-626-9 68131-73-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
28/02/2011
28/02/2011
14/04/2011
14/04/2011
Polyphosphoric acids, esters with triethanolamine, sodium salts 268-625-3 68131-72-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
15/04/2014
15/04/2014
30/05/2014
30/05/2014
Sulfite liquors and Cooking liquors, green 268-612-2 68131-30-6 Genetic toxicity in vivo 31/05/2011 15/07/2011
Naphthenic acids, reaction products with diethylenetriamine 268-610-1 68131-13-5 Reproductive toxicity (pre-natal developmental toxicity) 18/09/2014 03/11/2014
Amines, C16-22-alkyl 268-215-4 68037-92-3 Reproductive toxicity (pre-natal developmental toxicity) 16/05/2014 30/06/2014
orthoboric acid, compound with 2,2'-iminodiethanol 267-886-0 67952-33-4
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with MEA Polyborate
Sub-chronic toxicity (90-day): oral || Note: testing proposed with MEA Polyborate
30/11/2015
30/11/2015
14/01/2016
14/01/2016
Fatty acids, tall-oil, reaction products with triethanolamine 267-053-1 67784-78-5
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
29/07/2011
29/07/2011
12/09/2011
12/09/2011
12/09/2011
12/09/2011
2-[methyl[(nonafluorobutyl)sulphonyl]amino]ethyl acrylate 266-733-5 67584-55-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
1-[bis[3-(dimethylamino)propyl]amino]propan-2-ol 266-587-2 67151-63-7 Sub-chronic toxicity (90-day): oral 21/03/2014 05/05/2014
(5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014
Resin acids and Rosin acids, hydrogenated, esters with glycerol 266-042-9 65997-13-9
Reproductive toxicity (pre-natal developmental toxicity) //Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Resin acids and Rosin acids, hydrogenated, esters with glycerol 266-042-9 65997-13-9 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Rosin, hydrogenated 266-041-3 65997-06-0 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Rosin, hydrogenated 266-041-3 65997-06-0
Reproductive toxicity (pre-natal developmental toxicity) //Note: Testing proposed with Rosin (CAS RN 8050-09-7)
Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin (CAS RN 8050-09-7)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin (CAS RN 8050-09-7), Rosin, hydrogenated (CAS RN 65997-06-0), and Rosin, reaction products with formaldehyde (CAS RN 91081-53-7)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Rosin, fumarated 266-040-8 65997-04-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0)
Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with the registered substance (CAS RN 65997-04-7)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0)
06/03/2012
02/07/2013
02/07/2013
02/07/2013
20/04/2012
16/08/2013
16/08/2013
16/08/2013
Slimes and Sludges, blast furnace and steelmaking 266-006-2 65996-73-8
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Dust, steelmaking 266-005-7 65996-72-7 Reproductive toxicity (pre-natal developmental toxicity) 01/07/2011 15/08/2011
[4-[p,p'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium m-[[p-anilinophenyl]azo]benzenesulphonate 265-449-9 65113-55-5
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
04/04/2014
Paraffins (petroleum), normal C>10 265-232-9 64771-71-7 Reproductive toxicity (two-generation reproductive toxicity) 15/09/2011 31/10/2011
Asphalt, oxidized 265-196-4 64742-93-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
18/02/2013
18/02/2013
04/04/2013
04/04/2013
Asphalt, oxidized 265-196-4 64742-93-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Asphalt, oxidized 265-196-4 64742-93-4 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2019 09/08/2019
Gas oils (petroleum), hydrodesulfurized light vacuum 265-190-1 64742-87-6 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011
Residues (petroleum), hydrodesulfurized vacuum 265-188-0 64742-85-4
Reproductive toxicity (pre-natal developmental toxicity) || Note: test proposed with a liquid condensate collected from the headspace of a heated tank of Residues (petroleum), thermal cracked vacuum (CAS No 92062-05-0)
Reproductive toxicity (two-generation reproductive toxicity) || Note: test proposed with a liquid condensate collected from the headspace of a heated tank of Residues (petroleum), thermal cracked vacuum (CAS No 92062-05-0)
04/04/2014
04/04/2014
19/05/2014
19/05/2014
Distillates (petroleum), hydrodesulfurized middle 265-183-3 64742-80-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Distillates (petroleum), hydrodesulfurized middle 265-183-3 64742-80-9 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011



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