Predchádzajúce/výsledok
Predchádzajúce/výsledok
Predchádzajúce/výsledok
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
5-Methoxy-2-tetralone | 457-080-9 | - | Genetic toxicity in vivo | 06/09/2018 | 22/10/2018 | Details | |
Polysulfides, di-tert-nonyl | 270-336-2 | 68425-16-1 | Sub-chronic toxicity (90-day): oral | 06/09/2018 | 22/10/2018 | Details | |
Soybean oil, oligomerized | 701-252-0 | - | Reproductive toxicity (pre-natal developmental toxicity) | 06/09/2018 | 22/10/2018 | Details | |
Reaction mass of 2-ethyl-2-(methoxymethyl)-propane-1,3-diol and 2-ethylpropane-1,3-diol | 938-572-7 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
06/09/2018 06/09/2018 |
22/10/2018 22/10/2018 |
Details | |
Pleuromulin | 204-747-5 | 125-65-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
06/09/2018 06/09/2018 06/09/2018 |
22/10/2018 22/10/2018 22/10/2018 |
Details | |
C14-16 (even numbered) and C16 (branched) saturated and unsaturated aliphatic hydrocarbons | 700-762-0 | - |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with an analogue substance. Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with an analogue substance. Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with an analogue substance. |
01/10/2018 01/10/2018 01/10/2018 |
15/11/2018 15/11/2018 15/11/2018 |
Details | |
Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) | 268-717-3 | 68133-90-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 04/10/2018 | 19/11/2018 | Details | |
N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide; N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide | 700-208-8 | - | Sub-chronic toxicity (90-day): oral | 04/10/2018 | 19/11/2018 | Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts | 273-527-9 | 68988-45-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
Tall oil, maleated | 268-859-6 | 68152-93-2 |
Bioaccumulation aquatic / sediment Long-term toxicity to fish |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
Zinc bis[bis(dodecylphenyl)] bis(dithiophosphate) | 259-048-8 | 54261-67-5 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
|
Details |
Zinc bis[O-(2-ethylhexyl)] bis[O-(isobutyl)] bis(dithiophosphate) | 247-810-2 | 26566-95-0 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts | 283-392-8 | 84605-29-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts | 288-917-4 | 85940-28-9 |
"Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) ""Testing proposed according to a plan for the ZDDP category.“
" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu) esters, zinc salts | 270-478-5 | 68442-22-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts | 272-723-1 | 68909-93-3 |
Sub-chronic toxicity (90-day): oral || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts | 272-238-5 | 68784-31-6 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Zinc bis(O,O-diisooctyl) bis(dithiophosphate) | 249-109-7 | 28629-66-5 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Zinc bis[bis(tetrapropylenephenyl)] bis(hydrogen dithiophosphate) | 234-277-6 | 11059-65-7 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) | 224-235-5 | 4259-15-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Zinc bis[O-(6-methylheptyl)] bis[O-(sec-butyl)] bis(dithiophosphate) | 298-577-9 | 93819-94-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) | 230-257-6 | 6990-43-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) | 218-679-9 | 2215-35-2 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category. |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
1-Dodecene, dimers | 814-509-8 | 62132-67-6 | Reproductive toxicity (pre-natal developmental toxicity) | 02/11/2018 | 17/12/2018 | Details | |
2,2,4,4,6,8,8-heptamethylnonane | 224-506-8 | 4390-04-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) | 02/11/2018 | 17/12/2018 | Details | |
Alkane-alpha,omega-diyl bis{[(trimethoxysilyl)propyl]carbamate}_M2 | 700-904-1 | 1350725-68-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methyl [3-(trimethoxysilyl) propyl]carbamate CAS 23432-62-4 | 02/11/2018 | 17/12/2018 | Details | |
Alkenes, C13-14, hydroformylation products, distn. residues | 292-429-7 | 90622-29-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Alkenes, C11-12, hydroformylation products, distn. residues (EC 292-427-6) | 02/11/2018 | 17/12/2018 | Details | |
Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction | 308-482-7 | 98072-31-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 02/11/2018 | 17/12/2018 | Details | |
Diethyl ether | 200-467-2 | 60-29-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 02/11/2018 | 17/12/2018 | Details | |
Hydrocarbons, C14-C16, n-alkanes, <2% aromatics | 921-535-4 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 02/11/2018 | 17/12/2018 | Details | |
Hydrocarbons, C14-C17, n-alkanes, <2% aromatics | 917-828-1 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a group: Icosane (EC 204-018-1) and Hydrocarbons, C14-C19, isoalkanes, cyclics, < 2% aromatics (920-114-2) | 02/11/2018 | 17/12/2018 | Details | |
Fatty acids, C12-14, α-sulfo, disodium salts | 942-523-5 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
02/11/2018 02/11/2018 |
17/12/2018 17/12/2018 |
Details | |
Propionaldehyde, reaction product with formaldehyde | 701-281-9 | - | Genetic toxicity in vivo || Note: the EC/list number of the substance has been changed. | 10/12/2018 | 24/01/2019 | Details | |
1,4-Cyclohexanedicarboxylic acid, 1,4-diisononyl ester | 701-012-5 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 |
Details | |
4-oxovaleric acid | 204-649-2 | 123-76-2 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 |
Details | |
benzyl butyl cis-cyclohexane-1,2-dicarboxylate | 701-279-8 | 1931129-39-3 |
Long-term toxicity to fish || Note: Link to the registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5 Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5 Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5 |
10/12/2018 10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 24/01/2019 |
Details | |
hexamolybdenum(3+) tris((dioctylcarbamothioyl)sulfanide) tris((ditridecylcarbamothioyl)sulfanide) hexahydrate hexasulfanediide | 441-570-4 | - |
Bioaccumulation aquatic / sediment || Note: Link to registration dossier not given as the dossier not yet disseminated. Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated. Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated. |
10/12/2018 10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 24/01/2019 |
Details | |
1,3,2-dioxathiolane 2,2-dioxide | 600-809-4 | 1072-53-3 | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine | 628-863-4 | 1219458-14-6 | Reproductive toxicity (pre-natal developmental toxicity) | 24/01/2019 | 11/03/2019 | Details | |
Reaction mass of N,N,N',N'-tetrabutylmethylenediamine and dibutylamine | 948-040-6 | - | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
Reaction products of acrylic acid with 2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] | 830-217-3 | 1393932-71-2 |
Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated |
24/01/2019 24/01/2019 |
11/03/2019 11/03/2019 |
Details | |
3a,4,7,7a-tetrahydro-4,7-methanoindene | 201-052-9 | 77-73-6 | Reproductive toxicity (pre-natal developmental toxicity) | 28/02/2019 | 15/04/2019 | Details | |
Hydrocarbons, C16-C18, isoalkanes,<2% aromatics | 948-766-3 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2019 | 15/04/2019 | Details | |
Nickel | 231-111-4 | 7440-02-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2019 | 15/04/2019 | Details | |
Distillates (petroleum), hydrodesulfurized middle | 265-183-3 | 64742-80-9 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
Distillates (petroleum), hydrotreated middle | 265-148-2 | 64742-46-7 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
Extracts (petroleum), deasphalted vacuum residue solvent | 295-332-8 | 91995-70-9 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
Extracts (petroleum), residual oil solvent | 265-110-5 | 64742-10-5 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
Gas oils (petroleum), hydrodesulfurized | 265-182-8 | 64742-79-6 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid | 940-877-5 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
29/03/2019 29/03/2019 |
13/05/2019 13/05/2019 |
Details | |
Perfluamine | 206-420-2 | 338-83-0 |
Genetic toxicity in vivo (Mammalian Erythrocyte Micronucleus Test) Genetic toxicity in vivo (In vivo Mammalian Alkaline Comet Assay) Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
29/03/2019 29/03/2019 29/03/2019 29/03/2019 |
13/05/2019 13/05/2019 13/05/2019 13/05/2019 |
Details | |
2-Propyn-1-ol, reaction product with 1-2.5 moles of oxirane | 941-793-1 | - | Reproductive toxicity (pre-natal developmental toxicity) | 26/04/2019 | 10/06/2019 | Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 | Reproductive toxicity (pre-natal developmental toxicity) | 26/04/2019 | 10/06/2019 | Details | |
Propylidynetrimethyl trimethacrylate | 221-950-4 | 3290-92-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/04/2019 | 10/06/2019 | Details | |
Strontium neodecanoate | 812-724-1 | 106705-37-7 | Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with [Strontium oxide] (EC 215-219-9) | 26/04/2019 | 10/06/2019 | Details | |
3-(trimethoxysilyl)propylamine | 237-511-5 | 13822-56-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
Biphenyl-4,4'-diol | 202-200-5 | 92-88-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
Ethylenediamine, propoxylated | 500-035-6 | 25214-63-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol | 246-771-9 | 25265-77-4 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 10/06/2019 |
Details | |
Zinc, O,O-mixed (iso-Bu), (iso-Pr), (pentyl) phosphorodithioate | 820-225-5 | 101747-77-7 |
Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0) Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0) Reproductive toxicity (pre-natal developmental toxicity) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0) |
26/04/2019 26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 10/06/2019 |
Details | |
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 246-678-3 | 25155-25-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/05/2019 | 11/07/2019 | Details | |
Alcohols, C11-14-iso-, C13-rich | 271-235-6 | 68526-86-3 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate | 401-100-0 | - | Sub-chronic toxicity (90-day): oral | 27/05/2019 | 11/07/2019 | Details | |
Furan-2,5-dicarboxylic acid | 221-800-8 | 3238-40-2 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
Hexanal | 200-624-5 | 66-25-1 | Genetic toxicity in vivo “|| Note: Testing proposal is based on concern identified by the registrant.” | 27/05/2019 | 11/07/2019 | Details | |
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- | 911-490-9 | - | Sub-chronic toxicity (90-day): oral | 27/05/2019 | 11/07/2019 | Details | |
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol | 907-996-4 | - | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) | 27/05/2019 | 11/07/2019 | Details | |
Reaction Mass of Benzyl (1R,1S) 2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl benzene-1,2-dicarboxylate and Benzyl (3R,3S) 2,2,4-trimethyl-3-[(2-methylpropanoyl)oxy]pentyl benzene-1,2-dicarboxylate | 701-008-3 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/05/2019 | 11/07/2019 | Details | |
Sodium hydroxymethanesulphinate | 205-739-4 | 149-44-0 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts | 601-601-6 | 119345-04-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
Lithium bis(oxalato)borate | 456-990-3 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
Methylphosphonic acid | 213-607-2 | 993-13-5 |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
tri{[(2s)-1-ethoxy-1-oxopropan-2-yl]oxy}(vinyl)silane | 701-301-6 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
Reaction mass of Octadecanamide, 12-hydroxy-N-[2-[(1-oxodecyl)amino]ethyl]- and N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) and Decanamide, N,N'-1,2-ethanediylbis- | 907-495-0 | - |
Reproductive toxicity (pre-natal developmental toxicity): in rat and rabbit Sub-chronic toxicity (90 day): inhalation Reproductive toxicity (extended one-generation reproductive toxicity study) |
27/05/2019 27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 11/07/2019 |
Details | |
Asphalt | 232-490-9 | 8052-42-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
[note whilst the registrant has selected the drop down of a RaX TPE – it is not a RaX TPE – registered substance is being tested]” |
25/06/2019 | 09/08/2019 | Details | |
Asphalt, oxidized | 265-196-4 | 64742-93-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2019 | 09/08/2019 | Details | |
Benzyltoluene | 248-654-8 | 27776-01-8 | Long-term toxicity to fish (OECD 210) | 25/06/2019 | 09/08/2019 | Details | |
Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide | 229-782-3 | 6731-36-8 | Bioaccumulation aquatic / sediment | 25/06/2019 | 09/08/2019 | Details | |
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. | 276-014-8 | 71786-60-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2019 | 09/08/2019 | Details | |
Hexamethyldisiloxane | 203-492-7 | 107-46-0 | Reproductive toxicity (pre-natal developmental toxicity) with the rabbit via inhalation | 25/06/2019 | 09/08/2019 | Details | |
pentasodium 5-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}-3-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-4-hydroxynaphthalene-2,7-disulfonate | 402-420-3 | 89157-03-9 | Sub-chronic toxicity (90-day): oral | 25/06/2019 | 09/08/2019 | Details | |
Residues (petroleum), thermal cracked vacuum | 295-518-9 | 062-05-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Asphalt (CAS 8052-42-4) | 25/06/2019 | 09/08/2019 | Details | |
Residues (petroleum), vacuum | 265-057-8 | 64741-56-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2019 | 09/08/2019 | Details | |
Strontium oxide | 215-219-9 | 1314-11-0 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2019 | 09/08/2019 | Details | |
Triisotridecyl phosphite | 278-758-9 | 77745-66-5 | Sub-chronic toxicity (90-day): oral | 25/06/2019 | 09/08/2019 | Details | |
Fatty acids, C12-14, α-sulfo, disodium salts | 942-523-5 | - |
Long-term toxicity to fish (OECD 212 – Registrant’s preference) Sub-chronic toxicity (90-day): oral on rodents Reproductive toxicity (pre-natal developmental toxicity) on rodents |
25/06/2019 25/06/2019 25/06/2019 |
09/08/2019 09/08/2019 09/08/2019 |
Details | |
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 254-996-9 | 40601-76-1 | Reproductive toxicity (pre-natal developmental toxicity) with Rat | 24/07/2019 | 09/09/2019 | Details | |
4-fluoro-1,3-dioxolan-2-one | 483-360-5 | 114435-02-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
Bis(2-chloroethyl) 3,3'-[(2,5-dimethyl-p-phenylene)bis[iminocarbonyl(2-hydroxy-1,3-naphthylene)azo]]di-p-toluate | 269-507-4 | 68259-05-2 | Sub-chronic toxicity (90 day): inhalation || Note: Testing proposal is based on concern identified by the registrant | 24/07/2019 | 09/09/2019 | Details | |
Heptanoic acid | 203-838-7 | 111-14-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 24/07/2019 | 09/09/2019 | Details | |
Reaction mass of trans-Cyclohexadecen-8-one, cis-Cyclohexadecen-8-one, trans-Cyclohexadecen-7-one, cis-Cyclohexadecen-7-one | 448-300-4 | 88642-03-9 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
Sodium dihydrogenorthophosphate | 231-449-2 | 7558-80-7 | Sub-chronic toxicity (90-day): oral | 24/07/2019 | 09/09/2019 | Details | |
Sophorolipids: fermentation products of glucose and fatty acids, C18 (unsaturated), glycerol esters with yeast Candida Bombicola, partially hydrolysed | 941-809-7 | - | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
Sodium diisobutyldithiophosphinate | 236-419-2 | 13360-78-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) with Rat |
24/07/2019 24/07/2019 |
09/09/2019 09/09/2019 |
Details | |
Benzene, diethenyl- and Benzene, ethenylethyl- | 910-757-7 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
16/08/2019 16/08/2019 |
30/09/2019 30/09/2019 |
Details | |
N,N'-dimethyldiphenylthiuram disulphide | 234-196-6 | 10591-84-1 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
16/08/2019 16/08/2019 |
30/09/2019 30/09/2019 |
Details | |
Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol | 911-819-6 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
16/08/2019 16/08/2019 |
30/09/2019 30/09/2019 |
Details | |
1-aminopropan-2-ol | 201-162-7 | 78-96-6 | Reproductive toxicity (pre-natal developmental toxicity) | 17/09/2019 | 01/11/2019 | Details | |
2,2'-(cyclohexylimino)bisethanol | 224-809-5 | 4500-29-2 | Reproductive toxicity (pre-natal developmental toxicity) | 17/09/2019 | 01/11/2019 | Details | |
Butanoic acid, 4-amino-4-oxo-2(or 3)-sulfo-,N-(C16-C18 (even numbered), C18 unsaturated alkyl)), disodium salts | 939-691-7 | - | Reproductive toxicity (pre-natal developmental toxicity) | 17/09/2019 | 01/11/2019 | Details | |
Hydroxycyclohexyl phenyl ketone | 213-426-9 | 947-19-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 17/09/2019 | 01/11/2019 | Details | |
2,4,7,9-tetramethyl-4,7-decanediol | 451-160-7 | 17913-76-7 |
Long-term toxicity to fish "|| Note: testing proposed with 2,4,7,9-tetramethyldec-5-yne-4,7-diol (EC 204-809-1, CAS 126-86-3) Reproductive toxicity (pre-natal developmental toxicity) |
17/09/2019 17/09/2019 |
01/11/2019 01/11/2019 |
Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with triethylenetetramine | 500-290-3 | 103758-99-2 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5) |
17/09/2019 17/09/2019 |
01/11/2019 01/11/2019 |
Details | |
tetrasodium 7-[(E)-2-[2-(carbamoylamino)-4-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}phenyl]diazen-1-yl]naphthalene-1,3,6-trisulfonate | 474-870-9 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
17/09/2019 17/09/2019 |
01/11/2019 01/11/2019 |
Details | |
2,2-bis[[(1-oxopentyl)oxy]methyl]propane-1,3-diyl divalerate | 239-937-7 | 15834-04-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2019 | 05/12/2019 | Details | |
2-(2-(2-methoxyethoxy)ethoxy)ethanol | 203-962-1 | 112-35-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2019 | 05/12/2019 | Details | |
2-(2-methoxyethoxy)ethanol | 203-906-6 | 111-77-3 | Reproductive toxicity (pre-natal developmental toxicity) | 21/10/2019 | 05/12/2019 | Details | |
N,N-bis(2-ethylhexyl)-5-methyl-1H-benzotriazole-1-methylamine, N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-4-methyl-, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-5-methyl-, 1H-Benzotriazole-1-methanamine, N,N-bis(2-ethylhexyl)-6-methyl-(Mixture) | 939-700-4 | - | Sub-chronic toxicity (90-day): oral | 21/10/2019 | 05/12/2019 | Details | |
Reaction mass of 2,2'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxymethylene]}dioxirane and 1,3-bis{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol and 3,3'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxy]}bis(1-{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol) | 941-357-0 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2019 | 05/12/2019 | Details | |
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with Propylene oxide and n-butyl glycidyl ether | 926-564-6 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
21/10/2019 21/10/2019 |
05/12/2019 05/12/2019 |
Details | |
2,4,7,9-Tetramethyldec-5-yne-4,7-diol, ethoxylated | 500-022-5 | 9014-85-1 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 2,4,7,9-Tetramethyl-5-decyne-4,7-diol (CAS number 126-86-3) || |
25/11/2019 | 09/01/2020 | Details | |
2-hydroxy-3-propyl-2H-furan-5-one | 821-451-7 | 78920-10-2 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. || |
25/11/2019 | 09/01/2020 | Details | |
Heptanal | 203-898-4 | 111-71-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Heptanoic acid (CAS No. 111-14-8) |
25/11/2019 | 09/01/2020 | Details | |
Hexaboron dizinc undecaoxide | 235-804-2 | 12767-90-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. |
25/11/2019 | 09/01/2020 | Details | |
Reaction mass of ethoxylated (= 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate | 939-702-5 | - | Long-term toxicity to fish | 25/11/2019 | 09/01/2020 | Details | |
2,2'-(octylimino)bisethanol | 239-555-0 | 15520-05-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/11/2019 25/11/2019 |
09/01/2020 09/01/2020 |
Details | |
3-[(3-{[(3-acetoxy-2,2-dimethylpropylidene)amino]methyl}-3,5,5-trimethylcyclohexyl)imino]-2,2-dimethylpropyl acetate | 805-722-7 | 1064082-81-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
isliFe | - | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
Sodium hydrogen N-(1-oxotetradecyl)-L-glutamate | 253-981-4 | 38517-37-2 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with L-Glutamic acid, N-coco acyl derivs., disodium salts (CAS number: 68187-30-4; EC number: 269-085-1) || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate | 950-225-1 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8) |
17/12/2019 17/12/2019 |
31/01/2020 31/01/2020 |
Details | |
1-imino-1H-isoindol-3-amine | 222-426-8 | 3468-11-9 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
2-(2-(2-butoxyethoxy)ethoxy)ethanol | 205-592-6 | 143-22-6 | Reproductive toxicity (pre-natal developmental toxicity): 1st PNDT on the registered substance 2nd PNDT with the registered substance // Note: Testing proposal for an EOGRTS proposed to be conducted with the analogue substance 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1, CAS 112-35-6) | 27/01/2020 | 12/03/2020 | Details | |
4,4'-[(isopropylidene)bis(p-phenyleneoxy)]diphthalic dianhydride | 253-781-7 | 38103-06-9 | Sub-chronic toxicity (90-day): oral | 27/01/2020 | 12/03/2020 | Details | |
4,4'-methylenebis[N-sec-butylaniline] | 226-122-6 | 5285-60-9 | Bioaccumulation aquatic / sediment | 27/01/2020 | 12/03/2020 | Details | |
4-chloroformylphthalic anhydride | 214-874-8 | 1204-28-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate | 220-482-8 | 2781-11-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
Ethylenediamine, salt with phosphoric acid | 238-914-9 | 14852-17-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/01/2020 | 12/03/2020 | Details | |
m-phenylene di(acetate) | 203-596-2 | 108-58-7 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine | 264-438-6 | 63738-22-7 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol | 907-996-4 | - | Reproductive toxicity (pre-natal developmental toxicity) 1st and 2nd PNDTs: || Note: testing proposed with 2-92-92-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) | 27/01/2020 | 12/03/2020 | Details | |
Tetramethylammonium hydroxide | 200-882-9 | 75-59-2 | Sub-chronic toxicity (90-day): oral // Note: testing proposed with Tetramethylammonium chloride (EC 200-880-8) || Note: Link to justification in the registration dossier not given as the information is confidential | 27/01/2020 | 12/03/2020 | Details | |
1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol | 264-261-4 | 63469-23-8 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
2,2'-isopropylidenebis(p-phenyleneoxy)diethanol | 212-985-6 | 901-44-0 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
3-[[3-[[(2-cyanoethyl)amino]methyl]-3,5,5-trimethylcyclohexyl]amino]propiononitrile | 300-496-1 | 93940-97-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
Diethyl ethylphosphonate | 201-111-9 | 78-38-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
N,N'-diphenyl-p-phenylenediamine | 200-806-4 | 74-31-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
Reaction products of orthoboric acid with 2,2'-iminodiethanol (1:1) | 701-083-2 | - |
Sub-chronic toxicity (90-day): oral “||Note: testing proposed with MEA Polyborate (EC 701-025-6)” "Reproductive toxicity (pre-natal developmental toxicity)
“||Note: testing proposed with MEA Polyborate (EC 701-025-6)” |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
Sodium salts of [hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid (4-7 Na:1) | 947-369-2 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
tetrahydro-2-methylfuran | 202-507-4 | 96-47-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 260-829-0 | 57583-35-4 |
Sub-chronic toxicity (90-day): oral Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- | 500-012-0 | 9004-77-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1). Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
Reaction products of monoethanolamine and boric acid (1:1) | 701-025-6 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
Reaction products of monoethanolamine and boric acid (1:3) | 701-024-0 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] | 284-366-9 | 84852-53-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 24/02/2020 | 09/04/2020 | Details | |
1,4-phenylenebis[(4-phenoxyphenyl)methanone] | 620-097-9 | 54299-17-1 | Bioaccumulation test in Fish, Reproductive toxicity (pre-natal developmental toxicity) | 24/02/2020 | 09/04/2020 | Details | |
3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate | 261-665-2 | 59219-71-5 | Sub-chronic toxicity (90-day): oral | 24/02/2020 | 09/04/2020 | Details | |
4-tert-butylcyclohexyl acetate | 250-954-9 | 32210-23-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with cis-4-tert-butylcyclohexyl acetate |
24/02/2020 | 09/04/2020 | Details | |
Camphene | 201-234-8 | 79-92-5 | Sub-chronic toxicity (90-day): oral | 24/02/2020 | 09/04/2020 | Details | |
(1S)-1,5-anhydro-2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol | 695-878-0 | 1283129-18-9 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide | 686-241-8 | 81058-27-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
Dibutyl itaconate | 218-451-9 | 2155-60-4 |
Sub-chronic toxicity (90-day): oral Genetic toxicity in vivo |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
Etocrilene | 226-029-0 | 5232-99-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
Fluorobenzene | 207-321-7 | 462-06-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
N,N,2,8-tetramethyl-5,11-dioxa-2,8-diazatridecan-13-amine | 695-748-3 | 65286-55-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide | 806-543-7 | 215917-77-4 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
reaction products of benzaldehyde diethylenetriamine and triethylenetetramine, hydrogenated | 846-447-2 | 1219458-07-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
(Z)-4-[C11-13 (branched) alkylamino]-4-oxo-2-butenoic acid | 701-116-0 | - | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
1,4-bis(2,3-epoxypropoxy)butane | 219-371-7 | 2425-79-8 | Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane (1:2) (EC 618-939-5) | 23/03/2020 | 07/05/2020 | Details | |
2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate | 224-116-8 | 4203-89-8 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
2-[[(butylamino)carbonyl]oxy]ethyl acrylate | 264-036-0 | 63225-53-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 23/03/2020 | 07/05/2020 | Details | |
2-isocyanatoethyl methacrylate | 250-284-7 | 30674-80-7 | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
4-phenylbutenone | 204-555-1 | 122-57-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
Dialkyl-methyl-dihydro-heteropolycyle | 815-131-6 | 913171-06-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/03/2020 | 07/05/2020 | Details | |
Dimethyl (p-methoxybenzylidene)malonate | 231-185-8 | 7443-25-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 23/03/2020 | 07/05/2020 | Details | |
Dioctyltin dilaurate | 222-883-3 | 3648-18-8 | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide | 810-703-1 | 1187441-10-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
tert-butyl perbenzoate | 210-382-2 | 614-45-9 | Long-term toxicity to fish | 23/03/2020 | 07/05/2020 | Details | |
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate | 255-901-3 | 42594-17-2 |
Reproductive toxicity (pre-natal developmental toxicity) Bioaccumulation test (Bioconcentration: Flow-through Fish Test) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
4-(1,1-dimethylethyl)cyclohexyl acrylate | 282-104-8 | 84100-23-2 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
N,N''-(4-methyl-m-phenylene)bis[N',N'-dimethylurea] | 241-523-6 | 17526-94-2 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid | 931-291-0 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
Benzyldimethylamine | 203-149-1 | 103-83-3 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 07/05/2020 |
Details | |
Distillates (petroleum), hydrodesulfurized middle | 265-183-3 | 64742-80-9 | Genetic toxicity in vivo | 14/05/2020 | 29/06/2020 | Details | |
Distillates (petroleum), hydrotreated middle | 265-148-2 | 64742-46-7 | Genetic toxicity in vivo | 14/05/2020 | 29/06/2020 | Details | |
Gas oils (petroleum), hydrodesulfurized | 265-182-8 | 64742-79-6 | Genetic toxicity in vivo | 14/05/2020 | 29/06/2020 | Details | |
(3-chloropropyl)dimethoxymethylsilane | 242-056-0 | 18171-19-2 | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
(R)-p-mentha-1,8-diene | 227-813-5 | 5989-27-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/05/2020 | 09/07/2020 | Details | |
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters | 701-339-3 | - | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
1,3-Propanediamine, N-[3-((C11-14, C13-rich)oxy)propyl]- branched acetate | 931-295-2 | - | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
1-(4-(ACETYLOXY)-3-((ACETYLOXY)METHYL)PHENYL)ETHANONE | 921-042-4 | - | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
2,4,6,8,10-pentamethylcyclopentasiloxane | 228-204-7 | 6166-86-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (EC 219-137-4) | 25/05/2020 | 09/07/2020 | Details | |
2,4,6,8-tetramethylcyclotetrasiloxane | 219-137-4 | 2370-88-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/05/2020 | 09/07/2020 | Details | |
4,4'-isopropylidenedi-o-cresol | 201-240-0 | 79-97-0 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 218-664-7 | 2212-81-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide CAS: 25155-25-3)” | 25/05/2020 | 09/07/2020 | Details | |
Choline hydroxide | 204-625-1 | 123-41-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Choline chloride (EC 200-655-4) | 25/05/2020 | 09/07/2020 | Details | |
Dichlorobis(η-cyclopentadienyl)titanium | 215-035-9 | 1271-19-8 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
Dimethoxymethylsilane | 240-914-9 | 16881-77-9 | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
hexadecyltrimethoxysilane | 240-464-3 | 16415-12-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/05/2020 | 09/07/2020 | Details | |
Lithium phosphorodifluoridate | 643-080-8 | 24389-25-1 | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
Lithium tetrafluoroborate, anhydrous | 238-178-9 | 14283-07-9 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine | 264-761-2 | 64265-45-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
p-tert-butylstyrene | 217-126-9 | 1746-23-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
Phosphoric acid, 2-ethylhexyl ester | 235-741-0 | 12645-31-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
Platinum(IV) aqua hydroxo nitrato complexes | 701-319-4 | - | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
Platinum, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane complexes | 701-315-2 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
Reaction mass of 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane and 4,4,14,14-tetraethoxy-3,15-dioxa-8,9,10-trithia-4,14-disilaheptadecane | 915-748-1 | - | Sub-chronic toxicity (90-day): oral || Note: testing proposed with polysulfides, bis[3-(triethyoxysilyl)propyl (CAS No 211519-85-6) | 25/05/2020 | 09/07/2020 | Details | |
Reaction mass of sodium 1-methoxy-1-oxohexadecane-2-sulphonate and sodium methyl 2-sulphooctadecanoate | 911-616-2 | - | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
Sodium 1-hydroxyethanesulphonate | 213-037-4 | 918-04-7 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
triethoxy(methyl)silane | 217-983-9 | 2031-67-6 | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
Zinc bis(benzenesulphinate) | 246-148-1 | 24308-84-7 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |