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Predchádzajúce/výsledok

Predchádzajúce/výsledok

Predchádzajúce/výsledok

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 

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Stránka 7 z 11
200 Položiek na stránku
Ukazujem 1 201 - 1 400 z 2 011 výsledkov.
Name
EC Number
CAS Number
Hazard endpoint for which vertebrate testing was proposed
Date of publication to call for available information
Deadline for submitting information
Alternatives to vertebrate testing
 
(E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene 807-113-1 3709-71-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
19/10/2020
19/10/2020
03/12/2020
03/12/2020
 Details
Octa-1,7-diene 223-054-9 3710-30-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
 Details
2,4-Pentanedione, peroxide 253-384-9 37187-22-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/11/2015
30/11/2015
14/01/2016
14/01/2016
 Details
2-Oxepanone, polymer with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol 500-099-5 37625-56-2 Reproductive toxicity (pre-natal developmental toxicity) 15/07/2011 29/08/2011 Details
2-phosphonobutane-1,2,4-tricarboxylic acid 253-733-5 37971-36-1
Long-term toxicity to fish||Note: testing proposed with Tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarbolxyate, (EC No. 266-442-3)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarbolxyate, (EC No. 266-442-3)
26/10/2022
26/10/2022
12/12/2022
12/12/2022
 Details
4,4'-[(isopropylidene)bis(p-phenyleneoxy)]diphthalic dianhydride 253-781-7 38103-06-9 Sub-chronic toxicity (90-day): oral 27/01/2020 12/03/2020 Details
2-Propyn-1-ol, compd. with methyloxirane 609-530-2 38172-91-7 Sub-chronic toxicity (90-day): oral 16/10/2014 01/12/2014 Details
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 3-aminomethyl-3,5,5-trimethylcyclohexylamine 500-101-4 38294-64-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2014
15/04/2014
30/05/2014
30/05/2014
 Details
D-glucopyranose, oligomeric, C10-16 glycosides (even numbered), carboxymethyl ethers, sodium salts 609-542-8 383178-66-3 Reproductive toxicity (pre-natal developmental toxicity) 30/11/2015 14/01/2016 Details
bis(3,5,5-trimethylhexanoyl) peroxide 223-356-0 3851-87-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
 Details
Sodium hydrogen N-(1-oxotetradecyl)-L-glutamate 253-981-4 38517-37-2 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with L-Glutamic acid, N-coco acyl derivs., disodium salts (CAS number: 68187-30-4; EC number: 269-085-1) || Note: Testing proposal is based on concern identified by the registrant. 17/12/2019 31/01/2020 Details
1,1'-(p-tolylimino)dipropan-2-ol 254-075-1 38668-48-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/03/2016
17/04/2015
28/04/2016
04/06/2015
 Details
[hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid, potassium salt 254-135-7 38820-59-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
 Details
(phenylethyl)benzene 254-179-7 38888-98-1 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014 Details
2,6,10-trimethyldodecane 622-542-2 3891-98-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
 Details
Bumetrizole 223-445-4 3896-11-5 Bioaccumulation aquatic / sediment 18/06/2018 02/08/2018 Details
Sodium chloroacetate 223-498-3 3926-62-3 Reproductive toxicity (two-generation reproductive toxicity) 16/06/2011 01/08/2011 Details
Sodium chloroacetate 223-498-3 3926-62-3 Reproductive toxicity (pre-natal developmental toxicity) 14/10/2011 28/11/2011 Details
Phosphoric acid, dodecyl ester, potassium salt 254-414-3 39322-78-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
 Details
Nonane-1,9-diol 223-517-5 3937-56-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
05/07/2018
05/07/2018
20/08/2018
20/08/2018
 Details
Nonane-1,9-diol 223-517-5 3937-56-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
16/12/2020
16/12/2020
01/02/2021
01/02/2021
 Details
Phosphoric acid, octadecyl ester 254-466-7 39471-52-8
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/04/2015
17/04/2015
17/04/2015
17/04/2015
04/06/2015
04/06/2015
04/06/2015
04/06/2015
 Details
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate 254-588-0 39670-09-2
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
30/06/2014
30/06/2014
 Details
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane 500-107-7 40039-93-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
 Details
2,3-epoxypropyl isopropyl ether 223-672-9 4016-14-2 Genetic toxicity in vivo 19/10/2020 03/12/2020 Details
(2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)tri-2,1-ethanediyl triacrylate 254-843-6 40220-08-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 19/10/2020 03/12/2020 Details
2-(2-thienyl)ethyl toluene-p-sulphonate 254-911-5 40412-06-4 Genetic toxicity in vivo 06/09/2018 22/10/2018 Details
2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]ethyl ethyl carbonate 254-959-7 40530-60-7 Genetic toxicity in vivo || Note: testing proposed with Disperse Red 302:1 (EC 248-882-8) 23/11/2020 07/01/2021 Details
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 254-996-9 40601-76-1 Reproductive toxicity (pre-natal developmental toxicity) with Rat 24/07/2019 09/09/2019 Details
3,6,9,12-tetraazatetradecamethylenediamine 223-775-9 4067-16-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with structural analogues TETA (CAS 90640-67-8) and HEPA (CAS 68121-73-7).
Reproductive toxicity (pre-natal developmental toxicity)
22/11/2017
22/11/2017
08/01/2018
08/01/2018
 Details
3,6,9,12-tetraazatetradecamethylenediamine 223-775-9 4067-16-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
28/02/2011
28/02/2011
14/04/2011
14/04/2011
 Details
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide 223-829-1 4090-51-1 Sub-chronic toxicity (90-day): oral 16/06/2022 01/08/2022 Details
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate 255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
30/06/2014
 Details
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate  255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2016
16/12/2016
16/12/2016
30/01/2017
30/01/2017
30/01/2017
 Details
Tris(p-isocyanatophenyl) thiophosphate 223-981-9 4151-51-3 6.1.2 Long-term toxicity to fish 08/03/2024 22/04/2024 Details
Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate 223-989-2 4156-21-2 Sub-chronic toxicity (90-day): oral 29/04/2014 13/06/2014 Details
Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate 223-989-2 4156-21-2 Reproductive toxicity (pre-natal developmental toxicity) 03/04/2023 22/05/2023 Details
1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone 255-460-7 41611-76-1 Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014 Details
2,2-dimethylpropane-1,3-diyl dibenzoate 224-081-9 4196-89-8 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016 Details
2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate 224-116-8 4203-89-8 Genetic toxicity in vivo 23/03/2020 07/05/2020 Details
Isononyl isononanoate 609-993-0 42131-25-9 Sub-chronic toxicity (90-day): oral 18/09/2014 03/11/2014 Details
3,3'-oxybis(ethyleneoxy)bis(propylamine) 224-207-2 4246-51-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2021
18/02/2021
05/04/2021
05/04/2021
 Details
methylsilanetriyl triacetate 224-221-9 4253-34-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [Trimethoxy(methyl)silane] (EC 214-685-0) 16/03/2015 30/04/2015 Details
methylsilanetriyl triacetate 224-221-9 4253-34-3 Sub-chronic toxicity (90-day): oral||Note: testing proposed with [triethoxy(methyl)silane] (CAS no. 2031-67-6) 03/10/2023 17/11/2023 Details
Di-tert-butyl trisulphide 224-226-6 4253-90-1 Long-term toxicity to fish 30/06/2023 14/08/2023 Details
Di-tert-butyl trisulphide 224-226-6 4253-90-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
01/03/2023
01/03/2023
01/03/2023
17/04/2023
17/04/2023
17/04/2023
 Details
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) 224-235-5 4259-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
 Details
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) 224-235-5 4259-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
 Details
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate 255-901-3 42594-17-2
Bioaccumulation test (Bioconcentration: Flow-through Fish Test)
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
 Details
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate 255-901-3 42594-17-2
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
22/04/2021
22/04/2021
22/04/2021
07/06/2021
07/06/2021
07/06/2021
 Details
2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) 02/11/2018 17/12/2018 Details
Isohexadecane 2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/05/2022
10/05/2022
27/06/2022
27/06/2022
 Details
4-morpholinecarbaldehyde 224-518-3 4394-85-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
 Details
4-morpholinecarbaldehyde 224-518-3 4394-85-8 Sub-chronic toxicity (90-day): oral 04/04/2014 19/05/2014 Details
3-trimethoxysilylpropane-1-thiol 224-588-5 4420-74-0 Long-term toxicity to fish||Note: testing proposed with 3-Triethoxysilylpropane-1-thiol (EC no. 238-883-1) 22/09/2022 07/11/2022 Details
3-trimethoxysilylpropane-1-thiol 224-588-5 4420-74-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1) || Note: Testing proposal is based on concern identified by the registrant.
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1) || Note: Testing proposal is based on concern identified by the registrant.
23/11/2020
23/11/2020
07/01/2021
07/01/2021
 Details
Vinyl ethylene carbonate 700-261-7 4427-96-7 Sub-chronic toxicity (90-day): oral 30/06/2023 14/08/2023 Details
3-methylpentane-1,5-diol 224-709-1 4457-71-0 Long-term toxicity to fish 01/03/2023 17/04/2023 Details
2,2'-(cyclohexylimino)bisethanol 224-809-5 4500-29-2 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019 Details
1,5-Diisocyanatopentane 807-040-5 4538-42-5 Long-term toxicity to fish 30/06/2023 14/08/2023 Details
Fluorobenzene 207-321-7 462-06-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
24/02/2020
24/02/2020
09/04/2020
09/04/2020
 Details
Calcium carbonate 207-439-9 471-34-1 Sub-chronic toxicity (90 day): inhalation 15/07/2011 29/08/2011 Details
Octylphosphonic acid 225-218-5 4724-48-5 Sub-chronic toxicity (90-day): oral 03/04/2023 22/05/2023 Details
Octylphosphonic acid 225-218-5 4724-48-5 Reproductive toxicity (pre-natal developmental toxicity) 16/05/2014 30/06/2014 Details
1,8-naphthylenediamine 207-529-8 479-27-6 Genetic toxicity in vivo 22/04/2021 07/06/2021 Details
Tetrasodium 2-(4-fluoro-6-(2-(2-sulfonatoethansulfonyl)ethylamino)-1,3,5-triazin-2-ylamino)-5-hydroxy-6-(2-(2-hydroxy-5-sulfonatophenylazo)-4,5-dimethoxyphenylazo)-7-sulfonatonaphthalene-1-sulfonatocuprate(II) 442-640-7 479541-17-8 Genetic toxicity in vivo 03/10/2023 17/11/2023 Details
2-phenoxyethyl acrylate 256-360-6 48145-04-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2014
15/04/2014
30/05/2014
30/05/2014
 Details
Fluoren-9-one 207-630-7 486-25-9 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 23/11/2020 07/01/2021 Details
Quinazolin-4(1H)-one 207-735-8 491-36-1 Genetic toxicity in vivo 23/11/2020 07/01/2021 Details
arbonohydrazide 207-837-2 497-18-7
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2014
18/02/2014
04/04/2014
04/04/2014
 Details
8,9,10-trinorborn-2-ene 207-866-0 498-66-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/11/2015
01/11/2015
16/12/2015
16/12/2015
 Details
8,9,10-trinorborn-2-ene 207-866-0 498-66-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2011
16/06/2011
01/08/2011
01/08/2011
 Details
N-(3-aminopropyl)iminodiethanol 225-642-0 4985-85-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
 Details
Hexan-6-olide 207-938-1 502-44-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/12/2020
16/12/2020
01/02/2021
01/02/2021
 Details
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 225-716-2 5026-74-4
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
 Details
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 225-716-2 5026-74-4
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
 Details
1,3-dioxepane 208-015-6 505-65-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
 Details
Potassium dicyanoargentate 208-047-0 506-61-6 Genetic toxicity in vivo 17/06/2020 03/08/2020 Details
Guanidinium nitrate 208-060-1 506-93-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/09/2012
25/09/2012
12/11/2012
12/11/2012
 Details
N-isopropylhydroxylamine 225-791-1 5080-22-8
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
 Details
(3-chloropropyl)triethoxysilane 225-805-6 5089-70-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/10/2022
26/10/2022
12/12/2022
12/12/2022
 Details
4-(1-oxo-2-propenyl)-morpholine 418-140-1 5117-12-4 Genetic toxicity in vivo 21/09/2020 05/11/2020 Details
1,1,3,3-tetramethylbutyl peroxyneodecanoate 257-077-0 51240-95-0 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant 01/09/2017 16/10/2017 Details
1,1,3,3-tetramethylbutyl peroxyneodecanoate 257-077-0 51240-95-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
17/07/2014
17/07/2014
 Details
Barium carbonate 208-167-3 513-77-9 Long-term toxicity to fish 29/04/2011 14/06/2011 Details
Barium carbonate 208-167-3 513-77-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/12/2011
16/12/2011
30/01/2012
30/01/2012
 Details
cobalt carbonate 208-169-4 513-79-1
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4)
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2)
21/01/2021
21/01/2021
08/03/2021
08/03/2021
 Details
Cobalt(II) carbonate 208-169-4 513-79-1
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
 Details
2-(2-Ethoxyethoxy)-2-methylpropanee 257-196-8 51422-54-9 Sub-chronic toxicity (90 day): inhalation Reproductive toxicity (pre-natal developmental toxicity) 03/02/2016 21/03/2016 Details
3,7-dimethyloct-6-enenitrile 257-288-8 51566-62-2 Reproductive toxicity (pre-natal developmental toxicity) 03/03/2014 17/04/2014 Details
Dihydrogen hexahydroxyplatinate 257-471-2 51850-20-5 Genetic toxicity in vivo || Note: testing proposed with dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) (EC 268-717-3) 21/12/2021 04/02/2022 Details
Dihydrogen hexahydroxyplatinate 257-471-2 51850-20-5 Genetic toxicity in vivo || Note: Testing proposed with dihydrogen hexahydroxyplatinate(IV), compound with 2-aminoethanol (1:2). Testing proposal is based on concern identified by the registrant. 28/02/2018 16/04/2018 Details
N-[2-[(2-bromo-4,6-dinitrophenyl)azo]-5-(diallylamino)-4-methoxyphenyl]acetamide 257-486-4 51868-46-3 Genetic toxicity in vivo 26/10/2022 12/12/2022 Details
5-ethyl-1,3-dioxane-5-methanol 225-967-8 5187-23-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2014
31/01/2014
17/03/2014
17/03/2014
 Details
5-ethyl-1,3-dioxane-5-methanol 225-967-8 5187-23-5
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
03/10/2023
03/10/2023
03/10/2023
17/11/2023
17/11/2023
17/11/2023
 Details
N-[3-(dimethylamino)propyl]methacrylamide 226-002-3 5205-93-6 Reproductive toxicity (pre-natal developmental toxicity) 29/04/2011 14/06/2011 Details
Etocrilene 226-029-0 5232-99-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
24/02/2020
24/02/2020
09/04/2020
09/04/2020
 Details
4-[3-(1-naphthylamino)propyl]morpholine 226-033-2 5235-82-5 Genetic toxicity in vivo 19/10/2020 03/12/2020 Details
3-(diethylamino)-7-oxo-7H-[1]benzopyrano[3',2':3,4]pyrido[1,2-a]benzimidazole-6-carbonitrile 257-884-8 52372-36-8 Genetic toxicity in vivo 26/10/2022 12/12/2022 Details
Glycerol, propoxylated, esters with acrylic acid 500-114-5 52408-84-1 Sub-chronic toxicity (90-day): oral 22/11/2017 08/01/2018 Details
1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 257-913-4 52434-90-9
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/04/2023
03/04/2023
03/04/2023
22/05/2023
22/05/2023
22/05/2023
 Details
Poly[oxy(methyl-1,2-ethanediyl)], α,α'-(2,2-dimethyl-1,3-propanediyl)bis[ω-hydroxy-] 610-848-9 52479-58-0 Sub-chronic toxicity (90-day): oral 18/09/2014 03/11/2014 Details
Sodium 3-(allyloxy)-2-hydroxypropanesulphonate 258-004-5 52556-42-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/04/2014
29/04/2014
13/06/2014
13/06/2014
 Details
Bis(O,O-diisopropyl dithiophosphate)bis(cyclohexylamine) zinc 809-986-4 52585-16-7 Genetic toxicity in vivo 22/04/2021 07/06/2021 Details
Zinc, bis[O,O-bis(1-methylethyl) phosphorodithioato-.kappa.S]bis(cyclohexanamine)-, (T-4)- 809-986-4 52585-16-7 Genetic toxicity in vivo 18/06/2018 02/08/2018 Details
2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, phosphate 258-053-2 52628-03-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/04/2014
29/04/2014
13/06/2014
13/06/2014
 Details
octyltrichlorosilane 226-112-1 5283-66-9 Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) 25/06/2015 10/08/2015 Details
4,4'-methylenebis[N-sec-butylaniline] 226-122-6 5285-60-9 Bioaccumulation aquatic / sediment 27/01/2020 12/03/2020 Details
Oligomerisation reaction products of glyoxal and urea 610-945-6 53037-34-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
 Details
Ditetradecyl peroxydicarbonate 258-436-4 53220-22-7
Reproductive toxicity (pre-natal developmental toxicity
Sub-chronic toxicity (90-day): oral
31/01/2018
31/01/2018
19/03/2018
19/03/2018
 Details
Sulphamidic acid 226-218-8 5329-14-6
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
14/02/2011
14/02/2011
14/02/2011
31/03/2011
31/03/2011
31/03/2011
 Details
Sulphamidic acid 226-218-8 5329-14-6 Reproductive toxicity (pre-natal developmental toxicity) 25/11/2021 10/01/2022 Details
Sulphamidic acid 226-218-8 5329-14-6 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with ammonium sulphamate (pH consideration) 23/04/2018 07/06/2018 Details
2-Octyldodecan-1-ol 226-242-9 5333-42-6 Reproductive toxicity (two-generation reproductive toxicity) 05/04/2011 20/05/2011 Details
Sodium O,O-diisobutyl dithiophosphate 258-508-5 53378-51-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
29/04/2014
29/04/2014
13/06/2014
13/06/2014
 Details
2-aminopropane-1,3-diol 208-584-0 534-03-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): oral
17/06/2014
17/06/2014
01/08/2014
01/08/2014
 Details
Sodium 2,4,5-trichlorobenzenesulphonate 258-548-3 53423-65-7 Genetic toxicity in vivo 30/09/2021 15/11/2021 Details
Pentane-1,2-diol 226-285-3 5343-92-0 Sub-chronic toxicity (90-day): oral 16/06/2011 01/08/2011 Details
6,8-Dioxabicyclo[3.2.1]octan-4-one, (1S,5R) (Cyrene) 807-130-4 53716-82-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/08/2021
26/08/2021
11/10/2021
11/10/2021
 Details
4,4'-methylenedi-2,6-xylenol 226-378-9 5384-21-4 Reproductive toxicity (extended one-generation reproductive toxicity study) 03/04/2023 22/05/2023 Details
Ethyl 4-oxovalerate 208-728-2 539-88-8
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with levulinic acid (EC 204-649-2)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with levulinic acid (EC 204-649-2)
23/11/2020
23/11/2020
07/01/2021
07/01/2021
 Details
Citral 226-394-6 5392-40-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018 Details
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione 258-904-8 53988-10-6
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3)
Reproductive toxicity (two-generation reproductive toxicity) Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3)
15/04/2014
15/04/2014
30/05/2014
30/05/2014
 Details
Dodecamethylcyclohexasiloxane 208-762-8 540-97-6 Sub-chronic toxicity (90 day): inhalation 31/05/2011 15/07/2011 Details
Dodecamethylcyclohexasiloxane 208-762-8 540-97-6 Reproductive toxicity (extended one-generation reproductive toxicity study 23/04/2018 07/06/2018 Details
Decamethylcyclopentasiloxane 208-764-9 541-02-6 Reproductive toxicity (pre-natal developmental toxicity) 25/10/2017 11/12/2017 Details
Hexamethylcyclotrisiloxane 208-765-4 541-05-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/10/2022
26/10/2022
12/12/2022
12/12/2022
 Details
5-methylheptan-3-one 208-793-7 541-85-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
03/03/2014
03/03/2014
17/04/2014
17/04/2014
 Details
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] 258-981-8 54112-23-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
12/12/2014
12/12/2014
26/01/2015
26/01/2015
 Details
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] 258-981-8 54112-23-1 Long-term toxicity to fish
Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates. 		31/08/2015 15/10/2015 Details
6-methyl-1,3,5-triazine-2,4-diyldiamine 208-796-3 542-02-9 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014 Details
δ-valerolactone 208-807-1 542-28-9 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
Guanidinium phosphate (1:1) 226-551-9 5423-22-3 Sub-chronic toxicity (90-day): oral 16/05/2014 30/06/2014 Details
Zinc bis[bis(dodecylphenyl)] bis(dithiophosphate) 259-048-8 54261-67-5
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
19/11/2018
19/11/2018

Details
1,4-phenylene bis[(4-phenoxyphenyl)-methanone] 620-097-9 54299-17-1
Bioaccumulation aquatic / sediment
Long-term toxicity to fish
22/11/2017
22/11/2017
08/01/2018
08/01/2018
 Details
1,4-phenylenebis[(4-phenoxyphenyl)methanone] 620-097-9 54299-17-1 Bioaccumulation test in Fish, Reproductive toxicity (pre-natal developmental toxicity) 24/02/2020 09/04/2020 Details
Diisopentyl ether 208-857-4 544-01-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
 Details
Hexadecane 208-878-9 544-76-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/01/2021
21/01/2021
21/01/2021
08/03/2021
08/03/2021
08/03/2021
 Details
Vinyl neononanoate 259-160-7 54423-67-5 Reproductive toxicity (pre-natal developmental toxicity) // Note: testing proposed on rabbits 21/03/2014 05/05/2014 Details
Vinyl neononanoate 259-160-7 54423-67-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018 Details
Vinyl neononanoate 259-160-7 54423-67-5 Sub-chronic toxicity (90 day): oral 16/05/2012 02/07/2012 Details
2-ethylhexyl benzoate 226-641-8 5444-75-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
02/06/2014
17/07/2014
17/07/2014
17/07/2014
 Details
1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethylamine 259-393-4 54914-37-3 Long-term toxicity to fish 03/10/2023 17/11/2023 Details
Lithium carbonate 209-062-5 554-13-2 Reproductive toxicity (two-generation reproductive toxicity) 29/04/2011 14/06/2011 Details
Methyl isothiocyanate 209-132-5 556-61-6 Genetic toxicity in vivo 17/11/2011 02/01/2012 Details
dichlorocyclohexylmethylsilane 226-956-0 5578-42-7 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [dicyclopentyldimethoxysilane] (CAS 126990-35-0) 16/03/2015 30/04/2015 Details
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, esters with acrylic acid 500-130-2 55818-57-0 Reproductive toxicity (pre-natal developmental toxicity) 31/05/2016 15/07/2016 Details
3,3'-iminodi(propylamine) 200-261-2 56-18-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
 Details
benzyltrimethylammonium chloride 200-300-3 56-93-9 Reproductive toxicity (pre-natal developmental toxicity) 31/01/2014 17/03/2014 Details
3-methylbutanone 209-264-3 563-80-4 Sub-chronic toxicity (90 day): inhalation 14/08/2014 28/09/2014 Details
3-methoxy-3-methylbutan-1-ol 260-252-4 56539-66-3 Sub-chronic toxicity (90-day): oral 18/09/2014 03/11/2014 Details
3-methoxy-3-methylbutan-1-ol 260-252-4 56539-66-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 30/09/2021 15/11/2021 Details
3-methoxy-3-methylbutan-1-ol 260-252-4 56539-66-3 Long-term toxicity to fish 26/10/2022 12/12/2022 Details
4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane 260-350-7 56706-10-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/03/2011
15/03/2011
29/04/2011
29/04/2011
 Details
4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane 260-350-7 56706-10-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
23/04/2018
23/04/2018
07/06/2018
07/06/2018
 Details
Formaldehyde, oligomeric reaction products with phenol and m-phenylenebis(methylamine) 500-137-0 57214-10-5
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/11/2015
30/11/2015
30/11/2015
14/01/2016
14/01/2016
14/01/2016
 Details
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 260-829-0 57583-35-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity
Sub-chronic toxicity (90-day): oral
01/09/2016
01/09/2016
01/09/2016
17/10/2016
17/10/2016
17/10/2016
 Details
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 260-829-0 57583-35-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
 Details
Ethyl 4-[[(methylphenylamino)methylene]amino]benzoate 260-976-0 57834-33-0 Genetic toxicity in vivo 10/05/2022 27/06/2022 Details
1,1,3,3-tetramethylbutyl hydroperoxide 227-369-2 5809-08-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
 Details
3,5,5-trimethylhexyl acetate 261-245-9 58430-94-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
 Details
(ethoxymethoxy)cyclododecane 261-332-1 58567-11-6 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
o-(p-isocyanatobenzyl)phenyl isocyanate 227-534-9 5873-54-1 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0) 01/04/2022 16/05/2022 Details
N,N'-hexane-1,6-diylbis(hexahydro-2-oxo-1H-azepine-1-carboxamide) 227-563-7 5888-87-9 Genetic toxicity in vivo 18/09/2014 03/11/2014 Details
4-methylcyclohexanone 209-665-3 589-92-4
6.1.2 Long-term toxicity to fish
7.5.1 Repeated dose toxicity: oral
7.8.2 Developmental toxicity / teratogenicity
08/03/2024
08/03/2024
08/03/2024
22/04/2024
22/04/2024
22/04/2024
 Details
(6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 261-491-7 58909-56-1
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/08/2018
10/08/2018
10/08/2018
24/09/2018
24/09/2018
24/09/2018
 Details
trichloro(hexadecyl)silane 227-575-2 5894-60-0
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
Sub-chronic toxicity (90-day): oral
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
 Details
Potassium cyanate 209-676-3 590-28-3 Reproductive toxicity (two-generation reproductive toxicity) 01/07/2011 15/08/2011 Details
Potassium cyanate 209-676-3 590-28-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018 Details
4,8-Dimethyl-2,5,7,10-tetraoxaundecane 813-999-0 59039-15-5 Long-term toxicity to fish 30/06/2023 14/08/2023 Details
Hex-1-ene 209-753-1 592-41-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
25/06/2012
15/07/2011
15/07/2011
09/08/2012
 Details
3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate 261-665-2 59219-71-5 Sub-chronic toxicity (90-day): oral 24/02/2020 09/04/2020 Details
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate,Bisphenol A Diphosphate,Bisphenol A Polyphosphate 425-220-8 5945-33-5 Reproductive toxicity (two-generation reproductive toxicity) 05/04/2011 20/05/2011 Details
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate,Bisphenol A Diphosphate,Bisphenol A Polyphosphate 425-220-8 5945-33-5 Sub-chronic toxicity (90-day): oral 01/09/2010 15/10/2010 Details
(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate 425-220-8 5945-33-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/08/2021
26/08/2021
11/10/2021
11/10/2021
 Details
O,O,O-triphenyl phosphorothioate 209-909-9 597-82-0 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: Testing proposal is based on concern identified by the registrant.” 03/02/2016 21/03/2016 Details
O,O,O-triphenyl phosphorothioate 209-909-9 597-82-0 Sub-chronic toxicity (90-day): oral 16/12/2016 30/01/2017 Details
Bis[2-[2-(1-methylethyl)-3-oxazolidinyl]ethyl] hexan-1,2-diylbiscarbamate 261-879-6 59719-67-4 Genetic toxicity in vivo 01/07/2021 16/08/2021 Details
Bis[2-[2-(1-methylethyl)-3-oxazolidinyl]ethyl] hexan-1,2-diylbiscarbamate 261-879-6 59719-67-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
30/06/2014
30/06/2014
 Details
Manganese carbonate 209-942-9 598-62-9 Reproductive toxicity (pre-natal developmental toxicity) 26/08/2021 11/10/2021 Details
(R)-p-mentha-1,8-diene 227-813-5 5989-27-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/05/2020 09/07/2020 Details
N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-methyl-prop-2-enamide 611-915-5 59941-98-9 Genetic toxicity in vivo 22/04/2021 07/06/2021 Details
Propanol, oxybis-, polymer with 1,1'-methylenebis[4-isocyanatobenzene] 701-040-8 59952-43-1 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) 01/04/2022 16/05/2022 Details
Edetic acid 200-449-4 60-00-4 Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with_Na2H2EDTA (identifier not available) 16/06/2011 01/08/2011 Details
2-phenylethanol 200-456-2 60-12-8 Reproductive toxicity (two-generation reproductive toxicity) 15/04/2014 30/05/2014 Details
2-mercaptoethanol 200-464-6 60-24-2 Reproductive toxicity (pre-natal developmental toxicity) 15/04/2011 30/05/2011 Details
diethyl ether 200-467-2 60-29-7 Reproductive toxicity (two-generation reproductive toxicity) 15/07/2011 29/08/2011 Details
Diethyl ether 200-467-2 60-29-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 02/11/2018 17/12/2018 Details
3,3-bis[(dimethylvinylsilyl)oxy]-1,1,5,5-tetramethyl-1,5-divinyltrisiloxane 262-061-1 60111-54-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/10/2014
16/10/2014
01/12/2014
01/12/2014
 Details
Triphenylphosphine 210-036-0 603-35-0 Long-term toxicity to fish 03/10/2023 17/11/2023 Details
1-chloro-2,3-dimethylbenzene 480-880-4 608-23-1 Reproductive toxicity (pre-natal developmental toxicity) 10/08/2018 24/09/2018 Details
1,6-Bis-[(2,2-dimethyl-3-lauroyloxy-propylidene)-amino]hexane 479-930-8 613222-52-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
30/06/2014
30/06/2014
 Details
tert-butyl perbenzoate 210-382-2 614-45-9
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
16/06/2011
16/06/2011
01/08/2011
01/08/2011
 Details
tert-butyl perbenzoate 210-382-2 614-45-9 Long-term toxicity to fish 23/03/2020 07/05/2020 Details
1-methylimidazole 210-484-7 616-47-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2014
15/04/2014
30/05/2014
30/05/2014
 Details
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt 262-872-0 61617-00-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/04/2014
15/04/2014
30/05/2014
30/05/2014
 Details
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4)
31/01/2018
31/01/2018
19/03/2018
19/03/2018

Details
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (EC 219-137-4) 25/05/2020 09/07/2020 Details
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9)
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9)
04/10/2013
04/10/2013
18/11/2013
18/11/2013
 Details
Resin acids and Rosin acids, potassium salts 263-142-4 61790-50-9
Reproductive toxicity (pre-natal developmental toxicity)|| Note: Testing proposed with Rosin (CAS 8050-09-7)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Rosin (CAS 8050-09-7)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin (CAS 8050-09-7); Rosin, hydrogenated (CAS 65997-06-0); and Rosin, reaction products with formaldehyde (CAS 91081-53-7)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
 Details
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