Predchádzajúce/výsledok
Predchádzajúce/výsledok
Predchádzajúce/výsledok
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
Polysulfides, di-tert-dodecyl | 270-335-7 | 68425-15-0 | Bioaccumulation aquatic / sediment | 16/02/2015 | 02/04/2015 | Details | |
Polysulfides, di-tert-Bu | 273-103-3 | 68937-96-2 | Bioaccumulation aquatic / sediment | 01/07/2011 | 15/08/2011 | Details | |
Polysulfides, bis[3-(triethoxysilyl)propyl] | 915-673-4 | - | Sub-chronic toxicity (90-day): oral | 21/10/2021 | 07/12/2021 | Details | |
Polysulfides, bis[3-(triethoxysilyl)propyl] | 915-673-4 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
Polysulfides, bis[3-(triethoxysilyl)propyl] | 915-673-4 | - |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
Polysulfides, bis[3-(triethoxysilyl)propyl] | 915-673-4 | - | Reproductive/developmental toxicity | 22/12/2010 | 07/02/2011 | Details | |
Polyphosphoric acids, esters with triethanolamine, sodium salts | 268-625-3 | 68131-72-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
Polyamide wax | 434-430-9 | - | Long-term toxicity to fish | 07/07/2020 | 21/08/2020 | Details | |
Poly[oxy(methyl-1,2-ethanediyl)], α,α'-(2,2-dimethyl-1,3-propanediyl)bis[ω-hydroxy-] | 610-848-9 | 52479-58-0 | Sub-chronic toxicity (90-day): oral | 18/09/2014 | 03/11/2014 | Details | |
Poly[oxy(methyl-1,2-ethanediyl)], a-hydro-omega-hydroxy-, ether with 2,6 bis{[(2-hydroxyethyl)amino]methyl}-4-nonylphenol | 614-668-1 | 68610-97-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/09/2015 30/09/2015 |
16/11/2015 16/11/2015 |
Details | |
Poly[oxy(methyl-1,2-ethanediyl)], .alapha.,α'-(2,2-dimethyl-1,3-propanediyl)bis[ω-[(1-oxo-2-propenyl)oxy | 701-440-2 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/10/2022 26/10/2022 |
12/12/2022 12/12/2022 |
Details | |
Poly-(1,4-diisopropylbenzol) | 449-400-0 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- | 500-012-0 | 9004-77-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1). Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
Poly(oxy-1,2-ethanediyl), .alpha.-[3-[(carboxymethyl)methylamino]-2-hydroxypropyl]-.omega.-(4-nonylphenoxy)-, monosodium sal | 616-248-3 | 75627-31-5 |
Reproductive toxicity (pre-natal developmental toxicity Sub-chronic toxicity (90-day): oral |
23/12/2015 23/12/2015 |
03/02/2016 03/02/2016 |
Details | |
Poly(alkan-2-yl)heteropolycycle | - | - | Genetic toxicity in vivo | 31/01/2013 | 18/03/2013 | Details | |
Poly [oxy(methyl-1,2-ethanediyl)] , a -hydro-w -hydroxy-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1), 3-[[3-dimethylamino) propyl]imino]butanoate | 613-645-3 | 646505-36-4 | Reproductive toxicity (pre-natal developmental toxicity) | 15/07/2014 | 29/08/2014 | Details | |
Polar modified Rice Bran Wax | - | - | Reproductive toxicity (pre-natal developmental toxicity) | 03/05/2023 | 19/06/2023 | Details | |
Pleuromulin | 204-747-5 | 125-65-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
06/09/2018 06/09/2018 06/09/2018 |
22/10/2018 22/10/2018 22/10/2018 |
Details | |
Platinum, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane complexes | 701-315-2 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
platinum(IV) nitrate/nitric acid solution | 432-400-1 | - | Genetic toxicity in vivo | 26/08/2021 | 11/10/2021 | Details | |
Platinum(IV) aqua hydroxo nitrato complexes | 701-319-4 | - | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
plastic, waste, pyrolized, fractionation bottoms (raw diesel) | 942-177-5 | - | Genetic toxicity in vivo | 10/05/2022 | 27/06/2022 | Details | |
Pivalic acid | 200-922-5 | 75-98-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
20/12/2017 20/12/2017 20/12/2017 |
05/02/2018 05/02/2018 05/02/2018 |
Details | |
Phthalic anhydride | 201-607-5 | 85-44-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
18/03/2021 18/03/2021 |
03/05/2021 03/05/2021 |
Details | |
Phthalic acid | 201-873-2 | 88-99-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with phthalic anhydride (EC no. 201-607-5) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with phthalic anhydride (EC no. 201-607-5) |
21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 |
Details | |
Phosphorous acid, tri-C12-14-alkyl esters | 297-701-9 | 93686-48-7 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) |
16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts | 272-238-5 | 68784-31-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts | 272-238-5 | 68784-31-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with another ZDDP read-across category member depending on the outcome of the other testing proposals Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts | 270-608-0 | 68457-79-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with the substance, with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts | 270-608-0 | 68457-79-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
01/09/2016 01/09/2016 01/09/2016 |
17/10/2016 17/10/2016 17/10/2016 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts | 272-723-1 | 68909-93-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts | 272-723-1 | 68909-93-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Sub-chronic toxicity (90-day): oral || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu) esters, zinc salts | 270-478-5 | 68442-22-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) and another relevant read-across member of the ZDDP category Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu) esters, zinc salts | 270-478-5 | 68442-22-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts | 273-527-9 | 68988-45-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with a read-across member of the ZDDP category(identity of test material not yet decided) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts | 273-527-9 | 68988-45-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts | 288-917-4 | 85940-28-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with a read-across member of the ZDDP category Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts | 288-917-4 | 85940-28-9 |
"Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) ""Testing proposed according to a plan for the ZDDP category.“
" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts | 283-392-8 | 84605-29-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) and another read-across member from ZDDP category Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts | 283-392-8 | 84605-29-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphoric acid, octadecyl ester | 254-466-7 | 39471-52-8 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/04/2015 17/04/2015 17/04/2015 17/04/2015 |
04/06/2015 04/06/2015 04/06/2015 04/06/2015 |
Details | |
Phosphoric acid, mixed esters with Bu alc. and ethylene glycol | 284-716-0 | 84962-20-9 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1 Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1 |
20/05/2015 20/05/2015 |
06/07/2015 06/07/2015 |
Details | |
Phosphoric acid, dodecyl ester, potassium salt | 254-414-3 | 39322-78-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
Phosphoric acid, C11-14 (C13-rich)-isoalkyl mono- and di-esters, partially salted with 1-Propanamine, 3-(tridecyloxy)-, branched | 947-480-6 | - | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant | 19/10/2020 | 03/12/2020 | Details | |
Phosphoric acid, butyl ester | 235-826-2 | 12788-93-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/04/2015 17/04/2015 |
04/06/2015 04/06/2015 |
Details | |
Phosphoric acid, 2-ethylhexyl ester | 235-741-0 | 12645-31-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1), reaction products with 1-tetradecanamine and urea | 436-230-7 | 359406-89-6 | Sub-chronic toxicity (90-day): oral | 06/03/2012 | 20/04/2012 | Details | |
Phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxide | 423-340-5 | 162881-26-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
22/12/2010 22/12/2010 22/12/2010 |
07/02/2011 07/02/2011 07/02/2011 |
Details | |
Phenol, methylstyrenated | 270-966-8 | 68512-30-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 |
Details | |
Phenol, isopropylated, phosphate (3:1) | 273-066-3 | 68937-41-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
Phenol, isopropylated, phosphate (3:1) | 273-066-3 | 68937-41-7 |
Bioaccumulation aquatic / sediment Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
29/07/2011 29/07/2011 29/07/2011 29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 12/09/2011 12/09/2011 12/09/2011 |
Details | |
Phenol, isopropylated, phosphate (3:1) | 273-066-3 | 68937-41-7 | Reproductive toxicity (pre-natal developmental toxicity) | 30/06/2023 | 14/08/2023 | Details | |
Phenol, 4,4'-(1-methylethylidene)bis-, oligomeric reaction products with 2-(chloromethyl)oxirane, reaction products with 1,3-benzenedimethanamine | 500-302-7 | 113930-69-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
Phenol, 2-methoxy-, reaction products with 2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane, hydrogenated | 275-062-7 | 70955-71-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/08/2021 | 11/10/2021 | Details | |
Petroleum diesel/gas oil fraction, co-processed with renewable hydrocarbons derived from thermally cracked plastics | 941-803-4 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9)
||Note: testing proposed with Fuels, diesel (EC no. 269-822-7)
||Note: testing proposed with Fuel oil, no. 4 (EC no. 270-673-5)
||Note: testing proposed with Distillates (petroleum), light hydrocracked (EC no. 265-078-2) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Gas oils (petroleum), light vacuum (EC no. 265-059-9) |
26/10/2022 26/10/2022 26/10/2022 |
12/12/2022 12/12/2022 12/12/2022 |
Details | |
Peroxyacetic acid, reaction products with N2,N2’-1,6-hexanediylbis[N4,N6-dibutyl-N2,N4,N6-tris(2,2,6,6,tetramethyl-4-piperidinyl)-1,3,5-triazine-2,4,6-triamine, hydrogenated | 812-927-5 | 1902936-62-2 | Reproductive toxicity (pre-natal developmental toxicity) | 10/08/2018 | 24/09/2018 | Details | |
Perfluoroethane | 200-939-8 | 76-16-4 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation |
14/08/2014 14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 28/09/2014 |
Details | |
Perfluamine | 206-420-2 | 338-83-0 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Perfluamine | 206-420-2 | 338-83-0 |
Genetic toxicity in vivo (In vivo Mammalian Alkaline Comet Assay) Genetic toxicity in vivo (Mammalian Erythrocyte Micronucleus Test) Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
29/03/2019 29/03/2019 29/03/2019 29/03/2019 |
13/05/2019 13/05/2019 13/05/2019 13/05/2019 |
Details | |
Peracetic acid | 201-186-8 | 79-21-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/08/2021 26/08/2021 |
11/10/2021 11/10/2021 |
Details | |
Pentyl 2-cyano-(3-(6-methoxybenzothiazol-2-ylimino)-2,3-dihydro-1H-isoindol-1-ylidene)acetate | 436-060-3 | - | Genetic toxicity in vivo | 26/10/2022 | 12/12/2022 | Details | |
Pentasodium triphosphate | 231-838-7 | 7758-29-4 | Sub-chronic toxicity (90-day) via the inhalatory route (rat) | 08/04/2010 | 24/05/2010 | Details | |
pentasodium 5-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}-3-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-4-hydroxynaphthalene-2,7-disulfonate | 402-420-3 | 89157-03-9 | Sub-chronic toxicity (90-day): oral | 25/06/2019 | 09/08/2019 | Details | |
pentasodium 4-amino-3-[{4-[(2,4-disulfonatophenyl)diazenyl]-3-methylphenyl}diazenyl]-5-hydroxy-6-[(4-nitro-2-sulfonatophenyl)diazenyl]naphthalene-1,7-disulfonate | 948-569-2 | - | Genetic toxicity in vivo | 01/04/2022 | 16/05/2022 | Details | |
Pentane-2,4-dione | 204-634-0 | 123-54-6 |
Long-term toxicity to fish Reproductive toxicity (two-generation reproductive toxicity) |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
Pentane-1,2-diol | 226-285-3 | 5343-92-0 | Sub-chronic toxicity (90-day): oral | 16/06/2011 | 01/08/2011 | Details | |
Pentan-3-one | 202-490-3 | 96-22-0 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2011 | 29/08/2011 | Details | |
Pentan-2-one | 203-528-1 | 107-87-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
Pentaerythritol, reaction product with fatty acids, C8 to 18 (even numbered) and/or branched and/or unsaturated | 484-420-3 | - | Reproductive toxicity (pre-natal developmental toxicity) | 30/04/2012 | 14/06/2012 | Details | |
Pentaerythritol tetrakis(3-mercaptopropionate) | 231-472-8 | 7575-23-7 | Long-term toxicity to fish | 01/07/2021 | 16/08/2021 | Details | |
Pentaerythritol tetrakis(3-mercaptopropionate) | 231-472-8 | 7575-23-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
01/07/2011 01/07/2011 01/07/2011 |
15/08/2011 15/08/2011 15/08/2011 |
Details | |
Pentaerythritol | 204-104-9 | 115-77-5 | Long-term toxicity to fish | 03/05/2023 | 19/06/2023 | Details | |
pentaerythritol | 204-104-9 | 115-77-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
20/12/2017 20/12/2017 |
05/02/2018 05/02/2018 |
Details | |
Paraffins (petroleum), normal C>10 | 265-232-9 | 64771-71-7 | Reproductive toxicity (two-generation reproductive toxicity) | 15/09/2011 | 31/10/2011 | Details | |
p-xylene | 203-396-5 | 106-42-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 18/02/2021 | 05/04/2021 | Details | |
p-tert-butylstyrene | 217-126-9 | 1746-23-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
p-tert-butylphenyl 1-(2,3-epoxy)propyl ether | 221-453-2 | 3101-60-8 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2014 17/06/2014 17/06/2014 17/06/2014 |
01/08/2014 01/08/2014 01/08/2014 01/08/2014 |
Details | |
p-phenylenediammine | 203-404-7 | 106-50-3 | Long-term toxicity testing to fish | 26/01/2011 | 14/03/2011 | Details | |
p-cresol | 203-398-6 | 106-44-5 | Long-term toxicity to fish | 10/05/2022 | 27/06/2022 | Details | |
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline | 225-716-2 | 5026-74-4 |
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) |
15/07/2014 15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 29/08/2014 |
Details | |
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline | 225-716-2 | 5026-74-4 |
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5) |
15/07/2014 15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 29/08/2014 |
Details | |
Oxydipropyl dibenzoate | 248-258-5 | 27138-31-4 | Long-term toxicity to fish | 10/08/2018 | 24/09/2018 | Details | |
Oxalaldehyde | 203-474-9 | 107-22-2 |
Chronic toxicity / carcinogenicity Reproductive toxicity (two-generation reproductive toxicity) |
05/04/2011 05/04/2011 |
20/05/2011 20/05/2011 |
Details | |
Orthoboric acid, compound with 2-aminoethanol | 247-421-8 | 26038-87-9 |
Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/09/2011 15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 31/10/2011 |
Details | |
Orthoboric acid, compound with 2-aminoethanol | 247-421-8 | 26038-87-9 | Repeated dose toxicity (90-day): oral | 17/11/2011 | 02/01/2012 | Details | |
orthoboric acid, compound with 2,2'-iminodiethanol | 267-886-0 | 67952-33-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with MEA Polyborate Sub-chronic toxicity (90-day): oral || Note: testing proposed with MEA Polyborate |
30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 |
Details | |
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate | 252-029-5 | 34443-12-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
21/01/2021 21/01/2021 |
08/03/2021 08/03/2021 |
Details | |
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate | 252-029-5 | 34443-12-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/03/2014 21/03/2014 21/03/2014 |
05/05/2014 05/05/2014 05/05/2014 |
Details | |
OO-tert-butyl monoperoxymaleate | 217-691-1 | 1931-62-0 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
Oligomerisation reaction products of glyoxal and urea | 610-945-6 | 53037-34-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
Oleic acid, compound with (Z)-N-octadec-9-enylpropane-1,3-diamine (2:1) | 251-846-4 | 34140-91-5 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
octyltrichlorosilane | 226-112-1 | 5283-66-9 | Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) | 25/06/2015 | 10/08/2015 | Details | |
Octylphosphonic acid | 225-218-5 | 4724-48-5 | Reproductive toxicity (pre-natal developmental toxicity) | 16/05/2014 | 30/06/2014 | Details | |
Octylphosphonic acid | 225-218-5 | 4724-48-5 | Sub-chronic toxicity (90-day): oral | 03/04/2023 | 22/05/2023 | Details | |
Octyl octanoate | 218-980-5 | 2306-88-9 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
03/04/2023 03/04/2023 03/04/2023 |
22/05/2023 22/05/2023 22/05/2023 |
Details | |
Octene, hydroformylation products, low-boiling | 273-110-1 | 68938-03-4 | Genetic toxicity in vivo | 17/06/2014 | 01/08/2014 | Details | |
Octene, hydroformylation products, low-boiling | 273-110-1 | 68938-03-4 | Reproductive toxicity (pre-natal developmental toxicity) | 23/11/2020 | 07/01/2021 | Details | |
Octene, hydroformylation products, high-boiling | 271-237-7 | 68526-89-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 23/04/2018 | 07/06/2018 | Details | |
Octene, hydroformylation products, high-boiling | 271-237-7 | 68526-89-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 29/08/2011 |
Details | |
Octene | 246-920-8 | 25377-83-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with hex-1-ene Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 |
Details | |