Preskoč na obsah
Preskoč na obsah

Predchádzajúce/výsledok

Predchádzajúce/výsledok

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 
Isodecyl diphenyl phosphate 249-828-6 29761-21-5 Bioaccumulation aquatic / sediment 15/07/2011 29/08/2011
Isooctyl acrylate 249-707-8 29590-42-9
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/03/2011
15/03/2011
29/04/2011
29/04/2011
Triethoxyoctylsilane 220-941-2 2943-75-1 Long-term toxicity to fish || Note: testing proposed with Triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1) 17/04/2015 04/06/2015
Triethoxyoctylsilane 220-941-2 2943-75-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
methyl-1h-benzotriazole 249-596-6 29385-43-1 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with either Benzotriazole, Tolyltriazole, Sodium Benzotriazolate, or Sodium Tolyltriazolate 16/12/2016 30/01/2017
[3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane 220-780-8 2897-60-1 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 16/12/2016 30/01/2017
2,2,6,6-tetramethyl-4-oxopiperidinooxy 220-778-7 2896-70-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2)
14/08/2014
14/08/2014
28/09/2014
28/09/2014
4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline] 249-204-3 28768-32-3
Reproduction toxicity (two generation reproductive toxicity)
Reproductive toxicity (developmental toxicity)
Sub-chronic toxicity (90-day): dermal
26/01/2011
26/01/2011
26/01/2011
14/03/2011
14/03/2011
14/03/2011
N-(1,1-dimethyl-3-oxobutyl)acrylamide 220-713-2 2873-97-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
Zinc bis(O,O-diisooctyl) bis(dithiophosphate) 249-109-7 28629-66-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Diisodecyl sebacate 249-047-0 28473-19-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
17/07/2014
17/07/2014
1,4-diazabicyclooctane 205-999-9 280-57-9 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
Benzyltoluene 248-654-8 27776-01-8 Long-term toxicity to fish (OECD 210) 25/06/2019 09/08/2019
Benzyltoluene 248-654-8 27776-01-8 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2014 04/04/2014
Isotridecan-1-ol 248-469-2 27458-92-0 Reproductive toxicity (pre-natal developmental toxicity) 20/12/2017 05/02/2018
2-ethylhexyl nitrate 248-363-6 27247-96-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
29/04/2011
29/04/2011
29/04/2011
14/06/2011
14/06/2011
14/06/2011
Nonene 248-339-5 27215-95-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
25/06/2012
15/07/2011
15/07/2011
09/08/2012
Oxydipropyl dibenzoate 248-258-5 27138-31-4 Long-term toxicity to fish 10/08/2018 24/09/2018
α,α,α',α'-tetramethylxylene-α,α-diol 248-256-4 27138-01-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 248-227-6 27107-89-7 Genetic toxicity in vivo 30/11/2015 14/01/2016
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 248-227-6 27107-89-7
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2011
16/05/2011
16/05/2011
30/06/2011
30/06/2011
30/06/2011
Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea 500-057-6 27104-30-9 Sub-chronic toxicity (90-day): oral 02/09/2011 17/10/2011
Octadecene 248-205-6 27070-58-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
31/05/2011
31/05/2011
15/07/2011
15/07/2011
Hexadecene 248-131-4 26952-14-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
25/06/2012
15/07/2011
15/07/2011
09/08/2012
Tetradecene 248-130-9 26952-13-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
31/05/2011
31/05/2011
15/07/2011
15/07/2011
Tricyclodecanedimethanol 248-096-5 26896-48-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
30/09/2011
30/09/2011
N-ethyl-2-pyrrolidone (NEP) 220-250-6 2687-91-4
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day) via the inhalatory route
26/01/2011
26/01/2011
14/03/2011
14/03/2011
Diisopropylbenzene hydroperoxide 247-988-1 26762-93-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): dermal
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5
Reproductive toxicity (developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day)
26/05/2010
26/05/2010
26/05/2010
12/07/2010
12/07/2010
12/07/2010
tert-butyl peroxyneodecanoate 247-955-1 26748-41-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/06/2014
17/06/2014
01/08/2014
01/08/2014
Zinc bis[O-(2-ethylhexyl)] bis[O-(isobutyl)] bis(dithiophosphate) 247-810-2 26566-95-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
19/11/2018
19/11/2018
Dihexadecyl peroxodicarbonate 247-611-0 26322-14-5
Reproductive toxicity (pre-natal developmental toxicity) || Note: Name of the substance on which testing is proposed to be carried out: ditetradecyl peroxydicarbonate (EC: 258-436-4)
Sub-chronic toxicity (90-day): oral
23/04/2018
23/04/2018
07/06/2018
07/06/2018
1,1,3,3-tetramethyl-1,3-divinyldisiloxane 220-099-6 2627-95-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Bis(2-ethylhexyl) tetrabromophthalate 247-426-5 26040-51-7 Reproductive toxicity (pre-natal developmental toxicity) 16/05/2014 30/06/2014
Orthoboric acid, compound with 2-aminoethanol 247-421-8 26038-87-9 Repeated dose toxicity (90-day): oral 17/11/2011 02/01/2012
Orthoboric acid, compound with 2-aminoethanol 247-421-8 26038-87-9
Long-term or reproductive toxicity to birds
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine 426-040-2 25713-60-4
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2011
16/06/2011
16/06/2011
16/06/2011
01/08/2011
01/08/2011
01/08/2011
01/08/2011
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane 219-863-1 2554-06-5
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
03/03/2014
03/03/2014
03/03/2014
03/03/2014
17/04/2014
17/04/2014
17/04/2014
17/04/2014
4-phenylbutan-2-one 219-847-4 2550-26-7 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a read-across substance having similar formula structure and its carbon chain consists of even number of carbons 22/11/2017 08/01/2018
Triethoxypropylsilane 219-842-7 2550-02-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
03/03/2014
03/03/2014
17/04/2014
17/04/2014
Dodecene 246-922-9 25378-22-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
31/05/2011
31/05/2011
15/07/2011
15/07/2011
Octene 246-920-8 25377-83-7
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with hex-1-ene
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
17/07/2014
17/07/2014
Tridecene 246-919-2 25377-82-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
31/05/2011
31/05/2011
15/07/2011
15/07/2011
Decene 246-870-7 25339-53-1
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
25/06/2012
15/07/2011
15/07/2011
09/08/2012
2,2'-(octadec-9-enylimino)bisethanol 246-807-3 25307-17-9 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
2,2`-(octadec-9-enylimino)bisethanol 246-807-3 25307-17-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): inhalation
15/04/2011
15/04/2011
30/05/2011
30/05/2011
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
01/09/2017
01/09/2017
16/10/2017
16/10/2017
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0 Reproductive toxicity (pre-natal developmental toxicity) 26/04/2019 10/06/2019
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane 219-784-2 2530-83-8 Genetic toxicity in vivo 01/08/2012 17/09/2012
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane 219-784-2 2530-83-8 Genetic toxicity in vivo 16/02/2015 02/04/2015
Tetrapropylenebenzene 246-772-4 25265-78-5
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
31/10/2011
31/10/2011
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol 246-771-9 25265-77-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/04/2019
26/04/2019
26/04/2019
10/06/2019
10/06/2019
10/06/2019
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol 246-771-9 25265-77-4 Reproductive toxicity (pre-natal developmental toxicity) 16/06/2011 01/08/2011
3-(trimethoxysilyl)propiononitrile 219-764-3 2526-62-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/03/2014
21/03/2014
05/05/2014
05/05/2014
Ethylenediamine, propoxylated 500-035-6 25214-63-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
10/06/2019
10/06/2019
2,4,4-trimethylpentene 246-690-9 25167-70-8
Reproductive toxicity (pre-natal developmental toxicity) || Note: There are two testing proposals for this endpoint.
Sub-chronic toxicity (90-day): oral
26/03/2018
26/03/2018
11/05/2018
11/05/2018
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 246-678-3 25155-25-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 27/05/2019 11/07/2019
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 246-678-3 25155-25-3 Reproductive toxicity (pre-natal developmental toxicity) 30/11/2015 14/01/2016
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 246-678-3 25155-25-3
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
06/03/2012
06/03/2012
06/03/2012
20/04/2012
20/04/2012
20/04/2012
Trixylyl phosphate 246-677-8 25155-23-1 Bioaccumulation aquatic / sediment 02/09/2011 17/10/2011
tert-dodecanethiol 246-619-1 25103-58-6 Sub-chronic toxicity (90 day): inhalation 14/11/2013 30/12/2013
tert-dodecanethiol 246-619-1 25103-58-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/06/2017
22/06/2017
07/08/2017
07/08/2017
triethoxy(3-isocyanatopropyl)silane 246-467-6 24801-88-5 Genetic toxicity in vivo

Note: testing proposed with 3-(Trimethoxysilyl)propyl isocyanate (EC 239-415-9)
03/02/2016 21/03/2016
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) 219-514-3 2451-62-9 Reproductive toxicity (two-generation reproductive toxicity) 19/11/2010 03/01/2011
2-(2H-benzotriazol-2-yl)-p-cresol 219-470-5 2440-22-4 Bioaccumulation aquatic / sediment 18/06/2018 02/08/2018
11-aminoundecanoic acid 219-417-6 2432-99-7 Reproductive toxicity (developmental toxicity) 08/04/2010 24/05/2010
1,4-bis(2,3-epoxypropoxy)butane 219-371-7 2425-79-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): most appropriate route
14/02/2011
14/02/2011
14/02/2011
31/03/2011
31/03/2011
31/03/2011
2-Hexyldecan-1-ol 219-370-1 2425-77-6 Reproductive toxicity (two-generation reproductive toxicity) 05/04/2011 20/05/2011
6-(isononanoylamino)hexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:1) 701-138-0 242482-67-3 Reproductive toxicity (pre-natal developmental toxicity) 01/09/2017 16/10/2017
Benzophenone-3,3':4,4'-tetracarboxylic dianhydride 219-348-1 2421-28-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
1,1'-dithiobis[hexahydro-2H-azepin-2-one] 245-910-0 23847-08-7 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015
[3-(triethoxysilyl)propyl]urea 245-876-7 23779-32-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/04/2015
17/04/2015
04/06/2015
04/06/2015
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4 2370-88-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4 2370-88-9
Sub-chronic toxicity (90-day): oral
-
22/11/2017
22/11/2017
08/01/2018
08/01/2017
Methyl [3-(trimethoxysilyl)propyl]carbamate 245-659-7 23432-62-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/03/2017
10/03/2017
10/03/2017
25/04/2017
25/04/2017
25/04/2017
N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine 245-642-4 23410-40-4
Reproductive toxicity (pre-natal developmental toxicity)
Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6)
Sub-chronic toxicity (90-day): oral
Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] 245-509-0 23235-61-2 Sub-chronic toxicity (90-day): oral 30/09/2015 16/11/2015
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] 245-509-0 23235-61-2 Reproductive toxicity (developmental toxicity) 26/01/2011 14/03/2011
2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] 245-509-0 23235-61-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide 218-915-0 2280-49-1
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Tetraammonium ethylenediaminetetraacetate 245-022-3 22473-78-5 Sub-chronic toxicity (90 day): inhalation 16/06/2011 01/08/2011
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate 244-894-2 22288-43-3 Reproductive toxicity (pre-natal developmental toxicity) 03/03/2014 17/04/2014
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl 218-760-9 2226-96-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl 218-760-9 2226-96-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/02/2015
16/02/2015
02/04/2015
02/04/2015
butan-2-one O,O',O''-(vinylsilylidyne)trioxime 218-747-8 2224-33-1 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Butan-2-one O,O',O''-(methylsilylidyne)trioxime (CAS 22984-54-9).
25/06/2015 10/08/2015
Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) 218-679-9 2215-35-2
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 218-664-7 2212-81-9
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant
20/10/2016
20/10/2016
05/12/2016
05/12/2016
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 218-664-7 2212-81-9
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2012
16/05/2012
16/05/2012
02/07/2012
02/07/2012
02/07/2012
2,3-epoxypropyl o-tolyl ether 218-645-3 2210-79-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
12-hydroxyoctadecanoic acid, reaction products with 1,3-benzenedimethanamine and hexamethylenediamine 432-840-2 220926-97-6 Repeated dose toxicity: Inhalation 04/05/2010 18/06/2010
S-(3-(triethoxysilyl)propyl)octanethioate 436-690-9 220727-26-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
25/09/2012
25/09/2012
25/09/2012
12/11/2012
12/11/2012
12/11/2012
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene] 244-617-5 21850-44-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
18/09/2014
18/09/2014
03/11/2014
03/11/2014
4-((Triethoxysilyl)methyl) morpholine 480-370-1 21743-27-1
Reproductive toxicity (developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day)
27/11/2009
27/11/2009
27/11/2009
11/01/2010
11/01/2010
11/01/2010
tin monoxide 244-499-5 21651-19-4 Sub-chronic toxicity (90 day): inhalation 23/01/2015 09/03/2015
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide 806-543-7 215917-77-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 30/11/2015 14/01/2016
Vinyl laurate 218-414-7 2146-71-6 Sub-chronic toxicity (90-day): oral 16/05/2011 30/06/2011
N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide 435-860-1 214417-91-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/04/2012
17/04/2012
01/06/2012
01/06/2012
2-[(2-methyl-1-oxoallyl)oxy]ethyl acetoacetate 244-311-1 21282-97-3 Genetic toxicity in vivo 29/04/2014 13/06/2014
Fatty acids, C16-C18 and C18-unsatd., ME esters, epoxidized, reaction products with ethylen glycol 606-712-3 211450-54-3 Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014
Cobalt dihydroxide 244-166-4 21041-93-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Diammonium dihydrogen ethylenediaminetetraacetate 244-063-4 20824-56-0 Sub-chronic toxicity (90 day): inhalation 29/07/2011 12/09/2011
8,9,10,11-tetrachloro-12H-phthaloperin-12-one 244-007-9 20749-68-2 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
Disilver oxide 243-957-1 20667-12-3 Sub-chronic toxicity (90-day): oral 15/04/2011 30/05/2011
Tetraammineplatinum dinitrate 243-929-9 20634-12-2 Genetic toxicity in vivo || Note: testing proposed with tetraammineplatinum(II) dichloride. Testing proposal is based on concern identified by the registrant. 28/02/2018 16/04/2018
triethoxy(methyl)silane 217-983-9 2031-67-6 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with trimethoxy(methyl)silane. 16/10/2014 01/12/2014
Sodium 4-oxovalerate 243-378-4 19856-23-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/06/2018
18/06/2018
02/08/2018
02/08/2018
Methanal, reaction products with 1,3-bis(aminomethyl)benzene and hydroxybenzen 701-207-5 1950616-36-0
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/05/2018
21/05/2018
21/05/2018
05/07/2018
05/07/2018
05/07/2018
Hexahydro-4-methylphthalic anhydride 243-072-0 19438-60-9 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018
3,3,4,4,5,5,6,6,6-nonafluorohexene 243-053-7 19430-93-4 Sub-chronic toxicity (90 day): inhalation 14/08/2014 28/09/2014
benzyl butyl cis-cyclohexane-1,2-dicarboxylate 701-279-8 1931129-39-3
Long-term toxicity to fish || Note: Link to the registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5
Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5
10/12/2018
10/12/2018
10/12/2018
24/01/2019
24/01/2019
24/01/2019
reaction mass of: triphenylthiophosphate and tertiary butylated phenyl derivatives 421-820-9 192268-65-8 Reproductive toxicity (pre-natal developmental toxicity) 16/10/2014 01/12/2014
Peroxyacetic acid, reaction products with N2,N2’-1,6-hexanediylbis[N4,N6-dibutyl-N2,N4,N6-tris(2,2,6,6,tetramethyl-4-piperidinyl)-1,3,5-triazine-2,4,6-triamine, hydrogenated 812-927-5 1902936-62-2 Reproductive toxicity (pre-natal developmental toxicity) 10/08/2018 24/09/2018
1,1'-(1,1,2,2-tetramethylethylene)dibenzene 217-568-2 1889-67-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Octacos-1-ene 242-616-4 18835-34-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
31/05/2011
31/05/2011
15/07/2011
15/07/2011
Hexacos-1-ene 242-615-9 18835-33-1
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
31/05/2011
31/05/2011
15/07/2011
15/07/2011
(E)-7,11-dimethyl-3-methylenedodeca-1,6,10-triene 242-582-0 18794-84-8 Sub-chronic toxicity (90-day): oral 23/04/2018 07/06/2018
6-tert-butyl-2,4-xylenol 217-533-1 1879-09-0 Long-term toxicity to fish 15/07/2014 29/08/2014
1,1,1,3,5,5,5-heptamethyltrisiloxane 217-496-1 1873-88-7
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7
Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7.
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Fatty acids, tall-oil, reaction products with bisphenol A, epichlorohydrin, glycidyl tolyl ether and triethylenetetramine 606-078-8 186321-96-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
04/04/2014
04/04/2014
19/05/2014
19/05/2014
3-hydroxy-2-(hydroxymethyl)-2-methylpropanal 242-393-3 18516-18-2
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2011
16/06/2011
16/06/2011
16/06/2011
01/08/2011
01/08/2011
01/08/2011
01/08/2011
Strontium hydroxide 242-367-1 18480-07-4
Long-term toxicity to fish Note: testing proposed with strontium dinitrate (EC: 233-131-9, CAS: 10042-76-9)
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with strontium dinitrate (EC: 233-131-9, CAS: 10042-76-9)
Reproductive toxicity (two-generation reproductive toxicity) Note: testing proposed with strontium dinitrate (EC: 233-131-9, CAS: 10042-76-9)
15/04/2014
15/04/2014
15/04/2014
30/05/2014
30/05/2014
30/05/2014
2,6-dimethyloct-7-en-2-ol 242-362-4 18479-58-8 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
2,6-dimethyloct-7-en-2-ol 242-362-4 18479-58-8 Reproductive toxicity (two-generation reproductive toxicity) 14/02/2011 31/03/2011
Octabenzone 217-421-2 1843-05-6 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2013 04/04/2013
(3-chloropropyl)dimethoxymethylsilane 242-056-0 18171-19-2 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with (3-chloropropyl)triethoxysilane (EC 225-805-6)” 17/04/2015 04/06/2015
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane 241-867-7 17928-28-8 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8) 12/12/2014 26/01/2015
2,4,7,9-tetramethyl-4,7-decanediol 451-160-7 17913-76-7
Long-term toxicity to fish
"|| Note: testing proposed with 2,4,7,9-tetramethyldec-5-yne-4,7-diol (EC 204-809-1, CAS 126-86-3)
Reproductive toxicity (pre-natal developmental toxicity)
17/09/2019
17/09/2019
01/11/2019
01/11/2019
N-(cyclohexylthio)phthalimide 241-774-1 17796-82-6
Bioaccumulation: aquatic / sediment
Long-term or reproductive toxicity to birds
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/07/2011
01/07/2011
01/07/2011
01/07/2011
17/12/2012
15/08/2011
15/08/2011
15/08/2011
15/08/2011
31/01/2013
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one 241-753-7 17772-51-9 Reproductive toxicity (pre-natal developmental toxicity) 31/08/2015 15/10/2015
1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt 241-749-5 17766-26-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
N-(3-(trimethoxysilyl)propyl)ethylenediamine 217-164-6 1760-24-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
Aminoiminomethanesulphinic acid 217-157-8 1758-73-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/05/2014
16/05/2014
30/06/2014
30/06/2014
2-Hydroxy-5-nonyl(branched)-benzaldehyde oxime 605-717-8 174333-80-3 Long-term toxicity to fish 22/06/2017 07/08/2017
Barium hydroxide 241-234-5 17194-00-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/12/2011
16/12/2011
30/01/2012
30/01/2012
Barium hydroxide 241-234-5 17194-00-2 Long-term toxicity to fish 29/04/2011 14/06/2011
chlorodimethylvinylsilane 217-007-1 1719-58-0 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Trimethylsilanol (CAS 1066-40-6) 12/12/2014 26/01/2015
Hexachloroplatinic acid 241-010-7 16941-12-1 Genetic toxicity in vivo || Note: testing proposed with Diammonium hexachloroplatinate (EC 241-010-7). Testing proposal is based on concern identified by the registrant. 26/03/2018 11/05/2018
dipotassium heptafluorotantalate 240-986-1 16924-00-8 Genetic toxicity in vivo 16/03/2015 30/04/2015
Dipotassium hexachloroplatinate 240-979-3 16921-30-5 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 26/03/2018 11/05/2018
Diammonium hexachloroplatinate 240-973-0 16919-58-7 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 23/04/2018 07/06/2018
benzyl 3-isobutyryloxy-1-isopropyl-2,2-dimethylpropyl phthalate 240-920-1 16883-83-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/06/2011
16/06/2011
01/08/2011
01/08/2011
dimethoxymethylsilane 240-914-9 16881-77-9 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with trimethoxy(methyl)silane. 16/10/2014 01/12/2014
1,5-bis[1,2-bis(ethoxycarbonyl)ethylamino]-2-methylpentane 433-260-2 168253-59-6
Reproductive toxicity (developmental toxicity)
Sub-chronic toxicity (90-day): oral
06/09/2010
06/09/2010
20/10/2010
20/10/2010
diammonium hexanitratocerate 240-827-6 16774-21-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Cerium (III) nitrate (CAS 10294-41-4) 20/05/2015 06/07/2015
1-methyl-4-(methylsulfonyl)-2-nitrobenzene 430-550-0 1671-49-4 Genetic toxicity in vivo 16/05/2011 30/06/2011
potassium 4-cumenesulfonate 629-764-9 164524-02-1 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Sodium xylene sulphonate (EC 215-090-9) 16/12/2016 30/01/2017
potassium 4-cumenesulfonate 629-764-9 164524-02-1
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with sodium (xylenes and 4-ethylbenzene) sulphonate
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with sodium cumene sulphonate  
22/06/2017
22/06/2017
07/08/2017
07/08/2017
potassium 4-isopropylbenzenesulphonate 629-764-9 164524-02-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2015 10/08/2015
hexadecyltrimethoxysilane 240-464-3 16415-12-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/10/2014
16/10/2014
01/12/2014
01/12/2014
Reaction mass of (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran and Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran (2R,4R) and Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran (2S,4S) and (2R-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran 939-429-1 16409-43-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/11/2015
30/11/2015
14/01/2016
14/01/2016
3-(Trimethoxysilyl)propyl (2E,4E)-hexa-2,4-dienoate 642-902-2 163802-53-7 Genetic toxicity in vivo 10/03/2017 25/04/2017
Strontium carbonate 216-643-7 1633-05-2 Long-term toxicity to fish 31/05/2011 15/07/2011
Hexamethylene diisocyanate, oligomerisation product, blocked with 3,5-dimethyl-1H-pyrazole 605-318-9 163206-31-3 Sub-chronic toxicity (90 day): inhalation 12/12/2014 26/01/2015
Phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxide 423-340-5 162881-26-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
22/12/2010
22/12/2010
22/12/2010
07/02/2011
07/02/2011
07/02/2011
Condensation products of dimerised fatty acids, C18-unsaturated, with N,N-dimethyl-1,3-propanediamine and 1,3-propanediamine 605-296-0 162627-17-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): oral
14/08/2014
14/08/2014
14/08/2014
28/09/2014
28/09/2014
28/09/2014
(Z)-N-octadec-9-enylhexadecan-1-amide 240-367-6 16260-09-6 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
Tris(2,5,8,11-tetraoxatridecyl) orthoborate 310-290-3 161907-80-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
2,2-dimethyl-3-oxopropyl acetate 811-188-6 16184-79-5 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 01/09/2017 16/10/2017
Bis(2-ethylhexyl) peroxydicarbonate 240-282-4 16111-62-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2014
15/04/2014
30/05/2014
30/05/2014
Hexafluoropropene, oxidized, oligomers, reduced, fluorinated 500-537-5 161075-00-9 Bioaccumulation aquatic / sediment 16/10/2014 01/12/2014
1,6-bis(2,3-epoxypropoxy)hexane 240-260-4 16096-31-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): dermal
15/03/2011
15/03/2011
15/03/2011
29/04/2011
29/04/2011
29/04/2011
1,6-bis(2,3-epoxypropoxy)hexane 240-260-4 16096-31-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): dermal
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Fatty acids, tall oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts, consisting of mainly calcium, magnesium, zinc salts of maleated rosin, fatty acids and rosin 500-451-8 160901-14-4
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0)
Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin, Fumarated (CAS RN 65997-04-7)
Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0)
02/07/2013
02/07/2013
02/07/2013
16/08/2013
16/08/2013
16/08/2013
Fatty acids, tall-oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts 500-451-8 160901-14-4 Reproductive toxicity (pre-natal developmental toxicity) 06/03/2012 20/04/2012
Triammonium hydrogen ethylenediaminetetraacetate 240-073-8 15934-01-7 Sub-chronic toxicity (90 day): inhalation 16/06/2011 01/08/2011
Fatty acids, C16-C18 and C18-unsatd., ME esters, epoxidized 605-143-8 158318-67-3 Reproductive toxicity (pre-natal developmental toxicity) 16/05/2014 30/06/2014
Tri(isopropyl)silyl acrylate 457-670-6 157859-20-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/08/2015
31/08/2015
15/10/2015
15/10/2015
Tri(isopropyl)silyl acrylate 457-670-6 157859-20-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/08/2015
31/08/2015
15/10/2015
15/10/2015
sodium cumenesulphonate 239-854-6 15763-76-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 16/12/2016 30/01/2017
sodium p-cumenesulphonate 239-854-6 15763-76-5 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Sodium xylene sulphonate 24/04/2015 12/06/2015
Sodium p-cumenesulphonate 239-854-6 15763-76-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Sodium (xylenes and 4-ethylbenzene) sulphonate
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with sodium cumene sulphonate
22/06/2017
22/06/2017
07/08/2017
07/08/2017
bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine 239-816-9 15721-78-5
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
1,4-Benzenedicarboxylic acid, mixed Bu and 2-ethylhexyl diesters 946-149-3 1571954-81-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
21/05/2018
21/05/2018
05/07/2018
05/07/2018
Cobalt(2+) propionate 216-333-1 1560-69-6
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
Calcium cyanamide 205-861-8 156-62-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018
calcium cyanamide 205-861-8 156-62-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/04/2011
15/04/2011
30/05/2011
30/05/2011
bis(4-tert-butylcyclohexyl) peroxydicarbonate 239-557-1 15520-11-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
(chloromethyl)triethoxysilane 239-311-3 15267-95-5 Genetic toxicity in vivo 16/10/2014 01/12/2014
sodium 1H-benzotriazolide 239-269-6 15217-42-2 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 1H-Benzotriazole (EC 202-394-1) 16/12/2016 30/01/2017
1,6-Bis((dibenzylthiocarbamoyl)disulfanyl)hexane 429-280-6 151900-44-6 Reproductive toxicity (developmental toxicity) 01/09/2010 15/10/2010
Aziridine 205-793-9 151-56-4 Long-term toxicity to fish 26/01/2011 14/03/2011
a,a-dimethylphenethyl acetate 205-781-3 151-05-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/05/2017
17/05/2017
03/07/2017
03/07/2017
Mequinol 205-769-8 150-76-5 Reproductive toxicity (pre-natal developmental toxicity) 29/04/2011 14/06/2011
Dichloro(methyl)(phenyl)silane 205-746-2 149-74-6 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Trimethoxy(phenyl)silane (EC 221-066-9, CAS 2996-92-1) 04/04/2014 19/05/2014
Sodium hydroxymethanesulphinate 205-739-4 149-44-0
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
15/04/2011
30/05/2011
30/05/2011
30/05/2011
Sodium hydroxymethanesulphinate 205-739-4 149-44-0 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
bismuth oxide salicylate 238-953-1 14882-18-9 Sub-chronic toxicity (90 day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8) 18/09/2014 03/11/2014
3-(triethoxysilyl)propanethiol 238-883-1 14814-09-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/10/2014
16/10/2014
16/10/2014
01/12/2014
01/12/2014
01/12/2014
N,N-dimethyldecan-1-amide 238-405-1 14433-76-2 Long-term toxicity to fish 15/07/2011 29/08/2011
2,2,4-trimethylpentane-1,3-diol 205-619-1 144-19-4 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2014 04/04/2014
Zinc bis(diethyldithiocarbamate) 238-270-9 14324-55-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 10/08/2018 24/09/2018
Bis(2-(2-butoxyethoxy)ethoxy)methane 205-598-9 143-29-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
bis(2-(2-butoxyethoxy)ethoxy)methane 205-598-9 143-29-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/04/2011
15/04/2011
30/05/2011
30/05/2011
2-(2-(2-butoxyethoxy)ethoxy)ethanol 205-592-6 143-22-6 Reproductive toxicity (pre-natal developmental toxicity) 10/08/2018 24/09/2018
sodium/triethanolamine 4-((2-hydroxyethyl)amino)-3-pentaproenyl-4-oxobutanoate 800-765-8 1424149-03-0 Reproductive toxicity (pre-natal developmental toxicity) 15/07/2014 29/08/2014
Fatty acids, tall-oil, reaction products with fatty acids C16-C18 and C18-unsatd, branched and linear, diethylenetriamine and maleic anhydride 806-508-6 1419212-77-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral Note: testing proposed with substance Fatty acids, tall-oil, reaction products with diethylenetriamine and maleic anhydride (CAS: 1419212-76-2)
05/06/2014
05/06/2014
21/07/2014
21/07/2014
Fatty acids, tall-oil, reaction products with diethylenetriamine and maleic anhydride 800-430-6 1419212-76-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
05/06/2014
05/06/2014
21/07/2014
21/07/2014



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