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Predchádzajúce/výsledok

Predchádzajúce/výsledok

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 
Zinc bis[bis(dodecylphenyl)] bis(dithiophosphate) 259-048-8 54261-67-5
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
19/11/2018
19/11/2018


2-(2-Vinyloxyethoxy)ethyl acrylate 451-690-9 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
20/12/2017
20/12/2017
05/02/2018
05/02/2018
Melamine 203-615-4 108-78-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 17/05/2016 01/07/2016
Fatty acids, C18-unsatd., dimers, reaction products with polyethylenepolyamines 614-452-7 68410-23-1
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine
28/02/2018
28/02/2018
16/04/2018
16/04/2018
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine 500-191-5 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
28/02/2018
28/02/2018
16/04/2018
16/04/2018
O,O,O-triphenyl phosphorothioate 209-909-9 597-82-0 Sub-chronic toxicity (90-day): oral 16/12/2016 30/01/2017
cobalt dichloride 231-589-4 7646-79-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/07/2016
18/07/2016
01/09/2016
01/09/2016


sodium 1H-benzotriazolide 239-269-6 15217-42-2 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 1H-Benzotriazole (EC 202-394-1) 16/12/2016 30/01/2017
[3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane 220-780-8 2897-60-1 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 16/12/2016 30/01/2017
tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate 250-418-4 30989-05-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
29/04/2016
29/04/2016
13/06/2016
13/06/2016
Reaction mass of C18 (unsatd.) fatty acid amides/esters of diethanolamine, C16-18 (even-numbered) fatty amine (..) 943-172-0 -
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/05/2016
17/05/2016
17/05/2016
01/07/2016
01/07/2016
01/07/2016
Methylene-bis-4,1-(N-phenylene-N'-butylurea) 416-600-4 - Bioaccumulation aquatic / sediment 17/05/2016 01/07/2016
Reaction products of a polyol of pentaerythritol and propylene oxide, epichlorohydrin and hydrogen sulfide 615-735-8 72244-98-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant
Reproductive toxicity (pre-natal developmental toxicity)
11/11/2016
11/11/2016
03/01/2017
03/01/2017
1,2,4,5,7,8-Hexoxonane, 3,6,9-trimethyl-, 3,6,9-tris(Ethyl and Propyl) derivatives - - Sub-chronic toxicity (90-day): oral 30/06/2016 15/08/2016
Sodium dihydrogenorthophosphate 231-449-2 7558-80-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2016 17/10/2016
boron orthophosphate - 13308-51-5 Reproductive toxicity (pre-natal developmental toxicity) 30/06/2016 15/08/2016
2-(2-Ethoxyethoxy)-2-methylpropanee 257-196-8 51422-54-9 Sub-chronic toxicity (90 day): inhalation Reproductive toxicity (pre-natal developmental toxicity) 03/02/2016 21/03/2016
triethoxy(3-isocyanatopropyl)silane 246-467-6 24801-88-5 Genetic toxicity in vivo

Note: testing proposed with 3-(Trimethoxysilyl)propyl isocyanate (EC 239-415-9)
03/02/2016 21/03/2016
O,O,O-triphenyl phosphorothioate 209-909-9 597-82-0 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: Testing proposal is based on concern identified by the registrant.” 03/02/2016 21/03/2016
2,2'-dimethyl-2,2'-azodipropiononitrile 201-132-3 78-67-1 Reproductive toxicity (pre-natal developmental toxicity) 03/02/2016 21/03/2016
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate 401-100-0 - Sub-chronic toxicity (90-day): oral 27/05/2019 11/07/2019
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide 806-543-7 215917-77-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 30/11/2015 14/01/2016
2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol 620-540-6 1218787-32-6 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,2'-(Octadec-9-enylimino) bisethanol, CAS No 25307-17-9 14/03/2016 28/04/2016
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. 276-014-8 71786-60-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2019 09/08/2019
N,N'-dimethyldiphenylthiuram disulphide 234-196-6 10591-84-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2019
16/08/2019
30/09/2019
30/09/2019
N,N''-propane-1,3-diylbis[N'-octadecylurea 252-667-4 35674-65-8 Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) 29/03/2016 13/05/2016
2,2-dimethylpropane-1,3-diyl dibenzoate 224-081-9 4196-89-8 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016
Dichloromethylbenzene 249-854-8 29797-40-8 Reproductive toxicity (extended one-generation reproductive toxicity study) 22/06/2017 07/08/2017
3-methyldecane; benzene; cyclooctane; nonane 941-364-9 - Reproductive toxicity (extended one-generation reproductive toxicity study) 05/07/2018 20/08/2018
2,2'-[hexane-1,6-diylbis(oxymethylene)]dioxirane 618-939-5 933999-84-9 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/10/2017 11/12/2017
Amines, polyethylenepoly-, triethylenetetramine fraction,Triethylenetetramine linear, cyclic and branched 292-588-2 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/09/2017
01/09/2017
16/10/2017
16/10/2017
Amines, polyethylenepoly-, triethylenetetramine fraction 292-588-2 90640-66-7
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/11/2017
22/11/2017
08/01/2018
08/01/2018


Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene 270-128-1 68411-46-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/10/2017 11/12/2017
2,2'-(octadec-9-enylimino)bisethanol 246-807-3 25307-17-9 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
2,6-dimethyloct-7-en-2-ol 242-362-4 18479-58-8 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
Terpineol 232-268-1 8000-41-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (CAS 2370-88-9; EC 219-137-4; HD4)
31/01/2018
31/01/2018
19/03/2018
19/03/2018


2-piperazin-1-ylethylamine 205-411-0 140-31-8 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2017 16/10/2017
Geraniol 203-377-1 106-24-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/10/2017 11/12/2017
((3-(sec-butyl)-4-(decyloxy)phenyl)methanetriyl)tribenzene 801-941-7 1404190-37-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
20/10/2016
20/10/2016
05/12/2016
05/12/2016
((3-(sec-butyl)-4-(decyloxy)phenyl)methanetriyl)tribenzene 801-941-7 1404190-37-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2016
31/05/2016
15/07/2016
15/07/2016
(-)-pin-2(3)-ene 232-077-3 7785-26-4 Reproductive toxicity (pre-natal developmental toxicity) 25/10/2017 11/12/2017
(1,4-diazabicyclo[2.2.2]octane-2-yl)methanol 692-731-2 76950-43-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/02/2015
16/02/2015
02/04/2015
02/04/2015
(1-hydroxycyclohexyl) (phenyl)methanone (hydroxycyclohexyl phenyl ketone) 213-426-9 947-19-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
28/02/2011
28/02/2011
28/02/2011
14/04/2011
14/04/2011
14/04/2011
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate,Bisphenol A Diphosphate,Bisphenol A Polyphosphate 425-220-8 5945-33-5 Reproductive toxicity (two-generation reproductive toxicity) 05/04/2011 20/05/2011
(1-methylethylidene)di-4,1-phenylene tetraphenyl diphosphate,Bisphenol A Diphosphate,Bisphenol A Polyphosphate 425-220-8 5945-33-5 Sub-chronic toxicity (90-day): oral 01/09/2010 15/10/2010
(3-chloropropyl)diethoxymethylsilane 236-828-6 13501-76-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with (3-chloropropyl)triethoxysilane (CAS 5089-70-3) 17/04/2015 04/06/2015
(3-chloropropyl)dimethoxymethylsilane 242-056-0 18171-19-2 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with (3-chloropropyl)triethoxysilane (EC 225-805-6)” 17/04/2015 04/06/2015
(3E)-2-chloro-3-(hydroxymethylene)cyclohexene-1-carbaldehyde 801-656-8 1416808-92-8 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 17/04/2015 04/06/2015
(5-ethyl-1,3-dioxan-5-yl)methyl acrylate 266-380-7 66492-51-1 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014
(6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 261-491-7 58909-56-1
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/08/2018
10/08/2018
10/08/2018
24/09/2018
24/09/2018
24/09/2018
(chloromethyl)triethoxysilane 239-311-3 15267-95-5 Genetic toxicity in vivo 16/10/2014 01/12/2014
(E)-2-benzylideneoctanal 639-566-4 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/04/2011
15/04/2011
30/05/2011
30/05/2011
(E)-7,11-dimethyl-3-methylenedodeca-1,6,10-triene 242-582-0 18794-84-8 Sub-chronic toxicity (90-day): oral 23/04/2018 07/06/2018
(ethoxymethoxy)cyclododecane 261-332-1 58567-11-6 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
(no public substance name available) 434-430-9 -
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/10/2014
16/10/2014
16/10/2014
01/12/2014
01/12/2014
01/12/2014
(no public substance name available) 916-916-7 - Reproductive toxicity (pre-natal developmental toxicity) 12/12/2014 26/01/2015
(octadecanoato-O)oxoaluminium 236-521-7 13419-15-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7) 30/11/2015 14/01/2016
(phenylethyl)benzene 254-179-7 38888-98-1 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014
(Reaction product of 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol, 2-(2-hydroxyethylamino)ethanol and formaldehyde), propoxylated 926-000-9 - Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014
(Z)-4-[C11-13(branched)alkylamino]-4-oxo-2-butenoic acid 701-116-0 84583-68-6 Sub-chronic toxicity (90-day): oral || Note: The previous EC number for the substance is 283-219-6. 22/06/2017 07/08/2017
(Z)-N-octadec-9-enylhexadecan-1-amide 240-367-6 16260-09-6 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
1,1'-(1,1,2,2-tetramethylethylene)dibenzene 217-568-2 1889-67-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene] 244-617-5 21850-44-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
18/09/2014
18/09/2014
03/11/2014
03/11/2014
1,1'-(p-tolylimino)dipropan-2-ol 254-075-1 38668-48-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/03/2016
17/04/2015
28/04/2016
04/06/2015
1,1'-dithiobis[hexahydro-2H-azepin-2-one] 245-910-0 23847-08-7 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 116-37-0 Reproductive toxicity (pre-natal developmental toxicity) 31/07/2015 14/09/2015
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 116-37-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/01/2012
16/01/2012
16/01/2012
01/03/2012
01/03/2012
01/03/2012
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane 241-867-7 17928-28-8 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8) 12/12/2014 26/01/2015
1,1,1,3,5,5,5-heptamethyltrisiloxane 217-496-1 1873-88-7
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7
Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7.
25/06/2015
25/06/2015
10/08/2015
10/08/2015
1,1,3,3-tetramethyl-1,3-divinyldisiloxane 220-099-6 2627-95-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate 244-894-2 22288-43-3 Reproductive toxicity (pre-natal developmental toxicity) 03/03/2014 17/04/2014
1,1,3,3-tetramethylbutyl hydroperoxide 227-369-2 5809-08-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
1,1,3,3-tetramethylbutyl peroxyneodecanoate 257-077-0 51240-95-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
17/07/2014
17/07/2014
1,1,3,3-tetramethylbutyl peroxyneodecanoate 257-077-0 51240-95-0 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant 01/09/2017 16/10/2017
1,1,3,3-tetramethyldisiloxane 221-906-4 3277-26-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
29/04/2016
29/04/2016
13/06/2016
13/06/2016
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate) 235-935-5 13052-09-0 Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates 12/12/2014 26/01/2015
1,1`-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene 228-846-8 6362-80-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
1,2,3,4-tetrahydronaphthalene 204-340-2 119-64-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
1,2,3,4-tetrahydronaphthalene 204-340-2 119-64-2 Reproductive toxicity (two-generation reproductive toxicity) 16/06/2011 01/08/2011
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters 290-754-9 90218-76-1 Sub-chronic toxicity (90-day): oral 29/07/2011 12/09/2011
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters 271-082-5 68515-40-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/06/2011
16/06/2011
01/08/2011
01/08/2011
1,2-dihydroxybenzene,pyrocatechol 204-427-5 120-80-9
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
15/04/2011
15/04/2011
30/05/2011
30/05/2011
1,3,2-dioxathiolane 2,2-dioxide 600-809-4 1072-53-3 Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. 24/01/2019 11/03/2019
1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 213-834-7 1025-15-6 Reproductive toxicity (pre-natal developmental toxicity) 25/09/2012 12/11/2012
1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt 241-749-5 17766-26-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) 219-514-3 2451-62-9 Reproductive toxicity (two-generation reproductive toxicity) 19/11/2010 03/01/2011
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 254-996-9 40601-76-1 Reproductive toxicity (pre-natal developmental toxicity) with Rat 24/07/2019 09/09/2019
1,3- and 1,4-cyclohexandicarboxyaldehyde 482-020-3 - Reproductive toxicity (pre-natal developmental toxicity) 15/07/2014 29/08/2014
1,3-Benzenedimethanamine, N-(2-phenylethyl) derivs. 445-790-1 - Sub-chronic toxicity (90 day): inhalation 04/04/2014 19/05/2014
1,3-diethyldiphenylurea 201-645-2 85-98-3 Sub-chronic toxicity (90-day): oral 03/03/2014 17/04/2014
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione 258-904-8 53988-10-6
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3)
Reproductive toxicity (two-generation reproductive toxicity) Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3)
15/04/2014
15/04/2014
30/05/2014
30/05/2014
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt 262-872-0 61617-00-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/04/2014
15/04/2014
30/05/2014
30/05/2014
1,3-diisopropylbenzene 202-773-1 99-62-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
1,3-dimethylimidazolidin-2-one 201-304-8 80-73-9 Reproductive toxicity (two-generation reproductive toxicity) 15/04/2014 30/05/2014
1,3-dioxepane 208-015-6 505-65-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
1,3-diphenylguanidine 203-002-1 102-06-7 Long-term toxicity to fish 15/04/2011 30/05/2011
1,3-diphenylpropane-1,3-dione 204-398-9 120-46-7
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
18/09/2014
03/11/2014
03/11/2014
03/11/2014
1,4-Benzenedicarboxylic acid, mixed Bu and 2-ethylhexyl diesters 946-149-3 1571954-81-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
21/05/2018
21/05/2018
05/07/2018
05/07/2018
1,4-bis(2,3-epoxypropoxy)butane 219-371-7 2425-79-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): most appropriate route
14/02/2011
14/02/2011
14/02/2011
31/03/2011
31/03/2011
31/03/2011
1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone 255-460-7 41611-76-1 Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014
1,4-Cyclohexanedicarboxylic acid, 1,4-diisononyl ester 701-012-5 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/12/2018
10/12/2018
24/01/2019
24/01/2019
1,4-Cyclohexanedimethanol, reaction products with epichlorohydrin 600-447-7 1035218-79-1
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated
Sub-chronic toxicity (90 day): inhalation || Note: Link to registration dossier not given as the dossier not yet disseminated
23/12/2015
23/12/2015
03/02/2016
03/02/2016
1,4-diazabicyclooctane 205-999-9 280-57-9 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
1,4-diisopropylbenzene 202-826-9 100-18-5
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with CAS no. 99-62-7
Sub-chronic toxicity (90-day): oral || Note: testing proposed with CAS no. 99-62-7
18/09/2014
18/09/2014
03/11/2014
03/11/2014
1,4-phenylene bis[(4-phenoxyphenyl)-methanone] 620-097-9 54299-17-1
Bioaccumulation aquatic / sediment
Long-term toxicity to fish
22/11/2017
22/11/2017
08/01/2018
08/01/2018
1,5-bis[1,2-bis(ethoxycarbonyl)ethylamino]-2-methylpentane 433-260-2 168253-59-6
Reproductive toxicity (developmental toxicity)
Sub-chronic toxicity (90-day): oral
06/09/2010
06/09/2010
20/10/2010
20/10/2010
1,6-Bis((dibenzylthiocarbamoyl)disulfanyl)hexane 429-280-6 151900-44-6 Reproductive toxicity (developmental toxicity) 01/09/2010 15/10/2010
1,6-bis(2,3-epoxypropoxy)hexane 240-260-4 16096-31-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): dermal
15/03/2011
15/03/2011
15/03/2011
29/04/2011
29/04/2011
29/04/2011
1,6-bis(2,3-epoxypropoxy)hexane 240-260-4 16096-31-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): dermal
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
1,6-Bis-[(2,2-dimethyl-3-lauroyloxy-propylidene)-amino]hexane 479-930-8 613222-52-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
30/06/2014
30/06/2014
1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate 925-259-5 140921-24-0
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
1,8-diazabicyclo[5.4.0]undec-7-ene 229-713-7 6674-22-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
1-(2-hydroxyethyl)pyrrolidin-2-one 222-359-4 3445-11-2 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014
1-(vinyloxy)octadecane 213-208-3 930-02-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
1-[bis[3-(dimethylamino)propyl]amino]propan-2-ol 266-587-2 67151-63-7 Sub-chronic toxicity (90-day): oral 21/03/2014 05/05/2014
1-aminopropan-2-ol 201-162-7 78-96-6 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019
1-bromopropane (n-propyl bromide) 203-445-0 106-94-5 Genetic toxicity in vivo 15/04/2011 30/05/2011
1-chloro-2,3-dimethylbenzene 480-880-4 608-23-1 Reproductive toxicity (pre-natal developmental toxicity) 10/08/2018 24/09/2018
1-Dodecene, dimers 814-509-8 62132-67-6 Reproductive toxicity (pre-natal developmental toxicity) 02/11/2018 17/12/2018
1-ethynylcyclohexanol 201-100-9 78-27-3 Sub-chronic toxicity (90-day): oral 18/02/2014 04/04/2014
1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. residues 271-832-1 68609-68-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. residues 271-832-1 68609-68-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate 229-934-9 6846-50-0 Reproductive toxicity (pre-natal developmental toxicity) 14/03/2016 28/04/2016
1-isopropyl-4-methylcyclohexane 202-790-4 99-82-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
1-methyl-4-(methylsulfonyl)-2-nitrobenzene 430-550-0 1671-49-4 Genetic toxicity in vivo 16/05/2011 30/06/2011
1-methylimidazole 210-484-7 616-47-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2014
15/04/2014
30/05/2014
30/05/2014
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts 939-457-4 -
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
18/09/2014
03/11/2014
03/11/2014
03/11/2014
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts 939-455-3 -
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): oral
18/09/2014
18/09/2014
18/09/2014
03/11/2014
03/11/2014
03/11/2014
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-C12-14 acyl derivs., hydroxides, inner salts 293-878-1 91648-19-0
Long-term toxicity to fish || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-457-4)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3)
18/06/2018
18/06/2018
18/06/2018
02/08/2018
02/08/2018
02/08/2018
11-aminoundecanoic acid 219-417-6 2432-99-7 Reproductive toxicity (developmental toxicity) 08/04/2010 24/05/2010
12-hydroxyoctadecanoic acid, reaction products with 1,3-benzenedimethanamine and hexamethylenediamine 432-840-2 220926-97-6 Repeated dose toxicity: Inhalation 04/05/2010 18/06/2010
1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs. 263-171-2 61791-39-7 Bioaccumulation aquatic / sediment 16/05/2014 30/06/2014
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane 500-107-7 40039-93-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
2,2'-(cyclohexylimino)bisethanol 224-809-5 4500-29-2 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] 245-509-0 23235-61-2 Sub-chronic toxicity (90-day): oral 30/09/2015 16/11/2015
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] 245-509-0 23235-61-2 Reproductive toxicity (developmental toxicity) 26/01/2011 14/03/2011
2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] 245-509-0 23235-61-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018
2,2'-azobis[2-methylbutyronitrile] 236-740-8 13472-08-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
03/03/2014
17/04/2014
17/04/2014
17/04/2014
2,2'-azobis[2-methylpropionamidine] dihydrochloride 221-070-0 2997-92-4
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
05/07/2018
05/07/2018
20/08/2018
20/08/2018
2,2'-dimethyl-2,2'-azodipropiononitrile 201-132-3 78-67-1
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/03/2011
15/03/2011
15/03/2011
29/04/2011
29/04/2011
29/04/2011
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) 202-319-2 94-28-0 Sub-chronic toxicity (90-day): oral 26/01/2011 14/03/2011
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) 202-319-2 94-28-0 Reproductive toxicity (two-generation reproductive toxicity) 18/09/2014 03/11/2014
2,2'-iminodi(ethylamine) 203-865-4 111-40-0
Reproductive toxicity (extended one-generation reproductive toxicity study
Reproductive toxicity (pre-natal developmental toxicity)
01/09/2017
01/09/2017
16/10/2017
16/10/2017
2,2'-p-phenylenedioxydiethanol 203-197-3 104-38-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
2,2,2`,2`-Tetrakis(hydroxymethyl)-3,3`-oxydipropan-1-ol 204-794-1 126-58-9 Reproductive toxicity (pre-natal developmental toxicity) 15/03/2011 29/04/2011
2,2,4(or 2,4,4)-Trimethylhexane-1,6-diisocyanate 915-277-1 32052-51-0
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
02/06/2014
02/06/2014
17/07/2014
17/07/2014
2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) 02/11/2018 17/12/2018
2,2,4-trimethylpentane-1,3-diol 205-619-1 144-19-4 Reproductive toxicity (pre-natal developmental toxicity) 18/02/2014 04/04/2014
2,2,6,6-tetramethyl-4-oxopiperidinooxy 220-778-7 2896-70-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl (CAS No 2226-96-2)
14/08/2014
14/08/2014
28/09/2014
28/09/2014
2,2-Bis(hydroxymethyl)-1,3-propanediol (pentaerythritol) 204-104-9 115-77-5 Reproductive toxicity (pre-natal developmental toxicity) 15/03/2011 29/04/2011
2,2-bis(hydroxymethyl)propionic acid // 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid 225-306-3 -
Reproductive toxicity (pre-natal developmental toxicity study)
Sub-chronic oral toxicity (90-day): oral
05/04/2011
05/04/2011
20/05/2011
20/05/2011
2,2-dimethyl-1,3-dioxolan-4-ylmethanol 202-888-7 100-79-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/04/2015
17/04/2015
04/06/2015
04/06/2015
2,2-dimethyl-3-oxopropyl acetate 811-188-6 16184-79-5 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 01/09/2017 16/10/2017
2,2-dimethyl-3-oxopropyl dodecanoate 468-880-2 102985-93-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
2,2-dimethylpropan-1-ol, tribromo derivative 253-057-0 36483-57-5 Reproductive toxicity (pre-natal developmental toxicity) 17/04/2015 04/06/2015
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate 255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
30/06/2014
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate  255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2016
16/12/2016
16/12/2016
30/01/2017
30/01/2017
30/01/2017
2,2`-(octadec-9-enylimino)bisethanol 246-807-3 25307-17-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2011
15/07/2011
15/07/2011
29/08/2011
29/08/2011
29/08/2011
2,2`-iminodi(ethylamine),N-(2-aminoethyl)ethane-1,2-diamine 203-865-4 111-40-0
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
05/04/2011
05/04/2011
05/04/2011
20/05/2011
20/05/2011
20/05/2011
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5
Reproductive toxicity (developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day)
26/05/2010
26/05/2010
26/05/2010
12/07/2010
12/07/2010
12/07/2010
2,3-epoxypropyl neodecanoate 247-979-2 26761-45-5
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): dermal
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid 500-281-4 98362-33-5
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
2,3-epoxypropyl o-tolyl ether 218-645-3 2210-79-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
2,4,4-trimethylpentene 246-690-9 25167-70-8
Reproductive toxicity (pre-natal developmental toxicity) || Note: There are two testing proposals for this endpoint.
Sub-chronic toxicity (90-day): oral
26/03/2018
26/03/2018
11/05/2018
11/05/2018
2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7 6166-86-5
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9)
Sub-chronic toxicity (90 day): inhalation || Note: testing proposed with 2,4,6,8-Tetramethylcyclotetrasiloxane (EC 219-137-4, CAS 2370-88-9)
04/10/2013
04/10/2013
18/11/2013
18/11/2013
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane 219-863-1 2554-06-5
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
03/03/2014
03/03/2014
03/03/2014
03/03/2014
17/04/2014
17/04/2014
17/04/2014
17/04/2014
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4 2370-88-9
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4 2370-88-9
Sub-chronic toxicity (90-day): oral
-
22/11/2017
22/11/2017
08/01/2018
08/01/2017
2,4,6-triallyloxy-1,3,5-triazine 202-936-7 101-37-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): oral
15/04/2011
15/04/2011
30/05/2011
30/05/2011
2,4,6-trinitrotoluene 204-289-6 118-96-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
04/04/2014
04/04/2014
04/04/2014
19/05/2014
19/05/2014
19/05/2014
2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine 426-040-2 25713-60-4
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2011
16/06/2011
16/06/2011
16/06/2011
01/08/2011
01/08/2011
01/08/2011
01/08/2011
2,4,7,9-tetramethyl-4,7-decanediol 451-160-7 17913-76-7
Long-term toxicity to fish
"|| Note: testing proposed with 2,4,7,9-tetramethyldec-5-yne-4,7-diol (EC 204-809-1, CAS 126-86-3)
Reproductive toxicity (pre-natal developmental toxicity)
17/09/2019
17/09/2019
01/11/2019
01/11/2019
2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt 286-344-4 85209-91-2
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
16/10/2014
16/10/2014
16/10/2014
01/12/2014
01/12/2014
01/12/2014
2,4-di-tert-butylphenol 202-532-0 96-76-4 Sub-chronic toxicity (90-day): oral 16/05/2011 30/06/2011
2,4-dimethyl-6-(1-methyl-pentadecyl)phenol 411-220-5 - Reproductive toxicity (pre-natal developmental toxicity) 25/09/2012 12/11/2012
2,4-Pentanedione, peroxide 253-384-9 37187-22-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/11/2015
30/11/2015
14/01/2016
14/01/2016
2,5-di-tert-pentylhydroquinone 201-222-2 79-74-3 Sub-chronic toxicity (90-day): oral 31/05/2011 15/07/2011
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 23/04/2018 07/06/2018
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (pre-natal developmental toxicity) 29/07/2011 12/09/2011
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (two-generation reproductive toxicity) 02/02/2012 19/03/2012
2,6,10,15,19,23-hexamethyltetracosane 203-825-6 111-01-3 Bioaccumulation aquatic / sediment 14/08/2014 28/09/2014
2,6,10-trimethyldodecane 622-542-2 3891-98-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
2,6-di-tert-butylphenol 204-884-0 128-39-2 Sub-chronic toxicity (90-day): oral 16/05/2011 30/06/2011
2,6-dimethyloct-7-en-2-ol 242-362-4 18479-58-8 Reproductive toxicity (two-generation reproductive toxicity) 14/02/2011 31/03/2011
2-(2-(2-butoxyethoxy)ethoxy)ethanol 205-592-6 143-22-6 Reproductive toxicity (pre-natal developmental toxicity) 10/08/2018 24/09/2018
2-(2-naphthyloxy)ethanol 202-228-8 93-20-9 Genetic toxicity in vivo 16/05/2014 30/06/2014
2-(2-thienyl)ethyl toluene-p-sulphonate 254-911-5 40412-06-4 Genetic toxicity in vivo 06/09/2018 22/10/2018
2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol 274-570-6 70321-86-7 Bioaccumulation aquatic / sediment 15/07/2014 29/08/2014
2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol 221-573-5 3147-75-9 Bioaccumulation aquatic / sediment 15/07/2014 29/08/2014
2-(2H-benzotriazol-2-yl)-p-cresol 219-470-5 2440-22-4 Bioaccumulation aquatic / sediment 18/06/2018 02/08/2018
2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene 618-312-6 898566-17-1
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2018
31/01/2018
19/03/2018
19/03/2018
2-(dimethylamino)-2-methylpropan-1-ol 230-279-6 7005-47-2 Reproductive toxicity (pre-natal developmental toxicity) 31/01/2014 17/03/2014
2-[(2-methyl-1-oxoallyl)oxy]ethyl acetoacetate 244-311-1 21282-97-3 Genetic toxicity in vivo 29/04/2014 13/06/2014
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate 254-588-0 39670-09-2
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
30/06/2014
30/06/2014
2-[methyl[(nonafluorobutyl)sulphonyl]amino]ethyl acrylate 266-733-5 67584-55-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
2-amino-2-ethylpropanediol 204-101-2 115-70-8
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-amino-1,3-propanediol
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-amino-1,3-propanediol
18/09/2014
18/09/2014
03/11/2014
03/11/2014
2-aminoethanol, monoester with boric acid 233-829-3 10377-81-8
Long-term or reproductive toxicity to birds
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/07/2011
01/07/2011
01/07/2011
15/08/2011
15/08/2011
15/08/2011



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