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EC number: 907-498-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-02-23 to 2006-03-30 (experimental phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- 1. instead of an effluent/extract/mixture, activated sludge was used as an inoculum, 2. stirring of the content of the bottles was introduced to improve the bioavailability of the test substance
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dioctadecyl 3,3'-thiodipropionate
- EC Number:
- 211-750-5
- EC Name:
- Dioctadecyl 3,3'-thiodipropionate
- Cas Number:
- 693-36-7
- Molecular formula:
- C42H82O4S
- IUPAC Name:
- dioctadecyl 3,3'-sulfanediyldipropanoate
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Secondary activated sludge was obtained from the WWTP Nieuwgraaf in Duiven, The Netherlands (23-02-2006). The WWTP Nieuwgraaf is an activated sludge plant treating predominantly domestic waste water.
- Preparation of inoculum for exposure/pre-treatments/concentrations: A minor deviation of the test procedures described in the guidelines was introduced: instead of an effluent/extract/mixture, activated sludge was used as an inoculum. The activated sludge was preconditioned to reduce the endogenous respiration rates. To this end, 400 mg Dry Weight (DW)/L of activated sludge was aerated for one week. The sludge was diluted to a concentration of 2 mg DW/L in the BOD bottles (van Ginkel and Stroo 1992). - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: The nutrient medium of the Closed Bottle test contained per liter of deionized water: 8.5 mg KH2P04, 21.75 mg K2HP04, 33.3 mg Na2HP04-2H20, 22.5 mg MgS04-7H20, 27.5 mg CaCI2, 0.25 mg FeCI3-6H20. Ammonium chloride was omitted from the medium to
prevent nitrification.
- Solubilising agent (type and concentration if used): Dioctadecyl-3,3'-thiodipropionate is a poorly soluble substance in water and therefore the test substance was first dissolved in dichloromethane (0.08 g/L). The test substance in dichloromethane (7.1 mL) was added to the respective bottles.
- Test temperature: 19-21 °C
- pH: 7 at test start, pH 6 at test end
- Aeration of dilution water: no
- Suspended solids concentration: 2 mg/L d.w.
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: Closed BOD bottles, completely filled. The bottles with the test substance and accompanying control were placed on magnetic stirrers to improve the bioavailability of the test substance. The content of the bottles with acetate and their accompanying controls were not mixed with magnetic stirrers.
- Number of culture flasks/concentration: 10
SAMPLING
- Sampling frequency: Two duplicate bottles of all series were withdrawn for analyses of the dissolved oxygen concentration at day 7, 14, 21, and 28.
- Sampling method: The dissolved oxygen concentrations were determined electrochemically using an oxygen electrode (WTW Trioxmatic EO 200) and meter (WTW OXI 530) (Retsch, Ochten, The Netherlands).
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes 10 bottles
- Abiotic sterile control: no
- Toxicity control: yes, 6 bottles
- Other: solvent control: 6 bottles
STATISTICAL METHODS:
Calculation of the theoretical oxygen demand (ThOD)
The ThODs of dioctadecyl-3,3'-thiodipropionate and of the sodium acetate were calculated from their molecular formulae and molecular weights.
Calculation of the biochemical oxygen demand (BOD)
Provided that the oxygen concentrations in all bottles at the start of the test were equal, the amounts of oxygen consumed in test and reference compound bottles were calculated as follows:
Oxygen consumption (mg/L) = Mc - MtOra
Mc = the mean oxygen level in the control bottles inoculated with activated sludge n days after the start of the test.
MtOra = the mean oxygen concentration in the bottles containing the test compound (t) or the reference compound, sodium acetate (a), and inoculated with activated sludge n-days after the start of the test.
The biological oxygen demand (BOD) mg/mg of the test compound and sodium acetate was calculated by dividing the oxygen consumption by the concentration of the test substance and sodium acetate in the closed bottle, respectively.
Calculation of the biodegradation percentages
The biodegradation was calculated as the ratio of the biochemical oxygen demand (BOD) to the theoretical oxygen demand (ThOD).
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 71
- Sampling time:
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 60
- Sampling time:
- 21 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 47
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 24
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 0 d
BOD5 / COD results
- Results with reference substance:
- The biodegradation percentage of the reference compound, sodium acetate, at day 14 was 81.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- 1) endogenous respiration of 0.8 mg/L at day 28, 2) differences of the replicate values at day 28 were less than 20%, 3) biodegradation reference compound, sodium acetate, at day 14 was 81. 4) oxygen concentrations >0.5 mg/L in all bottles during test
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- -Dioctadecyl-3,3'-thiodipropionate did not cause a reduction in the endogenous respiration. The test substance is therefore considered to be non-inhibitory to the inoculum.
-Dioctadecyl-3,3'-thiodipropionate was biodegraded 71% at day 28 in the Closed Bottle test and therefore the criteria for ready biodegradability' as given in the guideline is fulfilled.
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