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EC number: 902-591-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In compliance with section 1 of Annex XI to Regulation (EC) 1907/2006 (REACH) the study on long-term toxicity to aquatic invertebrates was waived because the chemical safety assessment of the registration substance did not reveal the need to investigate further effects on fish. However, based on a read-across approach to the structural analogue Methanol (CAS 67 -56 -1) a NOEC of >100 mg/L was derived.
Key value for chemical safety assessment
Additional information
According to section 1 of Annex XI to Regulation (EC) 1907/2006 (REACH) testing of long-term toxicity to aquatic invertebrates shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further effects. The registration substance is neither classified for environmental hazards according to Regulation (EC) 1272/2008 (CLP), nor is it identified as PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. This conclusion is supported by assessments for the structural analogues Methanol (CAS 67-56-1) and Methyl acetate (CAS 79-20-9) provided in its public ECHA REACH dossiers demonstrating that long-term toxicity to fish is not to be expected. Therefore, generating additional data is scientifically not justified.
Nevertheless, supporting information available for the structural analogue Methanol is presented below.
Supporting information
Methanol
Results from fully reliable studies on chronic toxicity of methanol to aquatic invertebrates are not available.
In a semi-static young Daphnia magna (< 24 hours old, 10 animals per treatment) were exposed to nominal test item concentrations of 1219, 4385, 8771, 12190 and 19260 mg/L. The temperature and light was maintained at 20 ± 1 °C with a photoperiod of 14 h light/10 h dark throughout the study. The 21-day NOEC (reproduction) and 21-day NOEC (growth) were determined to be 122 g/L and 4380 mg/L, respectively (Dom et al., 2012).
Roex et al. (2000) and Raimondo et al. (2007) investigated the variability in acute-to-chronic ratios (ACRs) based on an extensive data set on acute aquatic toxicity of various chemicals. As a result, Roex et al. (2000) derived an average ACR for nonpolar narcotics of 2.58 +/- 1.57. According to Raimondo et al. (2007) the median ACR for chemicals classified as nonpolar narcotics is 9.9, which is in the same order of magnitude as the ACR determined by Roex et al. (2000).
Conclusion
In compliance with section 1 of Annex XI to Regulation (EC) 1907/2006 (REACH) the study on long-term toxicity to fish was waived because the chemical safety assessment of the registration substance did not reveal the need to investigate further effects on fish. However, supporting information on long-term toxicity of the source substance methanol were taken into account. The results of a 21 d study on the toxicity of methanol on Daphnia magna are reported in a publication of Dom et al. (2012). The study reports a NOEC of 122 mg/L for reproduction of Daphnis magna. Additionally, several short-term toxicity studies are available for aquatic invertebrates, all consistently demonstrating a very low acute toxicity of methanol. Since methanol exerts toxicity with a non-specific mode of action (narcotic toxicity), the chronic toxicity to Daphnia magna can be reasonably extrapolated from acute data using an acute to-chronic ratio of 10 (Raimondo et al., 2007; Roex at al., 2000). A chronic toxicity of >100 mg/L is thus to be expected for the source substance Methanol. By applying a read across approach NOEC of the target substance for long-term toxicity to aquatic invertebrates is considered to be >100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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