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EC number: 619-409-6 | CAS number: 99208-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The aim of this study is to assess the hazardous potential of the substance10-(2, 5-Dihydroxyphenyl)-10H-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO-HQ)with respect to repeated dose toxicity and related reproductive and developmental toxicity effects. The assessment will include expert analysis on the reactivity and possible transformations of the target chemicalas well asin silicopredictions.
Conclusions
Based on RA prediction to the target chemical using experimental data for its two moieties:
- NOEL = 105 mg/kg bw/d
- LOEL = 149 mg/kg bw/d
It is assumed that DOPO-HQ could elicit low specific target organ (i.e. kidney and/or liver) toxicity effect due to the HQ fragment.
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: oral, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. Literature search and expert analysis of the transformations and toxicological effects of DOPO-HQ and its both moieties (DOPO and HQ) have been performed
2. Given the lack of toxicity of the DOPO, it is assumed that the reactivity of DOPO-HQ is due to the HQ fragment which could be transformed to the toxic para-benzoquinone as a result of in vivo metabolism. Based on theoretical expert considerations, it is expected that the toxic effect could be additionally reduced.
a. It is expertly assumed that the formation of quasi-aromatic six-membered hydrogen bond with one of the hydroxyl groups of the HQ fragment will
prevent the extensive oxidation of DOPO-hydroquinone fragment to a toxic para-benzoquinone metabolite.
b. Furthermore, the presence of hydroxyl groups in DOPO-HQ could lead to the excretion of a large part of the target compound via the urine as
glucuronide and sulfate conjugates. This was confirmed by the in vivo rat metabolic simulator available in TIMES.
3. In silico predictions for repeated dose, reproductive and developmental toxicity have been done by Toolbox using the read-across approach. The results confirmed the theoretical analysis based on expert input. Predictions by TIMES QSAR models have been also used for collecting weight of evidences. - Qualifier:
- no guideline followed
- Guideline:
- other: QSAR
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 105 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other:
- Remarks:
- QSAR
- Key result
- Critical effects observed:
- no
- Lowest effective dose / conc.:
- 0 other: QSAR
- Organ:
- kidney
- liver
- Conclusions:
- Conclusions on RDT:
Based on RA prediction to the target chemical using experimental data for its two moieties:
- NOEL = 105 mg/kg bw/d
- LOEL = 149 mg/kg bw/d
It is assumed that DOPO-HQ could elicit low specific target organ (i.e. kidney and/or liver) toxicity effect due to the HQ fragment. - Executive summary:
Repeated dose toxicity (RDT) is a hazard property associated with toxicological effects occurring as a result of repeated daily dosing with/ or exposure to a substance for a specified period up to the expected lifespan of the test species.
Table 2. Experimental RDT NOEL/NOAL data for DOPO and HQ
DOPO
HQ
Exp. data
Test guideline
Duration
Data source
Exp. data
Test guideline
Duration
Data source
NOEL
100 mg/kg
TG 422
42 d
Repeated Dose Toxicity HESS database
25 mg/kg
TG NTP
91 d
Repeated Dose Toxicity HESS database
LOEL
100 mg/kg
TG 422
42 d
Repeated Dose Toxicity HESS database
50 mg/kg
TG 424
91 d
ECHA CHEM database
NOEL (RDT, oral, rat, whole body, total)of the target is predicted to be105 mg/kg (Figure 6, see full report).
LOEL (RDT, oral, rat, whole body, total)of the target is predicted to be149 mg/kg(Figure 7, see full report).
Additional data for DOPO, tested in arepeated dose 90-day oral toxicity in rats,is available in the ECHA CHEM database.Based on the results in the study it was concluded that there is no evidence of specific target organ toxicity and it was defined a no adverse effect level (NOAEL) dose = 1064 mg/kg bw/day.
Reference
Please see full report
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Dose descriptor:
- NOAEL
- 105 mg/kg bw/day
- Organ:
- kidney
- liver
Additional information
Justification for classification or non-classification
Findings and NOEL/LOEL do do not justify classification under GHS/CLP
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