[No public or meaningful name is available]

Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Remove to fresh air. If any trouble breathing, get immediate

medical attention. Administer artificial

respiration if breathing has ceased. If irritation or

symptoms occur or persist, consult a physician.

Emergency measure - Eyes: In case of eye contact, immediately rinse eyes thoroughly

with plenty of water. If wearing contact lenses, remove only

after initial rinse, and continue rinsing eyes for at least

15 minutes. If irritation occurs or persists, consult a

physician.

Emergency measure - Skin: In case of skin contact, while wearing protective gloves,

carefully remove any contaminated clothing, including shoes,

and wash skin thoroughly with soap and water. If irritation

or symptoms occur or persist, consult a physician.

Emergency measure - Ingestion: Rinse mouth and drink a glass of water. Do not induce

vomiting unless under the direction of a qualified

medical professional or Poison Control Center. If symptoms

persist, consult a physician.

Fire-fighting measures

Recommended extinguishing agent: Water, carbon dioxide, and chemical powder.

Product arising from burning: Possible evolution of carbon oxides, nitrous oxides and

hydrogen bromide.

Product determined by test: N

Protective equipment: Full protective equipment must be worn including self-

contained breathing apparatus.

Accidental release measures

Emergency measures in case of spillage: Evacuate personnel from immediate vicinity.

Wear appropriate personal protective equipment conforming to

the relevant national or international standards.

Contain spillages with a suitable inert material (e.g. sand

or soil). Carefully transfer the spillage to waste

containers. Containers must be labelled in the same way as

original containers.

Clean the spillage area with water and detergent.

Dispose of waste material by incineration in accordance with

local regulations.

Handling and storage

Handling: Sampling and splitting the material in the Warehouse is

performed within laminar airflow booths with appropriate

Personal Protective Equipment (PPE).

On the plant, Powder Transfer System (PTS, vacuum operated),

supplemented by local exhaust ventilation (LEV) and PPE are

used for all manual handling operations.

Finally, reaction mixture solution sampling via Top Reactor

Sampler (Rapid Transfer Port). Contained sampling unit,

minimal exposure to reaction mixture.

Keep containers adequately sealed during material transport,

or when material is not in use.

Wear appropriate personal protective equipment.

Storage: Keep in a cool, dry, well-ventilated area.

Packaging of the substance and or preparation: Polyethylene lined bag within aluminium foil bag (Heat

sealed) within fibre-board drums.

Typical weight of 25 kg per drum.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Transport: Not applicable.

SpecialProvisions

Stability and reactivity

Danger other than fire: Avoid humidity, strong acids and oxidisers.  Possible

reaction products, carbon oxides, nitrogen oxides and

hydrogen bromide.

Chemical reaction with water: Unknown.

Dust explosion: The substance is an organic powder presenting the

possibility of a dust explosion.

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: The substance is used as an intermediate in the synthesis of

an active pharmaceutical ingredient.  Therefore it is

expected that it will be consumed in the processes where it

is employed.  Hence the need for recovery / recycling of the

substance does not apply in this case.

Industry - Possibility of neutralisation: None known.

Industry - Possibility of destruction: controlled discharge: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Industry - Possibility of destruction - incineration: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Industry - Possibility of destruction - water purification: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Industry - Possibility of destruction - other: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Public at large - Possibility of recovery/recycling: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Public at large - Possibility of neutralisation: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Public at large - Possibility of destruction: controlled discharge: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Public at large - Possibility of destruction - incineration: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Public at large - Possibility of destruction - water purification: The substance is a pharmaceutical intermediate and is

completely consumed during processing.

Public at large - Possibility of destruction - others: The substance is a pharmaceutical intermediate and is

completely consumed during processing.