Registration Dossier
Registration Dossier
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EC number: 444-900-5 | CAS number: 49667-22-3
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
The following ecotoxicological data are available
Daphnia magna (invertebrate) (Tobor-Kaplon, 2016a)
· 48h-EC50 of 60 mg/L (95%CL: 54-79 mg/L)
Pseudokirchneriella subcapitata (green alga) (Tobor-Kaplon, 2016b)
· 72h-ErC50: >100 mg/L
· 72h-NOECr: 32 mg/L
Effects levels based on biomass are a 72h-EbC50 of 449 mg/L and a 72h-NOECb of 10 mg/L.
The ECHA Guidance on the application of CLP criteria states that for algae, “Classification shall be based on both the algal growth rate reduction endpoints (ErC50 and NOErC) provided that the control growth is exponential. This endpoint is preferred because it is not dependent on the test design, whereas the endpoint, biomass (growth) inhibition (EbC50) depends on both, growth rate of the test species as well as test duration and other elements of test design”.
Acute classification under CLP: based on the lowest EC50.
Daphnia magna is the most sensitive species (ERVacute: 60 mg/L). Based on this value, the substance is not classified for the Aq.Acute enpoint.
Chronic classification under CLP:
Chronic data are missing for some trophic levels; (no data for fish and forD.magna(most sensitive taxonomic group). According to the 2nd ATP of the CLP (2011), chronic classification needs to be determined in two ways, and the most stringent classification has to be used
a) based on chronic data
b) surrogate method (based on acute data).
Using the only available chronic value of 32 mg/L, the substance is not classified for the Aq.Acute enpoint.
Using the surrogate method, the ERVacute of 60 mg/L results in an Aq. Chronic Cat.3 classification.
Conclusion:
The substance is not classified for the acute environmental endpoint
The substance is classified as Aq.Chronic Cat.3
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