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EC number: 307-988-5 | CAS number: 97808-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two biodegradation studies as-
1. and 2. - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine
- Molecular formula: C11H23N7O3S
- Molecular weight: 333.41 g/mol
- Smiles notation: C=O_CC1CCC(S(N)(=O)=O)CC1_Nc1nc(N)nc(N)n1
- Substance type: Organic
- Physical state: Solid - Oxygen conditions:
- not specified
- Inoculum or test system:
- other: 1. Mixed inoculum 2. activated sludge (adaptation not specified)
- Details on inoculum:
- 1. Mixed Inoculum Preparation:Polyseed were used for this study. 1 polyseed capsule were added in 500 ml D.I water and then stirred for 1 hour for proper mixing and functioning of inoculum. This gave the bacterial count as 107 to 108 CFU/ml. At the regular interval microbial plating was also performed on agar to confirm the vitality and CFU count of microorganism.
2. - Concentration of sludge: 30 mg/l - Duration of test (contact time):
- 28 d
- Initial conc.:
- 0.7 other: ml/125 ml
- Based on:
- test mat.
- Remarks:
- (1)
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Remarks:
- (2)
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- TOC removal
- Parameter followed for biodegradation estimation:
- other: BOD and UV-Vis
- Details on study design:
- 1. TEST CONDITIONS
- Composition of medium: OECD mineral medium was used for the study
- Test temperature: 20°C
- Continuous darkness: Yes
- Other: The water used in this study is deionized water.
TEST SYSTEM
- Culturing apparatus: The apparatus used in this study is BOD bottles; with glass stoppers (125 ml), BOD incubator & oxygen electrode and meter.
CONTROL AND BLANK SYSTEM
- Inoculum blank: it contains only test inoculum
- Procedure control: contains reference compound and inoculum
2. Standard type - Reference substance:
- other: 1. Sodium Benzoate 2. No data
- Parameter:
- % degradation (O2 consumption)
- Value:
- 65.24
- Sampling time:
- 28 d
- Remarks on result:
- other: Other details not known
- Parameter:
- other: BOD
- Value:
- 93
- Sampling time:
- 21 d
- Remarks on result:
- other: Other details not known
- Parameter:
- % degradation (TOC removal)
- Value:
- 95.3
- Sampling time:
- 21 d
- Remarks on result:
- other: Other details not known
- Parameter:
- other: UV-Vis
- Value:
- 100
- Sampling time:
- 21 d
- Remarks on result:
- other: Other details not known
- Details on results:
- 1. The oxygen consumed by the test systems was corrected for oxygen consumption occurring in the blank test systems.The BOD Values (mgO2/mg) and percent biodegradation results for each test system are reported in Tables 2 and 3, respectively. The BOD28 value of test chemical was observed to be 1.07 mgO2/mg. ThOD was determined by calculation as 1.64 mgO2/mg. % degradation was calculated using the values of BOD and ThOD for test item and was determined to be 65.24% at 20 ± 1°C. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was found to be 78.31%. Degradation of Sodium Benzoate exceeds 45.18% on 7 days & 59.03% on 14th day. The activity of the inoculum is thus verified and the test can be considered as valid.
2. Test substance undergoes 93, 95.3 and 100% degradation by BOD, TOC removal and UV-Vis parameter in 21 days. - Results with reference substance:
- 1. Degradation of Sodium Benzoate exceeds 45.18% on 7 days & 59.03% on 14th day. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was found to be 78.31%.
2. No data - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the percentage degradation of the test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine can be expected to be ranges from 65.24 to 100%, respectively in 28 days. Thus, based on this, test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine is considered to be readily biodegradable in nature.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the biodegradability of the test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine. The studies are as mentioned below:
28-days Closed Bottle test following the OECD guideline 301 D to determine the ready biodegradability of the test item. The test system included control, test item and reference item. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % degradation was calculated using the values of BOD and ThOD for test item and reference item. The BOD28 value of test chemical was observed to be 1.07 mgO2/mg. ThOD was calculated as 1.64 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to Closed Bottle test was determined to be 65.24%. Based on the results, the test item, under the test conditions, was readily biodegradable in nature.
Another biodegradation study was conducted for 21 days for evaluating the percentage biodegradability of test substance. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 93, 95.3 and 100% degradation by BOD, TOC removal and UV-Vis parameter in 21 days. Thus, based on percentage degradation,test chemicalis considered to be readily biodegradable in nature.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the percentage degradation of the test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine can be expected to be ranges from 65.24 to 100%, respectively in 28 days. Thus, based on this, test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine is considered to be readily biodegradable in nature.
Reference
1.
TABLE: D.O Values(mg/L)
No. of Days |
Inoculum Blank (control) |
Test Suspension |
Procedure Control (Reference Item) |
0 |
7.1 |
6.9 |
7.1 |
7 |
6.7 |
4.5 |
3.7 |
14 |
6.5 |
3.1 |
2.6 |
21 |
6.2 |
2.0 |
1.1 |
28 |
5.9 |
1.4 |
0.7 |
Table: BOD values (mgO2/mg)
No. of Days |
Test Suspension |
Procedure Control (Reference Item) |
0 |
0 |
0 |
7 |
0.5 |
0.75 |
14 |
0.8 |
0.98 |
21 |
1.0 |
1.27 |
28 |
1.07 |
1.3 |
Table: PERCENT BIODEGRDATION RESULTS
No. of Days |
Test Suspension |
Procedure Control (Reference Item) |
0 |
0% |
0% |
7 |
30.48% |
45.18% |
14 |
48.78% |
59.03% |
21 |
60.97% |
76.5% |
28 |
65.24% |
78.31% |
Table: BOD28, THOD AND % BIODEGRADATION VALUES
Method details |
BOD28 (mgO2/mg) |
ThOD (mgO2/mg) |
% Biodegradation |
Test Item |
1.07 |
1.64 |
65.24 |
Reference Item |
1.3 |
1.66 |
78.31 |
TABLE: pH OF CLOSED BOTTLE TEST
No. of Days |
Inoculum Blank (control) |
Test Suspension |
Procedure Control (Reference Item) |
0 |
7.3 |
6.6 |
7.3 |
7 |
6.5 |
7 |
6.5 |
14 |
6.9 |
6.8 |
6.8 |
21 |
6.9 |
7 |
6.8 |
28 |
6.7 |
6.7 |
6.6 |
2. No data
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the percentage degradation of the test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine can be expected to be ranges from 65.24 to 100%, respectively in 28 days. Thus, based on this, test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine is considered to be readily biodegradable in nature.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the biodegradability of the test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine. The studies are as mentioned below:
28-days Closed Bottle test following the OECD guideline 301 D to determine the ready biodegradability of the test item. The test system included control, test item and reference item. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % degradation was calculated using the values of BOD and ThOD for test item and reference item. The BOD28 value of test chemical was observed to be 1.07 mgO2/mg. ThOD was calculated as 1.64 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to Closed Bottle test was determined to be 65.24%. Based on the results, the test item, under the test conditions, was readily biodegradable in nature.
Another biodegradation study was conducted for 21 days for evaluating the percentage biodegradability of test substance. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 93, 95.3 and 100% degradation by BOD, TOC removal and UV-Vis parameter in 21 days. Thus, based on percentage degradation,test chemicalis considered to be readily biodegradable in nature.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the percentage degradation of the test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine can be expected to be ranges from 65.24 to 100%, respectively in 28 days. Thus, based on this, test chemical Benzenesulfonamide, 4-methyl-, reaction products with formaldehyde and melamine is considered to be readily biodegradable in nature.
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