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EC number: 270-219-6 | CAS number: 68413-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 March 2004 - 24 June 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Hydrolysis of component 2 in the sample solution occured during the course of the water solubility test.
- Principles of method if other than guideline:
- It is evident from the information obtained in the hydrolysis study and data relating to the pH or the test material in water, that hydrolysis of component 2 in the sample solution occurred during the course of the water solubility test. The analytical results support however, that sufficient excess undissolved material was present in each sample to ensure saturation over the full time scale of the test.
Sample 1C and Sample 2D have been excluded from further calculation of the water solubility of component 2. This was due to inconsistency with all remaining data points and also to represent a worst case scenario for environment considerations.
Although chemical composition for the test material was supplied, the absence of accurate relative percentage compositions prevented the calculation of definitive water solubilities for each individual component. Although the two components were monitored individually, the results calculated are with respect to the test material as a whole. For example, the concentration of component 1 found in solutions was as if 2.86 x 10^-2 g/l had dissolved. Due to this, the values have been reported as equivalent test material concentration.
Since the water solubility was greater than 1 x 10^-3 for both components, the partition coefficient, rather than the fat solubility was determined, as required by the Protocol. - GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Purity: Not specified
- Description: light amber coloured, slightly viscous liquid
- Storage: room temperature, in the dark - Water solubility:
- 0.029 g/L
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 5.2
- Remarks on result:
- other: Component 1. Dibutyl fumarate
- Water solubility:
- 0 g/L
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 5.2
- Remarks on result:
- other: Component 2. Registered substance
- Details on results:
- -Preliminary test:
The preliminary estimate of water solubility was 2.36 E-2 g/l and 5.52 E-4 g/l for component 1 and component 2, respectively. - Conclusions:
- The water solubility of the test material is 2.33 E-4 g/l at 20.0 +/- 0.5°C (SafePharm, 2004).
Reference
Description of key information
The water solubility of the test material is 2.33 E-4 g/l at 20.0 +/- 0.5°C (SafePharm, 2004).
Key value for chemical safety assessment
- Water solubility:
- 0.029 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.