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EC number: 259-701-7 | CAS number: 55542-27-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 Nov 2000 - 28 Dec 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 17β-hydroxy-17-(3-hydroxypropyl)androst-4-ene-4-one
- EC Number:
- 259-701-7
- EC Name:
- 17β-hydroxy-17-(3-hydroxypropyl)androst-4-ene-4-one
- Cas Number:
- 55542-27-3
- Molecular formula:
- C22H34O3
- IUPAC Name:
- 17 beta-Hydroxy-17 alpha-(3-hydroxypropyl)-4-androsten-3-one
- Details on test material:
- - Name of test material (as cited in study report): Hydroxypropyltesto
- Analytical purity: 91.2%
- Lot/batch No.: 59012052
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 3.3 mg/L
- Based on:
- test mat.
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- > 10
- Sampling time:
- 28 d
Any other information on results incl. tables
Table 2: Degradation ofthe test item and reference substance | |||
Day | Degradation % | ||
Procedure control | Test item | ||
1 | 51 | 0 | |
4 | 76 | 1 | |
7 | 79 | 3 | |
11 | 86 | 0 | |
14 | 85 | 13* | |
18 | - | 1 | |
21 | - | 2 | |
26 | - | 5 | |
28 | - | 5 | |
*mean value of 21 % and 5 % degradation |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- In the present study Iess oxygen uptake by the test item was measured. The calculated results
do not exceed 10 % degradation. For this reason in the test for ready biodegradability the test
item seems to be not readily biodegradable. - Executive summary:
The ready biodegradation of Hydroxypropyltesto in an aerobic aqueous medium was tested by the Closed Bottle Test according to OECD guideline No. 301 D. Mineral medium containing a known concentration of the test item was inoculated with microorganisms from the eflluent of a treatment plant (domestic sewage) and incubated in the dark over a 28 day period. Degradation was followed by oxygen evolution twice a week. The amount of oxygen taken up by the microbial population during biodegradation of the test item was expressed as a percentage of the theoretical oxygen demand of the test item. Throughout the test no degradation of the test item was measured. The result is not due to inhibition of the inoculum. The result of a toxicity control showed that the concentration of test item tested has no inhibitory effect to the inoculum. The pass level for ready bio degradation (60 per cent degradation) was not reached. Thus in the test for ready biodegradability the test item seems to be not readily biodegradable.
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