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EC number: 249-854-8 | CAS number: 29797-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a skin irritation study according OECD Guideline 404, the test
substance was found to be irritating (Ruf/Bayer AG, 1987).
Additionally this finding was supported by a skin irritation/corrosion
study where the test substance was found to be irritating to the skin
(Schreiber/Bayer AG, 1981).
In an eye irritation study according to OECD guideline 405 slight
effects were observed, but according to classification and labeling the
substance is not irritating to the eye (Ruf/Bayer AG, 1987).
In another eye irritation study the test substance was found to be
non-irritating to the eye (Schreiber/Bayer AG, 1981).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: same animals served as control (one flanc: test substance, other flanc : water
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 d
- Number of animals:
- 3
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1h, 24h, 48h, 72h, 7d, 14d
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h, 24 h, 48 h, 72 h, 7 d, 14 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 1h, 24h, 48h, 72h, 7d, 14d
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 1h, 24h, 48h, 72h, 7d, 14d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 1h, 24h, 48h, 72h, 7d, 14d
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 1h, 24h, 48h, 72h, 7d, 14d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.22
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Other effects:
- In all animals from day 7 up to day 14 formation of scales was observed.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Skin Irrit. 2 (not fully reversible within 14 days - formation of scales).
- Executive summary:
In a skin irritation study according OECD Guideline 404, 3 female New Zealand White rabbits were treated with 500 µl of test substance to the abraded skin of one flank. The other flank served as control and was treated only with water. The test area was covered with a semiocclusive plaster. After 4 h the plasters were removed and the test areas were washed with water. Erythema and edema formation were evaluated after 24h, 48h, 72h, 7d and 14d. In all animals from day 7 up to day 14 formation of scales was observed. The test substance was found to be irritating.
Reference
Results:
Animal No/ bw/ sex | DRAIZE-grade after | |||||||||||||
1h | 24h | 48h | 72h | 7d | 14d | Irritation scores | ||||||||
Er | Ed | Er | Ed | Er | Ed | Er | Ed | Er | Ed | Er | Ed | Er | Ed | |
F59 (3.4 kg) female | 1 | 1 | 2 | 1 | 3 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 2.3 | 1 |
G53 (3.0 kg) female | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 0 | 0 | 2.0 | 1 |
E51 (3.8 kg) female | 1 | 1 | 2 | 1 | 3 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 2.3 | 1 |
Er = Erythema
Ed = Edema
In all animals from day 7 up to day 14 formation of scales was observed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the test substance was applied to one eye, the other eye was not treated and served as control
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no symptom seen
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no symptom seen
- Irritation parameter:
- other: Conjunctiva reddening
- Basis:
- animal #1
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7d
- Remarks on result:
- other: Conjunctiva reddening
- Irritation parameter:
- other: Conjunctiva swelling
- Basis:
- animal #1
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other: Conjunctiva swelling
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no symptom seen
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no symptom seen
- Irritation parameter:
- other: Conjunctiva reddening
- Basis:
- animal #2
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72h
- Remarks on result:
- other: Conjunctiva reddening
- Irritation parameter:
- other: Conjunctiva swelling
- Basis:
- animal #2
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Remarks on result:
- other: Conjunctiva swelling
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no symptoms seen
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no symptoms seen
- Irritation parameter:
- other: Conjunctiva reddening
- Basis:
- animal #3
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7d
- Remarks on result:
- other: Conjunctiva reddening
- Irritation parameter:
- other: Conjunctiva swelling
- Basis:
- animal #3
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
- Remarks on result:
- other: Conjunctiva swelling
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable - score = = at any time point
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable - score = 0 at any time point
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.9
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 2 days
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Slight effects were observed, but according to classification and labeling the substance is not irritating to the eye.
- Executive summary:
In an eye irritation study according to OECD guideline 405 the test substance (100 µl) was applied to one eye of 3 New Zealand White rabbits. The other eye was left untreated and served as control. After 24h the treated eyes were rinsed with physiological saline solution. Examinations took place after 1h, 24h, 48h, 72h and 7d and were evaluated according to DRAIZE.
Slight effects were observed, but according to classification and labeling the substance is not irritating to the eye.
Reference
Results:
DRAIZE-Grade | ||||||||||
Animal No./ bw/ sex | examined organ | symptom | 1h | 24h | 48h | 72h | 7d | 14d | 21d | Irritation score |
E11 (3.6 kg) female | Cornea | -cloudiness | 0 | 0 | 0 | 0 | 0 | - | - | 0.0 |
-area | 0 | 0 | 0 | 0 | 0 | - | - | / | ||
Iris | 0 | 0 | 0 | 0 | 0 | - | - | 0.0 | ||
Conjunctivae | reddening | 1 | 1 | 1 | 1 | 0 | - | - | 1.0 | |
swelling | 2 | 1 | 0 | 0 | 0 | - | - | 0.3 | ||
lacrimation | 2 | 1 | 0 | 0 | 0 | - | - | / | ||
C40 (3.2 kg) female | Cornea | -cloudiness | 0 | 0 | 0 | 0 | 0 | - | - | 0.0 |
-area | 0 | 0 | 0 | 0 | 0 | - | - | / | ||
Iris | 0 | 0 | 0 | 0 | 0 | - | - | 0.0 | ||
Conjunctivae | reddening | 1 | 1 | 1 | 0 | 0 | - | - | 0.7 | |
swelling | 1 | 1 | 1 | 0 | 0 | - | - | 0.7 | ||
lacrimation | 1 | 1 | 0 | 0 | 0 | - | - | / | ||
O41 (3.5 kg) female | Cornea | -cloudiness | 0 | 0 | 0 | 0 | 0 | - | - | 0.0 |
-area | 0 | 0 | 0 | 0 | 0 | - | - | / | ||
Iris | 0 | 0 | 0 | 0 | 0 | - | - | 0.0 | ||
Conjunctivae | reddening | 1 | 1 | 1 | 1 | 0 | - | - | 1.0 | |
swelling | 1 | 0 | 0 | 0 | 0 | - | - | 0.0 | ||
lacrimation | 1 | 1 | 0 | 0 | 0 | - | - | / |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In a skin irritation study according OECD Guideline 404, 3 female New Zealand White rabbits were treated with 500 µl of test substance to the abraded skin of one flank. The other flank served as control and was treated only with water. The test area was covered with a semiocclusive plaster. After 4 h the plasters were removed and the test areas were washed with water. Erythema and edema formation were evaluated after 24h, 48h, 72h, 7d and 14d. In all animals from day 7 up to day 14 formation of scales was observed. The test substance was found to be irritating (Ruf/ Bayer AG, 1987)..
Additionally this finding was supported by a skin irritation/corrosion study in New Zealand White rabbits where the test substance ( 500 µl) was administered to the intact and to the scarified flank skin of 6 rabbits. The test region was covered with an occlusive PVC foil. The duration of treatment was 24 h and the observation period 8 d. The erythema and edema grade was evaluated after 24, 48, 72 and 8 d. The 48 h values are not defined in the test results. The 8 d results were given, but were not taken into consideration for the primary irritation score. The score was 3.3 and after 8 d still a slight irritation with scales could be observed in the rabbits. The test substance was found to be irritating to the skin (Schreiber/Bayer AG, 1981).
In an eye irritation study according to OECD guideline 405 the test substance (100 µl) was applied to one eye of 3 New Zealand White rabbits. The other eye was left untreated and served as control. After 24h the treated eyes were rinsed with physiological saline solution. Examinations took place after 1h, 24h, 48h, 72h and 7d and were evaluated according to DRAIZE.
Slight effects were observed, but according to classification and labelling the substance is not irritating to the eye (Ruf/ Bayer AG, 1987).
This finding was supported by another eye irritation study where the test substance (100 µl) was applied to one eye of 6 male New Zealand White rabbits (average bw = 2.3 kg). The other eye was left untreated and served as control. Examinations took place with the aid of an ophthalmoscope after 24h, 48h and 72h and 8d after test start. The 8 d value was not taken into consideration for the evaluation of the irritation index which was 0.1. The test substance was found to be non-irritating to the eye (Schreiber/Bayer AG, 1981).
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Skin Irrit. 2 ( H315: Causes skin irritation) is justified. No classification for eye irritation is required.
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