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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 236-537-4 | CAS number: 13423-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 142 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 15
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 2 125 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No route to route extrapolation required: Inhalation - Inhalation. The starting point of 3171 mg/m3 was adjusted to light work by multiplying by 0.67 according to ECHA guidance.
- AF for dose response relationship:
- 3
- Justification:
- Default value from ECHA guidance for LOAEC to NOAEC extrapolation.
- AF for differences in duration of exposure:
- 1
- Justification:
- Acute effect - no time extrapolation is appropriate.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- According to ECHA guidance, no allometric scaling necessary for inhalation.
- AF for other interspecies differences:
- 1
- Justification:
- According to ECHA guidance, no interspecies extrapolation necessary for inhalation.
- AF for intraspecies differences:
- 5
- Justification:
- Default value from ECHA guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The results of a chronic study on the read-across substance, tetrahydrofuran, provides robust evidence of a lack of significant systemic toxicity.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 142 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 15
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 2 125 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No route to route extrapolation required: Inhalation - Inhalation. The starting point of 3171 mg/m3 was adjusted to light work by multiplying by 0.67 according to ECHA guidance.
- AF for dose response relationship:
- 3
- Justification:
- Default value from ECHA guidance for LOAEC to NOAEC extrapolation.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- According to ECHA guidance, no allometric scaling necessary for inhalation.
- AF for other interspecies differences:
- 1
- Justification:
- According to ECHA guidance, no interspecies extrapolation necessary for inhalation.
- AF for intraspecies differences:
- 5
- Justification:
- Default value from ECHA guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The results of a chronic study on the read-across substance, tetrahydrofuran, provides robust evidence of a lack of significant systemic toxicity.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 142 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 15
- Dose descriptor:
- LOAEC
- AF for dose response relationship:
- 3
- Justification:
- Default value from ECHA guidance for LOAEC to NOAEC extrapolation.
- AF for differences in duration of exposure:
- 1
- Justification:
- Acute effect - no time extrapolation is appropriate.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- According to ECHA guidance, no allometric scaling necessary for inhalation.
- AF for other interspecies differences:
- 1
- Justification:
- According to ECHA guidance, no interspecies extrapolation necessary for inhalation.
- AF for intraspecies differences:
- 5
- Justification:
- Default value from ECHA guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The results of a chronic study on the read-across substance, tetrahydrofuran, provides robust evidence of a lack of significant systemic toxicity.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 142 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 15
- Dose descriptor starting point:
- LOAEC
- AF for dose response relationship:
- 3
- Justification:
- Default value from ECHA guidance for LOAEC to NOAEC extrapolation.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- According to ECHA guidance, no allometric scaling necessary for inhalation.
- AF for other interspecies differences:
- 1
- Justification:
- According to ECHA guidance, no interspecies extrapolation necessary for inhalation.
- AF for intraspecies differences:
- 5
- Justification:
- Default value from ECHA guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The results of a chronic study on the read-across substance, tetrahydrofuran, provides robust evidence of a lack of significant systemic toxicity.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 18 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No route-to-route extrapolation made. Assume 100% of dermal exposure is absorbed through the skin.
- AF for dose response relationship:
- 1
- Justification:
- No adjustment needed. NOAEL used as the starting point.
- AF for differences in duration of exposure:
- 1
- Justification:
- Study is a 2-generation reproduction study. NOAEL applies to F0 and F1 generations, spanning exposures well beyond 90 days; default AF assigned.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default allometric scaling for rat from ECHA guidance.
- AF for other interspecies differences:
- 1
- Justification:
- According to ECHA guidance, no interspecies extrapolation necessary.
- AF for intraspecies differences:
- 5
- Justification:
- Worker default AF from ECHA guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The results of a chronic study on the read-across substance, tetrahydrofuran, provides robust evidence of a lack of significant systemic toxicity.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
Tetrahydro-3-methylfuran (3-methyl-THF) is imported into the EU as a monomer in a finished polymer and, therefore, does not present a hazard to workers in this form. Nonetheless, worker DNELs have been derived in the event that it becomes necessary to import the monomer itself. Although data on 3-methyl-THF are limited, appropriate DNELs can nonetheless be derived with support from the read-across substance, tetrahydrofuran. For inhalation exposures, data from 3-methyl-THF itself were used to derive the short-term DNELs covering local and systemic effects. And, given that the short-term DNEL was lower than the long-term systemic DNEL derived from the read-across substance, it was concluded that the short-term DNEL would be adequately protective on long-term systemic effects and should be used as the long-term DNEL. For long-term dermal exposures (systemic effects), data from the read-across substance were used. For long-term and acute local skin and eye effects, it was concluded that no threshold could be determined and no DNELs could be derived given that the substance is severely irritating or corrosive to skin and causes irreversible effects on the eye.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Tetrahydro-3-methylfuran (3-methyl-THF) is imported into the EU as a monomer in a finished polymer and, therefore, presents no hazard to the general population.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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