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EC number: 233-143-4 | CAS number: 10043-84-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data available for the similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical manganese(2+) bis(phosphinate) (10043-84-2).The studies are as mentioned below:
Study 1
In acute oral toxicity study, male Swiss strain Albino mice were treated with test material in dose concentration 2330mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice. Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.
Study 2
In acute oral toxicity study, male and female Wistar rats were treated with test material in dose concentration 2150mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated rats at 2150mg/kg bw. Behavioural changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated rats .Therefore, LD50 was considered to be 2150mg/kg bw. When rats were treated with test material orally.
Study 3
In acute oral toxicity study, female Wistar rats were treated with test material in dose concentration 2000mg/kg bw orally according to OECD Test Guideline (TG) 420.No mortality was observed in treated rats at 2000 mg/kg bw. Therefore, LD50 was considered to be >2000 mg/kg bw. When rats were treated with test material orally
Thus, based on the above summarised studies, manganese(2+) bis(phosphinate) (10043-84-2) and it’s read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, manganese(2+) bis(phosphinate) (10043-84-2)cannot be classified for acute oral toxicity. Hence, based on the data available for the similar read across, test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic at least in the dose range of 2000-2330 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is based on three acute oral toxicity studies as-
1,2 and 3. Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents’ species rats and mice. - GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Species:
- other: 1.mouse 2.& 3. rats
- Strain:
- other: 1. Swiss 2.&3. Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1& 2
Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:20-22g
- Fasting period before study: No data available
- Housing: polycarbonate cages
- Diet (e.g. ad libitum): The animals were fed Gold Mohur Hind Lever diet ad libitum.
- Water (e.g. ad libitum): water ad libitum.
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24± 0.5°C
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): a 12 h dark and 12 h
light cycle. - Route of administration:
- oral: unspecified
- Vehicle:
- other: 1&2.de-ionized triple glass distilled water
- Details on oral exposure:
- 1&2.The test material were dissolved in de-ionized triple glass distilled water
- Doses:
- 1.2330mg/kg bw
2.2150 mg/kg bw
3. 2000mg/kg bw - No. of animals per sex per dose:
- 1 & 2 .
Total :10
0 mg/kg bw: 5
2330mg/kg bw:5 - Control animals:
- yes
- Details on study design:
- 1&2.The gross behavioural changes were recorded at 30, 60, 120 and 240 min using method of Irwin (1959).10 The changes in rectal temperature were recorded by using the thermocouple probes on Digital precision thermometer-DU-3S (ELLAB, DENMARK).
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - <= 2 330 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed in treated mouse at 2330mg/kg bw.
- Mortality:
- 1.& 2. 50% mortality was observed in treated mouse at 2330 and 2150mg/kg bw.
3. No mortality at 2000mg/kg bw was observed - Clinical signs:
- other: 1.& 2.Behavioral changes like somnolence (general depressed activity), convulsions or effect on seizure threshold were observed
- Gross pathology:
- no data available
- Other findings:
- no data available
- Interpretation of results:
- other: Not classified
- Conclusions:
- The test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic atleast in the dose range of 2000-2330 mg/kg bw.
- Executive summary:
- Data available for the similar read across
chemicals has been reviewed to determine the acute oral toxicity of the
test chemical manganese(2+) bis(phosphinate) (10043-84-2).The studies are
as mentioned below:
Study 1
In acute oral toxicity study, male Swiss strain Albino mice were treated with test material in dose concentration 2330mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice. Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.
Study 2
In acute oral toxicity study, male and female Wistar rats were treated with test material in dose concentration 2150mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of5 animals.50% mortality was observed in treated rats at 2150mg/kg bw. Behavioural changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated rats .Therefore, LD50 was considered to be 2150mg/kg bw. When rats were treated with test material orally.
Study 3
In acute oral toxicity study, female Wistar rats were treated with test material in dose concentration 2000mg/kg bw orally according to OECD Test Guideline (TG) 420.No mortality was observed in treated rats at 2000 mg/kg bw. Therefore, LD50 was considered to be >2000 mg/kg bw. When rats were treated with test material orally
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 330 mg/kg bw
- Quality of whole database:
- Data from Authoritative database
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Data available for the similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical manganese(2+) bis(phosphinate) (10043-84-2).The studies are as mentioned below:
Study 1
In acute oral toxicity study, male Swiss strain Albino mice were treated with test material in dose concentration 2330mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice. Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.
Study 2
In acute oral toxicity study, male and female Wistar rats were treated with test material in dose concentration 2150mg/kg bw orally. The test material was dissolved in de-ionized triple glass distilled water. Each group consisted of5 animals.50% mortality was observed in treated rats at 2150mg/kg bw. Behavioural changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated rats .Therefore, LD50 was considered to be 2150mg/kg bw. When rats were treated with test material orally.
Study 3
In acute oral toxicity study, female Wistar rats were treated with test material in dose concentration 2000mg/kg bw orally according to OECD Test Guideline (TG) 420.No mortality was observed in treated rats at 2000 mg/kg bw. Therefore, LD50 was considered to be >2000 mg/kg bw. When rats were treated with test material orally.
Thus, based on the above summarised studies, manganese(2+) bis(phosphinate) (10043-84-2) and it’s read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, manganese(2+) bis(phosphinate) (10043-84-2)cannot be classified for acute oral toxicity. Hence, based on the data available for the similar read across, test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic at least in the dose range of 2000-2330 mg/kg bw.
Justification for classification or non-classification
Thus, comparing this value with the criteria of CLP regulation, manganese(2+) bis(phosphinate) (10043-84-2)cannot be classified for acute oral toxicity. Hence, based on the data available for the similar read across, test chemical manganese(2+) bis(phosphinate) (10043-84-2) is not likely to be toxic at least in the dose range of 2000-2330 mg/kg bw.
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