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EC number: 231-493-2 | CAS number: 7585-39-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
.Beta.-Cyclodextrin is relatively harmless in case of oral, dermal and inhalative administration.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Results reported with some details lacking
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- other procedure
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- animals had a weight of 150 - 200 g
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- dosed as a suspension
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- dosed animals were observed for 24 hours
- Statistics:
- LD50 according to Litchfiled Wilcoxson
- Preliminary study:
- not applicable
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: no mortality observed
- Mortality:
- no mortality was observed
- Clinical signs:
- other: lower tonicity and hyperpnoea were observed within the first hour. The animals recovered after 24 h.
- Gross pathology:
- no signs observed
- Other findings:
- none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Beta-cyclodextrin is practically nontoxic if administered orally to rats.
- Executive summary:
Beta-Cyclodextrin was administered to groups of 10 male and female rats at a limit concentration of 5000 mg/kg bw. No mortality was observed within these groups. In the first hour lower tonicity and hyperpnoea were observed. All animals recovered after 24 h. No other signs of toxcicity were observed. The LD50 of beta-cyclodextrin was determined to be > 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study report with minor details (characterisation of test item) lacking
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- see principles
- Principles of method if other than guideline:
- Five young. adult, male and female albino rats (approximately 8 weeks of age) of the Sprague-Dawley derived strain were used in this study. The rats were chosen by ran-dom selection from the acclimated animals. Animals selected for the study weighed be-tween 206 and 217 grams. The animals were exposed to the test article for 4 hours. Six minutes were added to the 240 minute exposure period in order to allow the test system to reach 99 percent of the desired concentration (point of equilibration). Food and water were not made available during the exposure period. During the exposure period, the animals were individually housed in wire-mesh cages. Following exposure, the animals remained in the chamber for a minimum. of six minutes. The chamber was maintained during these six minutes at the designated airflow rate of 100 L/minute using clean am-bient air only.. After the exposure, animals were again individually housed. Animals were observed twice daily and body weights were recorded periodically throughout the 14-day study period. All animals were subjected to a gross necropsy and examined for lesions and/or abnormalities.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1. Species/Strain: Sprague-Dawley Rats
2. Source: Charles River Breeding Laboratories. Inc.
3. Age at Initiation: Young adult
4. Number/Sex: 5/sex.
5. Identification: Color coded cage tag.
6. Housing: Individually housed in stainless steel wire
mesh bottom cages.
8. Water: Tap water, ad libitum. except during the exposure period. Water is monitored for contaminants at periodic intervals according to the FDRL Standard Operating Pro-cedures
9: Environment: All animals will be housed in environment controlled rooms with tem-perature and relative humidity regulated as per “Guide for the Care and Use of Labora-tory Animals”. A 12-hour light-dark cycle will be maintained.
10. Quarantine: Minimum of 5 days. During this conditioning period, the rats will be ob-served for any clinical signs of disease. All rats with any evidence of disease or physical abnormalities will be discarded.
Animals selected for the study weighed between 206 and 217 grams. - Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The exposure was performed in a 128 L acrylic (plexiglass), portable chamber designed by the FDRL scientific staff. Total airflow through the chamber was maintained at a rate of 100 L/minute using a transvector jet and monitored using a pre-standardized pressure gauge attached to the transvector jet. The test atmosphere was vented via an air treatment system constructed of a glass fiber pre-filter, Micretain HEPA filter and an activated charcoal bank. The test article was delivered into the exposure chamber by means of a NBS-II dust generator using an air inlet port, which allows the test article and incoming air to mix evenly within the chamber at the top before being drawn down over the animals.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetry
- Duration of exposure:
- 4 h
- Remarks on duration:
- 6 additional minutes were chosen in order to allow the test system to reach 99 percent of the desired concentration (point of equilibration)
- Concentrations:
- Nominal Concentration: The nominal concentration of Beta Cyclodextrin was 15.4 mg/L, Which was calculated by dividing the total amount of test article utilized in milli-grams by the total volume of air in liter that passed through the chamber.
Actual Concentration: The actual chamber concentration of Beta Cyclodextrin was 4.9 mg/L of air which was determined by gravimetric analysis.
Chamber air was drawn through a pre-weighed glass fiber filter (Gelman Type A/E, 99.7% efficient at 0.3 µm) held in an open-faced holder. The change in weight of the filter was then determined (mg) and divided by the volume of chamber air sampled through the filter (L). Four samples per hour were taken and the average actual concen-tration calculated. - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Five young. adult, male and female albino rats (approximately 8 weeks of age) of the Sprague-Dawley derived strain were used in this study. The rats were chosen by ran-dom selection from the acclimated animals. Animals selected for the study weighed be-tween 206 and 217 grams. The animals were exposed to the test article for 4 hours. Six minutes were added to the 240 minute exposure period in order to allow the test system to reach 99 percent of the desired concentration (point of equilibration). Food and water were not made available during the exposure period. During the exposure period, the animals were individually housed in wire-mesh cages. Following exposure, the animals remained in the chamber for a minimum. of six minutes. The chamber was maintained during these six minutes at the designated airflow rate of 100 L/minute using clean am-bient air only. After the exposure, animals were again individually housed. Animals were observed twice daily and body weights were recorded periodically throughout the 14-day study period. All animals were subjected to a gross necropsy and examined for le-sions and/or abnormalities.
- Statistics:
- not reported
- Preliminary study:
- not applicable
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 4.9 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: no mortality observed at limit concentration
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.9 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: none
- Mortality:
- none obserbed
- Clinical signs:
- other: No mortality occurred. Nasal discharge was noted in all animals immediately following exposure. This effect generally cleared by day 2 of the study. .
- Body weight:
- Body weight data were just slightly affected. The test article exposure did not exhibit an adverse effect upon body weight gain in males. Weight loss was recorded in one female at days 8 and 15.
- Gross pathology:
- No lesions or abnormalities were noted during gross necropsy examination.
- Other findings:
- none observed
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substanec reveals a low degree of toxicity.
- Executive summary:
Five young. adult, male and female albino rats (approximately 8 weeks of age) of the Sprague-Dawley derived strain were used to evaluate the inahaltion toxicity of .beta.-cyclodextrin. The study was a limit whole body inhalation study at a nominal concentration of 15.4 mg/l and a gravimetrically measured concentration of 4.9 mg/l. It was performed to a guideline equivalent to OECD 403. The average actual concentration of Beta Cyclodextrin was 32% of the nominal concentration. Adsorption of the test article to chamber surfaces, dermal exposure to the animals and the generation of particle aggregates which do not remain suspended in the test atmosphere, contributed to this difference.. The animals were exposed to the test article for 4 hours. Six minutes were added to the 240 minute exposure period in order to allow the test system to reach 99 percent of the desired concentration (point of equilibration). Food and water were not made available during the exposure period. During the exposure period, the animals were individually housed in wire-mesh cages. Animals were observed twice daily and body weights were recorded periodically throughout the 14-day study period. All animals were subjected to a gross necropsy and examined for lesions and/or abnormalities. No mortality occurred. Nasal discharge was noted in all animals immediately following exposure. Body weight data were just slightly affected. The test article exposure did not exhibit an adverse effect upon body weight gain in males. Weight loss was recorded in one female at days 8 and 15. No lesions or abnormalities were noted during gross necropsy examination. Four-hour whole-body exposure to a dust generated from Beta Cyclodextrin at an average actual concentration of 4.9 mg/L failed to produce mortality in five male and five female Sprague-Dawley rats. The LC0 is >= 4.9 mg/l and it can be assumed that the LC50 is also > 5.0 mg/l due to lack of mortality and only slight signs of toxicity in this test.
Reference
Particle SizeAnalysis: Particle size analyseswereperformed once perhourusing a multijet cascade impactor (Model 02-200, In-ToxProductsAlbuquerque, NM). Stages one to seven of the impactorwerefittedwith preweighedstainless steel impaction substrates. Stage eight (final filter stage)wasfitted with a preweighed cellulose filter membrane (Gelman TypeA/Et47mm,Triacetate,99.7%efficient at 0.3µm).Chamber airwas drawn throughthe impactor at a rate of 20 L/minute and the change in weight of each collection substrate (including the filter) was subsequently determined. The mean cumulative percent of aerosol collected at each stage was determined and a lognormal distribution curve plotted. Themeanparticle size of the aerosolgenerated ,geometric standard deviation and percent of the sample (by weight) comprised of particles < 12µmin size were determined.
Chamber Specifications
Chamber volume (L): 128 L
Airflow exchange rate: 100 L/minute
Equilibrium time (99%): 6 minutes
Exposure duration at equilibrium: 240 minutes
Total exposure duration: 246 minutes '
Equilibrium/total exposure duration: 2%
Total volume of air: 24600 L
Test article utilized: 379.6 g
Mass median aerodynamic diameter (MMAD): 3.8 µm
Geometric standard deviation (ag): 2.2
Estimated percent of collected particles < 12 µm: 92%
Test Atmosphere Temperature and Relative Humidity:
Initial temperature (OC): 22
Final temperature (OC): 23
Average temperature (OC): 23
Range (QC): 22-23
Initial relative humidity (%): 41
Final relative humidity (%): 44
Average relative humidity (%): 43
Range (%): 40-46
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 000 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study report but substance identity (Copper compound used) could not be determined
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals used for this study were Sprague-Dawley rats lCO: OFA-SD (lOPS Caw) supplied by lffa Credo. 69210 L'Arbresle. France. Upon their arrival at the testing facility the animals were acclimatized to the experimental environment for at least 5 days dur-ing which they were observed daily.
On the first day of treatment, the adult animals were approximately 8 weeks old, and had a mean weight of 273 ± 7 g for the males and 228 ± 5 g for the females. They were individually identified by earmarks or earnotches.
Temperature: 22 ± 3°C
Hygrometry: 50 ± 20% relative humidity
Light/dark cycle: 12 hours of light/12 hours of dark
The air was non-recycled and filtered by absolute filters.
The animals were housed in groups of 4 to 7 animals of the same sex per cage during the acclimatization period and individually during the study. They were housed in steri1izable polycarbonate cages (48 x 27 x 20 cm) during the acclimatization period, and (35.5 x 23.5 x 19.3 cm) throughout the study. They were covered with a stainless steel lid containing food and a water bottle. Sifted and dusted sawdust was provided as litter (SICSA, 94142 Alfortville France). An analysis of the potential residues and major contaminants was performed periodically (Laboratoire Wolff, 92110 Clichy, France).
During the study, the animals were fed ad libitum with a certified pellet diet "Rats - Mice sustenance ref. A04 C" (U .A.R., 91360 Villemoisson-sur Orge, France). An analysis of the quality of the food and the major contaminants (pesticides, heavy metals, mycotox-ins, etc.) was performed by the supplier and given for each batch. During the study, the animals had free access to tap water filtered by a 0.22 micron filter membrane (Societe Millipore, 78140 Velizy, France) and contained in water bottles. Bacteriological and chemical analyses of the water and detection of the major contaminants (pesticides, heavy metals and nitrosamines) were made periodically (Laboratoire Municipal et Re-gional de Rouen, 76000 Rouen, France - Centre de Nutrition Humaine, 54000 Nancy, France - Laboratoire Departemental d 'Analyses , 27000 Evreux, France) . - Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The day before treatment. the dorsal area of each animal was clipped with an electric clipper on an area of 6 x 8 cm. Only animals with healthy
intact skin were used for the study. The skin was pre-moistened with 2 ml of water for injections and then applied to an area of skin representing approximately 10% (5 x 6 cm for the females and 5 x 7 cm for the males) of the body surface of the animal.
The test substance and the gauze patch were held in contact with the skin for 24 hours by means of an adhesive hypoallergic aerated semi-occlusive dressing (Laboratoires de Pansements et d'Hygiene. 21300 Chenove. France) attached to a restraining bandage (Laboratoires 3M Sante. 92245 Malakoff. France). This dressing prevented the ingestion of the test substance by the animal - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed frequently after application of the test substance and at least once
a day for 14 days in order to determine the reversibility or irreversibility of any clinical signs.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology. - Statistics:
- not reported
- Preliminary study:
- not applicable
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Remarks on result:
- other: none
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Remarks on result:
- other: none
- Mortality:
- No deaths occurred during the observation period.
- Clinical signs:
- other: No clinical signs were observed during the study.
- Gross pathology:
- The macroscopic examination of the main organs of the animals sacrificed
at the end of the study revealed no apparent abnormality.
Due to the absence of macroscopic lesions. no samples were taken for
histological examinations. - Other findings:
- none
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD0 of beta-Cyclodextrin administered to Sprague-Dawley rats was >= 2000 mg/kg bw under the conditions of the study.
- Executive summary:
Beta-Cyclodextrin (95% pure; 4.5% Copper) was evaluated in rats according to OECD Guideline No. 402. The test substance was prepared in its original form on a moistened compress at a dose of 2000 mg/kg and then applied to the skin of 10 Sprague-Dawley rats (5 males and 5 females). After 24 hours under a semi-occlusive dressing, residual test substance was removed using a compress saturated with water.
The mortality. general behaviour and body weight gain of the animals were observed for a period of 14 days after the single application of the test substance. A necropsy was performed on each animal sacrificed at the end of the study.
The general behaviour and body weight gain of the animals were not influenced by the treatment. No deaths occurred at the dose level of 2000 mg/kg. The macroscopic examination revealed no abnormalities in the animals sacrificed at the end of the study.
Under our experimental conditions, the LD 50 of the test substance beta-Cyclodextrin administered by dermal route in rats was higher than or equal to 2000 mg/kg.No signs of toxicity were observed at this dose level.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Beta-Cyclodextrin was administered to groups of 10 male and female rats at a limit concentration of 5000 mg/kg bw. No mortality was observed within these groups. In the first hour lower tonicity and hyperpnoea were observed. All animals recovered after 24 h. No other signs of toxcicity were observed. The LD50 of beta-cyclodextrin for rats of both sex was determined to be > 5000 mg/kg bw.
Beta-Cyclodextrin was administered to groups of 10 male and female mice at a limit concentration of 3000 mg/kg bw. No mortality was observed within these groups. In the first hour lower tonicity, somnolentia and hyperpnoea were observed. All animals recovered after 24 h. No other signs of toxcicity were observed. The LD50 of beta-cyclodextrin for mice of both sex was determined to be > 3000 mg/kg bw.
Beta cyclodextzrin (98% pure) was assessed for its dermal toxicity in 5 rats of each sex according to OECD Guideline 402. The test item was held in contact with the skin by a dressing throughout a 24-hour period. The dressing consisted of a gauze-dressing and non-irritating tape and was fixed with an additional dressing in a suitable manner. Under the conditions of the study, single dermal application of the test item to rats at a limit dose of 2000 mg/kg body weight was associated with mild signs of toxicity, but no mortality. Chromodacryorrhea was observed in 2 of 5 female animals and in 1 of 5 male animals. 1 of 5 female animals and 1 of 5 male animals showed a dark discolouration of the right lung. The body weight development of all male and female animals was within the expected range, except for a slight weight loss in 1 out of 5 female animals. Scratches were observed in 2 of 5 female. All signs of irritation were reversible within the observation period, except for 1 of 5 female animals. For acute percutaneous toxicity neither mortalities nor significant clinical signs of toxicity were observed at a dose of 2000mg/kg body weight.
Beta-Cyclodextrin was also evaluated in rats in another study according to OECD Guideline No. 402. The test substance was prepared in its original form on a moistened compress at a dose of 2000 mg/kg and then applied to the skin of 10 Sprague-Dawley rats (5 males and 5 females). After 24 hours under a semi-occlusive dressing, residual test substance was removed using a compress saturated with water.
The mortality. general behaviour and body weight gain of the animals were observed for a period of 14 days after the single application of the test substance. A necropsy was performed on each animal sacrificed at the end of the study.
The general behaviour and body weight gain of the animals were not influenced by the treatment. No deaths occurred at the dose level of 2000 mg/kg. The macroscopic examination revealed no abnormalities in the animals sacrificed at the end of the study.
Under our experimental conditions, the LD 50 of the test substance beta-Cyclodextrin administered by dermal route in rats was higher than or equal to2000 mg/kg.No signs of toxicity were observed at this dose level.
Five young. adult, male and female albino rats (approximately 8 weeks of age) of the Sprague-Dawley derived strain were used to evaluate the inahaltion toxicity of .beta.-cyclodextrin. The study was a limit whole body inhalation study at a nominal concentration of 15.4 mg/l and a gravimetrically measured concentration of 4.9 mg/l. It was performed to a guideline equivalent to OECD 403. The average actual concentration of Beta Cyclodextrin was 32% of the nominal concentration. Adsorption of the test article to chamber surfaces, dermal exposure to the animals and the generation of particle aggregates which do not remain suspended in the test atmosphere, contributed to this difference.. The animals were exposed to the test article for 4 hours. Six minutes were added to the 240 minute exposure period in order to allow the test system to reach 99 percent of the desired concentration (point of equilibration). Food and water were not made available during the exposure period. During the exposure period, the animals were individually housed in wire-mesh cages. Animals were observed twice daily and body weights were recorded periodically throughout the 14-day study period. All animals were subjected to a gross necropsy and examined for lesions and/or abnormalities. No mortality occurred. Nasal discharge was noted in all animals immediately following exposure. Body weight data were just slightly affected. The test article exposure did not exhibit an adverse effect upon body weight gain in males. Weight loss was recorded in one female at days 8 and 15. No lesions or abnormalities were noted during gross necropsy examination. Four-hour whole-body exposure to a dust generated from Beta Cyclodextrin at an average actual concentration of 4.9 mg/L failed to produce mortality in five male and five female Sprague-Dawley rats.
Justification for classification or non-classification
The LC50 under inhalative administration is > 4.9 mg/l and it can be assumed that the LD50 is also > 5.0 mg/l due to lack of mortality in this test. The LD50 of beta-cyclodextrin after oral administration for mice and rats was determined to be > 3000 mg/kg bw and > 5000 mg/kg bw respectively. The LD50 of beta-cyclodextrin after dermal administration for rats was determined to be > 2000 mg/kg bw.
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