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EC number: 228-207-3 | CAS number: 6168-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 September 2016 to 18 November 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- DL-2-aminopropan-1-ol
- EC Number:
- 228-207-3
- EC Name:
- DL-2-aminopropan-1-ol
- Cas Number:
- 6168-72-5
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 2-aminopropan-1-ol
1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Columbia Wastewater Treatment Plant
- Storage conditions: Effluent was aerated and stored at app. 20 Degree Celcius
- Pretreatment: Upon arrival in lab, ap. 1 lit of the secondary effluent that was collected was filtered through glass wool. The first 200mL of filtrate was discarded and remainder was aerated in a 20 degree Celcius environmental chamber until added to the test medium
- Water filtered: yes
- Type and size of filter used, if any: Glass wool - Duration of test (contact time):
- 29 d
Initial test substance concentration
- Initial conc.:
- 3 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The primary objective of this study was to evaluate the aerobic biodegradability of the test substance, RS-12401.00, in water containing mineral salts and the secondary effluent from a wastewater treatment plant (WWTP) as the source of microbial inoculum. The test substance was exposed to the effluent inoculum under aerobic conditions for 29 days at approximately 20°C. A reference substance treatment containing readily biodegradable sodium benzoate at a nominal concentration of 3 mg/L was concurrently tested to verify the viability of the microbial inoculum. A control treatment containing no lest or reference substance was concurrently tested to measure the oxygen uptake caused by endogenous microbial respiration. Two biochemical oxygen demand (BOD) bottles from each treatment were randomly removed after 0, 5, 15, 21, and 29 days of incubation at 20°C and were measured for dissolved oxygen concentration and for pH.
The effluent was obtained from the Columbia Wastewater Treatment Plant in Columbia, Missouri on 22 September 2016. The effluent was aerated and stored at approximately 20°C for 5 days.
Microbial enumeration was performed at Day 0 on the effluent and on one replicate for each treatment at the end of the test to further investigate microbial activity/viability during the testing. These analyses indicated that the microbial inoculum remained viable and active through the end of the test in each treatment.
Percent degradation was calculated by expressing BOD as a percent of theoretical oxygen demand
(ThOD). ThOD was 1.70 mg O2/mg assuming no nitrification, and 2.56 mg O2/mg assuming complete nitrification, calculated based on the elemental composition.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 62.8
- Sampling time:
- 29 d
- Remarks on result:
- other: Based on ThOD assuming complete nitrification
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 94.5
- Sampling time:
- 29 d
- Remarks on result:
- other: Based on ThOD assuming no nitrification
BOD5 / COD results
- Results with reference substance:
- Biodegradation of the reference substance reached 78.6% by Day 5. Based on these results, the reference substance met the acceptability criteria defined in the protocol (>60% degradation within 10 days) and confirmed that the microbial inoculum was viable and active.
Any other information on results incl. tables
10-day window:
Assuming biodegradation is linear between Day 5 and 21, the graph indicates that biodegradation reached> 10% after Day 6 and would have been >60% within a ten day window when no nitrification was assumed. The same conclusion cannot be inferred if complete nitrification was assumed, however the graph does indicate biodegradation would have been > 60% within a fourteen day window in this scenario. The application of a fourteen day window is considered acceptable by the guideline for closed bottle testing.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Oxygen consumed by the control did not exceed 1.5 mg O2/L. The oxygen levels remained at a measurable level in all treatments for the entire testing period. The reference substance met acceptability criteria.
- Interpretation of results:
- readily biodegradable
- Remarks:
- The test item is readily biodegradable under both scenarios, i.e. no nitrification and complete nitrification. It passes the 13-day window which applies to closed bottle testing.
- Executive summary:
The test substance DL-2-aminopropan-1-ol was readily biodegradable in OECD 301D protocol, based on 94.5% (assuming no nitrification) and 62.8% (assuming complete nitrification) degradation by Day 29.
The percent degradation for the reference substance reached 78.6% by Day 5, meeting the test acceptability criteria (>60% biodegradation within 10 days) and further supported the presence of a viable and active microbial population.
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