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Diss Factsheets
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EC number: 221-761-7 | CAS number: 3228-02-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- details on test conditions, test concentrations, reference substance, individual/summary results not reported however, it is stated that the studes were performed in conformtiy with the Guideline thus the quality criteria should have been met in this study. GLP status not reported and study performed after 2008 so not eligible as a valid test under REACH Regulation
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The three-brood reproduction test was conducted to evaluate the influence of the test item on the survival and reproduction of daphnids (Ceriodaphnia dubia).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-isopropyl-m-cresol
- EC Number:
- 221-761-7
- EC Name:
- 4-isopropyl-m-cresol
- Cas Number:
- 3228-02-2
- Molecular formula:
- C10H14O
- IUPAC Name:
- 4-isopropyl-m-cresol
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): p-thymol
- Source: Wako Pure Chemical Co. (Osaka, Japan)
- Analytical purity: 99%
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Water solubility: 860 mg/L
- log Kow:: 3.52
- pKa: 10.36 ± 0.18
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- TEST ORGANISM
- Source: National Institute for Environmental Studies (Tsukuba, Japan)
ACCLIMATION
- Acclimation period: Acclimated in the laboratory of the University of Tokushima at least for 3 months.
Study design
- Test type:
- semi-static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 8 d
- Post exposure observation period:
- None
Test conditions
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- TEST SYSTEM
- Ten replicates of Ceriodaphnia were placed in each snap cap of 30 ml size to prevent a shortage of dissolved oxygen.
- Renewal rate of test solution: The solutions were replaced every 48 h and the concentration before and after the replacement was analyzed using the HPLC.
EFFECT PARAMETERS MEASURED
The survival and the number of neonates was counted for eight days, when most of the Ceriodaphnia had finished delivering three broods. Only the numbers of first three broods were counted and compared with the blanks. - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 8 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.07 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: survival and the number of neonates was counted for 8 days
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 8-day NOEC was determined to be 1070 µg/L for the reproduction and for the survival of the adult test animals, respectively.
- Executive summary:
The three-brood reproduction test was conducted to evaluate the influence of the test item on the survival and reproduction of daphnids (Ceriodaphnia dubia).
Ten replicates of Ceriodaphnia were placed in each snap cap of 30 mL size to prevent a shortage of dissolved oxygen. Five concentrations and blanks were prepared with dechlorinated tap water, and the survival and the number of neonates was counted for eight days, when most of the Ceriodaphnia had finished delivering three broods. The solutions were replaced every 48 h (i.e. a semi-static system) and the concentration before and after the replacement was analyzed using the HPLC. Only the numbers of first three broods were counted and compared with the blanks. Multiple comparisons were conducted to determine NOEC values. The geometrical mean of the measured concentration of the selected antimicrobials was used for the determination of NOEC.
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