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EC number: 213-986-4 | CAS number: 1071-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No repeat-dose toxicity data are available for 3-(trichlorosilyl)propiononitrile, therefore good quality data for the related substance 3-(triethoxysilyl)propionitrile have been read-across.
In an oral OECD 422 study in which rats were dosed by gavage with 3-(triethoxysilyl)propiononitrile at doses up to 1000 mg/kg bw/day. Increased organ weights (kidneys, spleen, heart and liver in males; kidneys and spleen in toxicity group females), slight reduction in red cell count (not statistically significant), hemoglobin concentration and hematocrit in males and toxicity group females and histopathological changes in kidneys (chronic tubular lesions of minimal to moderate severity with hyperplasia of the renal pelvis epithelium and renal pyelonephritis) were noted in males and toxicity group females dosed at 1000 mg/kg bw/day. Administration of 500 mg/kg bw/day resulted in increased organ weights (kidneys, heart and liver in males only) and histopathological changes in kidneys including chronic tubular lesions, hyperplasia of the renal pelvis epithelium and renal pyelonephritis (males and toxicity group females) and spleen including extramedullary hematopoiesis (males only).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
Additional information
There are no repeated dose toxicity data on 3 -(trichlorosilyl)propionitrile or its hydrolysis product, 3 -propanenitrilesilanetriol, so good quality data for the related substance 3 -(triethoxysilyly)propionitrile has been used to assess the general systemic toxicity of
3 -(trichlorosilyl)propionitrile. Local effects from the other hydrolysis product (HCl) are no addressed by these data.
3 -(trichlorosilyl)propionitrile hydrolyses rapidly in contact with water (half-life <1 second at pH 7), generating HCl and 3 -propanenitrilesilanetriol. 3 -(Triethoxysilyl)propionitrile (CAS 919 -31 -3) hydrolyses more slowly at pH 7 (half-life ca. 7 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other ethoxysilanes. The relevant hydrolysis products are ethanol and 3 -propanenitrilesilanetriol. Both parent materials therefore generate a common silanol hydrolysis product. At the tested dose levels and exposure levels relevant for humans,
ethanol generated by hydrolysis in the stomach is not expected to contribute any repeated dose toxicity effects. It is therefore considered appropriate to read-across the results of the oral OECD 422 study on CAS 919 -31 -3.Justification for classification or non-classification
There are no data to suggest that 3 -(trichlorosilyl)propionitrile should be classified for specific target organ toxicity (repeated).
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