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Diss Factsheets
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EC number: 203-761-9 | CAS number: 110-38-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction (see : Any other information on materials and methods incl. tables)
- Principles of method if other than guideline:
- Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- other: calculation
- Water / sediment media type:
- natural water: freshwater
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: BCFBAF v3.01
- Result based on calculated log Pow of: 4.79 (estimated, KOWWIN v.1.68) - Type:
- BAF
- Value:
- 105.7 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Arnot Gobas (including biotransformation rate estimates, upper trophic)
- Key result
- Type:
- BCF
- Value:
- 105.7 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Arnot Gobas (including biotransformation rate estimates, upper trophic)
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction (see : Any other information on materials and methods incl. tables)
- Principles of method if other than guideline:
- Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- other: calculation
- Water / sediment media type:
- natural water: freshwater
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: BCFBAF v3.01
- Result based on calculated log Kow of: 4.79 (estimated, KOWWIN v.1.68) - Type:
- BCF
- Value:
- 28.52 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Regression based estimate
- Details on results:
- For detailed describtion on the model and its applicability, see "Any other information on materials and methods incl. tables".
Referenceopen allclose all
Estimated Log BCF (mid trophic) = 2.154 (BCF = 142.4 L/kg wet-wt)
Estimated Log BAF (mid trophic) = 2.158 (BAF = 143.9 L/kg wet-wt)
Estimated Log BCF (lower trophic) = 2.192 (BCF = 155.6 L/kg wet-wt)
Estimated Log BAF (lower trophic) = 2.230 (BAF = 169.7 L/kg wet-wt)
Arnot-Gobas BCF & BAF Methods (assuming a biotransformation rate of zero):
Estimated Log BCF (upper trophic) = 3.736 (BCF = 5443 L/kg wet-wt)
Estimated Log BAF (upper trophic) = 4.685 (BAF = 4.838e+004 L/kg wet-wt)
Biotransformation Rate Constant:
kM (Rate Constant): 2.735 /day (10 gram fish)
kM (Rate Constant): 1.538 /day (100 gram fish)
kM (Rate Constant): 0.865 /day (1 kg fish)
kM (Rate Constant): 0.4864 /day (10 kg fish)
Bio Half-Life Normalized to 10 g fish at 15 deg C: 0.2534 days
Description of key information
The BCF of Ethyl decanoate estimated with the BCFWin program is equal to 28.52 L/kg whole body w.w. (method based on log Kow). The Arnot-Gobas model gives a BCF and a BAF of 105.7 L /kg whole body w.w.
The highest BCF value of 105.7 L/kg whole body w.w. is considered as representative of the registered substance, Ethyl decanoate, which is not bioaaccumulable.
Key value for chemical safety assessment
- BCF (aquatic species):
- 105.7 L/kg ww
Additional information
No experimental study investigating the bioaccumulation of “Ethyl decanoate” is available. Using the BCFWinprogram, the BCF value of 28.52 L/kg was calculated for Ethyl decanoate using the regression method based on log Kow. Since this QSAR is validated and the substance fits in the applicability domain of the model, then the prediction is considered as reliable and Ethyl decanoate is not bioaccumulable.
Using the Arnot-Gobas program, which integrates the metabolic transformation in fish and the exposure through the water and the diet, BCF and BAF values are equal to 105.7 L/kg. This QSAR is also validated and the substance fits in its applicability domain. So the prediction is considered as reliable and confirms the lack of bioaccumulation potential of the substance Ethyl decanoate.
It can be assumed that the BCF of Ethyl decanoate is low and can be represented by the value ≤ 105.7 L/kg w.w.
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