Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 936-023-6 | CAS number: 950782-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 165-4 (Laboratory Studies of Pesticide Accumulation in Fish)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-6 (Aquatic Organism Accumulation Tests)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1730 (Fish Bioconcentration Test)
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- TEST ORGANISM
- Common name: Bluegill Sunfish
- Source: Osage Catfisheries, Inc. (Osage Beach, MO)
- Length at study initiation: 4.9 ± 0.2 cm (mean ± SD)
- Weight at study initiation: 1.6 ± 0.3 g (mean ± SD)
- Health status: Healthy (<3% mortality during the acclimation period; no mortalities during the 48 hours immediately prior to testing)
ACCLIMATION
- Acclimation period: > 14 days
- Acclimation conditions: Fish were acclimated in culture tanks to soft process water, test temperature (22 ± 2°C), and photoperiod (16 hours light/8 hours dark)
- Type of food: commercial fish diet
- Feeding frequency: daily - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 26 d
- Total depuration duration:
- 14 d
- Hardness:
- 48 - 50 mg mg/L CaCO3
- Test temperature:
- 22 ± 1°C
- pH:
- 7.6 - 8.1
- Dissolved oxygen:
- above 60% saturation at all times
- TOC:
- TOC values during the uptake phase of the study (days 0 to 26) ranged from 23.3 to 58.5 µg carbon/mL.
TOC values measured prior to test initiation and during the depuration period were <0.5 µg carbon/mL (method limit of quantitation). - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beakers
- Material, size, headspace, fill volume: glass aquaria [60 cm (L) x 56 cm (W) x 30 cm (H)] with a water volume of 80 liters
- Type of flow-through: continuously flow through via a stand pipe
- Renewal rate of test solution (flow rate): approximately 6 times in a 24-hour period.
- No. of organisms per vessel: 76 fish (bioconcentration portion) and 30 (for the biotransformation study)
- No. of vessels per concentration (replicates): 1
- No. of vessels per control / vehicle control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline (Dilution water (soft process water) used in the Bayer CropScience Ecotoxicology Laboratory consists of on-site spring water blended with reverse osmosis water designed to produce soft water (40 to 60 mg/L as CaCO3). Both water types are screened semiannually for contaminants (e.g., pesticides and heavy metals) by an indpendent laboratory.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16-hour light and 8-hour dark photoperiod and with a 30-min dawn/dusk transition period.
- Light intensity: 778 to 1006 lux (mean 885 lux) - Nominal and measured concentrations:
- Nominal concentration: 0.3 and 3.0 μg ai/L
- Type:
- BCF
- Value:
- 11 dimensionless
- Basis:
- whole body d.w.
- Remarks:
- normalized to 6% lipid content
- Calculation basis:
- steady state
- Remarks:
- normalized to 6% lipid content
- Type:
- BCF
- Value:
- 16 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
Reference
For the biotransformation portion of the study, one group with 30 fish was exposed to a nominal concentration of 3.0 µg [triazine-2,4-14C] AE 1170437/L dilution water (0.1 mL MeOH/L dilution water; Aquarium D).
The average steady-state bioconcentration factors (BCFss) were 25.0 (edible tissue) and 46.0 (whole fish) for Aquarium B (low dose) and of 26.7 (edible tissue) and 51.1 (whole fish) for Aquarium C (high dose).
The time to reach 95% of Steady State ranged from 2.6 days in the non-edible tissue samples from Aquarium B (low dose) to 3.4 days in the non-edible tissue samples from Aquarium C (high dose). The half-life for clearance (t(1/2)) ranged from 0.59 days in the
non-edible tissue samples from Aquarium B (low dose) to 0.78 days in the non-edible tissue samples from Aquarium C (high dose). After 14 days in uncontaminated water, greater than 98% of the mean plateau radioactivity depurated from whole fish at both the low and high test levels.
The uptake rate constants (ku) were 24.1, 96.8, and 49.7 day-1 for the edible tissue, non-edible tissue, and whole fish samples from Aquarium B (low dose) and 28.6, 85.4, and 51.4 day-1 for the edible tissue, non-edible tissue, and whole fish samples from Aquarium C (high dose). The depuration rate constants (kd) were 0.939, 1.17, and 1.03 day-1 for the edible tissue, non-edible tissue, and whole fish samples from Aquarium B (low dose) and 1.01, 0.888, and 0.932 day-1 for the edible tissue, non-edible tissue, and whole fish samples from Aquarium C (high dose).
The kinetic bioconcentration factors (BCFk) were 25.6 and 28.4 in the edible tissue from Aquaria B and C, respectively, 82.5 and 96.2 in the non-edible tissue from Aquaria B and C, respectively, and 48.4 and 55.1 in the whole fish from Aquaria B and C, respectively. The major residue in all fish tissues was parent AE 1170437 (average of 34.5% and 29.5% of the TRR in the edible and non-edible tissue, respectively). The average percent lipid in all whole fish samples from Aquaria A, B, and C at all collection time points was 9.14%.
The steady-state BCF for parent AE 1170437 based on whole fish (wet weight) is 16, and the steady-state BCF for parent AE 1170437 normalized to 6% lipid content is 11.
Description of key information
The substance has no potential to bioaccumulate in aquatic organisms.
Key value for chemical safety assessment
- BCF (aquatic species):
- 11 dimensionless
Additional information
A study was conducted to determine the bioconcentration potential of the test substance from the aqueous environment into bluegill sunfish(Lepomis macrochirus) using a flow-through exposure system. The bioconcentration of the substance in bluegill sunfish was determined in a 40-day continuous flow-through study, which included a 26-day uptake period and a 14-day depuration period according to OECD 305.
The average steady-state bioconcentration factors (BCFss) were 25.0 (edible tissue) and 46.0 (whole fish) for the low dose(0.3 µg/L) and of 26.7 (edible tissue) and 51.1 (whole fish) for the high dose (3.0 µg/L). The time to reach 95% of Steady State ranged from 2.6 days in the non-edible tissue samples from Aquarium B (low dose) to 3.4 days in the non-edible tissue samples from Aquarium C (high dose). The half-life for clearance (t(1/2)) ranged from 0.59 days in the non-edible tissue samples from Aquarium B (low dose) to 0.78 days in the non-edible tissue samples from Aquarium C (high dose). After 14 days in uncontaminated water, greater than 98% of the mean plateau radioactivity depurated from whole fish at both the low and high test levels.
The steady-state BCF for the substance based on whole fish (wet weight) is 16, and the steady-state BCF for the substance normalized to 6% lipid content is 11.
Therefore, there are no indications for a bioaccumulation potential of the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.